Art

J-GLOBAL ID：201202252014154384   Reference number：12A1338245

Intravitreal injection or topical eye-drop application of a μ-calpain C2L domain peptide protects against photoreceptor cell death in Royal College of Surgeons’ rats, a model of retinitis pigmentosa

μ-カルパインC2Lドメインペプチドの硝子体内注射あるいは局所点眼適用は,網膜色素変性症のモデル,Royal College of Surgeonラットにおいて光受容体細胞死から保護する

Author (10)： OZAKI Taku (Dep. of Biochemistry and Molecular Biology, Fac. of Agriculture and Life Sci., Hirosaki Univ., Hirosaki, JPN) ,  OZAKI Taku (Dep. of Ophthalmology, Hirosaki Univ. Graduate School of Medicine, Hirosaki, JPN) ,  NAKAZAWA Mitsuru (Dep. of Ophthalmology, Hirosaki Univ. Graduate School of Medicine, Hirosaki, JPN) ,  YAMASHITA Tetsuro (Dep. of Biological Chemistry, Fac. of Agriculture, Iwate Univ., Morioka, JPN) ,  SORIMACHI Hiroyuki (Calpain Project, Tokyo Metropolitan Inst. of Medical Sci., Tokyo, JPN) ,  HATA Shoji (Calpain Project, Tokyo Metropolitan Inst. of Medical Sci., Tokyo, JPN) ,  TOMITA Hiroshi (Tohoku Univ., Inst. for International Advanced Interdisciplinary Res., Sendai, JPN) ,  ISAGO Hitomi (Tohoku Univ., Inst. for International Advanced Interdisciplinary Res., Sendai, JPN) ,  BABA Ayaka (Dep. of Biochemistry and Molecular Biology, Fac. of Agriculture and Life Sci., Hirosaki Univ., Hirosaki, JPN) ,  ISHIGURO Sei-ichi (Dep. of Biochemistry and Molecular Biology, Fac. of Agriculture and Life Sci., Hirosaki Univ., Hirosaki, JPN)
Material： Biochimica et Biophysica Acta  (BBA. Biomembranes)
Volume： 1822  Issue： 11  Page： 1783-1795  Publication year： Nov. 2012 
JST Material Number： B0207A  ISSN： 0005-2728  CODEN： BBBMBS  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： *Calpain ,  *peptide ,  *enzyme inhibitor ,  viral protein ,  HIV1 ,  fusion protein ,  *Retinitis Pigmentosa ,  *photoreceptor ,  Apoptosis ,  Mitochondria ,  NAD(P)H oxidoreductase ,  flavoprotein ,  *mu-calpain ,  Gene Products, tat ,  Apoptosis Inducing Factor ,  microorganism ,  animal virus
Semi thesaurus term： Tat protein ,  Mitochondrial Apoptosis-Inducing Factor

JST classification (2)： Biological function  (EB03040U) ,  Basic ophthalmology  (GP01020C)

Terms in the title (10)： μ-カルパイン ,  ドメイン ,  ペプチド ,  硝子体内注射 ,  点眼 ,  網膜色素変性症 ,  モデル ,  ラット ,  光受容体 ,  細胞死