Art

J-GLOBAL ID：201202213946119270   Reference number：12A1549802

Simultaneous enantiomeric determination of MDMA and its phase I and phase II metabolites in urine by liquid chromatography-tandem mass spectrometry with chiral derivatization

尿中のMDMAとそのフェーズIとIIの代謝物のエナンチオマーの同時定量

Author (10)： NAKANISHI Keiko (Osaka Prefectural Police Headquarters, Forensic Sci. Lab., 1-3-18 Hommachi, 541-0053, Chuo-ku, Osaka, JPN) ,  KATAGI Munehiro (Osaka Prefectural Police Headquarters, Forensic Sci. Lab., 1-3-18 Hommachi, 541-0053, Chuo-ku, Osaka, JPN) ,  ZAITSU Kei (Osaka Prefectural Police Headquarters, Forensic Sci. Lab., 1-3-18 Hommachi, 541-0053, Chuo-ku, Osaka, JPN) ,  SHIMA Noriaki (Osaka Prefectural Police Headquarters, Forensic Sci. Lab., 1-3-18 Hommachi, 541-0053, Chuo-ku, Osaka, JPN) ,  KAMATA Hiroe (Osaka Prefectural Police Headquarters, Forensic Sci. Lab., 1-3-18 Hommachi, 541-0053, Chuo-ku, Osaka, JPN) ,  MIKI Akihiro (Osaka Prefectural Police Headquarters, Forensic Sci. Lab., 1-3-18 Hommachi, 541-0053, Chuo-ku, Osaka, JPN) ,  KATO Hajime (Tohoku Pharmaceutical Univ., 4-4-1 Komatsushima, 981-8558, Aoba-ku, Sendai, JPN) ,  HARADA Ken-Ichi (Meijo Univ., Graduate School of Environmental and Human Sci. and Fac. of Pharmacy, 150 Yagotoyama, 468-8503, Tempaku ...) ,  TSUCHIHASHI Hitoshi (Osaka Medical Coll., Dep. of Legal Medicine, 2-7 Daigaku-cho, 569-8686, Takatsuki, Osaka, JPN) ,  SUZUKI Koichi (Osaka Medical Coll., Dep. of Legal Medicine, 2-7 Daigaku-cho, 569-8686, Takatsuki, Osaka, JPN)
Material： Analytical & Bioanalytical Chemistry  (Anal Bioanal Chem)
Volume： 404  Issue： 8  Page： 2427-2435  Publication year： Nov. 2012 
JST Material Number： E0425B  ISSN： 1618-2642  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Thesaurus term： *Urine ,  phase 1 study ,  phase 2 study ,  *metabolite ,  *enantiomer ,  *simultaneous determination ,  drug ,  derivatization ,  LC-MS analysis ,  Electrospray Ionization Mass Spectrometry ,  Tandem Mass Spectrometry ,  diastereomer ,  selected ion monitoring ,  glucuronic acid conjugation ,  sulfate conjugation ,  GC-MS analysis ,  oxygen heterocyclic compound ,  polynuclear aromatic compound ,  secondary amine ,  multiple-reaction monitoring ,  LC/ESI-MS/MS ,  *excreta ,  *excretory substance
Semi thesaurus term： Designer Drug ,  LC-ESI-MS/MS analysis

JST classification (2)： Miscellaneous analytical methods of organic compounds  (CC08034J) ,  Analysis of drugs  (GV01040Q)

Substance index (1)： MDMA

Reference (20)：

• United Nations Office on Drugs and Crime (UNODC), World drug report 2011
• Substance Abuse and Mental Health Services Administration (2011) The DAWN report, 24 March 2011
• Nakanishi K, Miki A, Zaitsu K, Kamata H, Shima N, Kamata T, Katagi M, Tatsuno M, Tsuchihashi H, Suzuki K (2012) Cross-reactivities of various phenethylamine-type designer drugs to immunoassays for amphetamines, with special attention to the evaluation of the one-step urine drug test Instant-View™, and the Emit® assays for use in drug enforcement. Forensic Sci Int 217:174-181
• Lim HK, Foltz RL (1989) Identification of metabolites of 3,4-(methylenedioxy)methamphetamine in human urine. Chem Res Toxicol 2:142-143
• de la Torre R, Farré M, Roset PN, Pizarro N, Abanades S, Segura M, Segra J, Camí J (2004) Human pharmacology of MDMA: pharmacokinetics, metabolism, and disposition. Ther Drug Monit 26(2):137-144

Terms in the title (6)： 尿 ,  MDMA ,  フェーズ ,  代謝物 ,  エナンチオマー ,  同時定量