Art

J-GLOBAL ID：201202273206312908   Reference number：12A0361549

Structural insights into the substrate specificity of bacterial copper amine oxidase obtained by using irreversible inhibitors

不可逆阻害剤を使って得られた細菌銅アミンオキシダーゼの基質特異性に関する構造的洞察

Author (8)： MURAKAWA Takeshi (Osaka Medical Coll., Osaka) ,  HAYASHI Hideyuki (Osaka Medical Coll., Osaka) ,  TAKI Masayasu (Kyoto Univ., Kyoto) ,  YAMAMOTO Yukio (Kyoto Univ., Kyoto) ,  KAWANO Yoshiaki (RIKEN Harima Inst./SPring-8, Hyogo) ,  TANIZAWA Katsuyuki (Osaka Univ., Osaka, JPN) ,  OKAJIMA Toshihide (Osaka Medical Coll., Osaka) ,  OKAJIMA Toshihide (Osaka Univ., Osaka, JPN)
Material： Journal of Biochemistry  (JB)
Volume： 151  Issue： 2  Page： 167-178  Publication year： Feb. 2012 
JST Material Number： W1920A  ISSN： 0021-924X  CODEN： JOBIAO  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： *diamine oxidase ,...
Semi thesaurus term： Arthrobacter ,...

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JST classification (2)： Enzyme in general  (EB09010D) ,  Microorganism biochemistry  (EG03020N)

Substance index (7)： (4-Hydroxybenzyl)hydrazine ,  Tyramine ,  Topaquinone ,  N-Ethylaniline ,  Phenylhydrazine ,  Benzylamine ,  Benzylhydrazine

Reference (45)：

• KNOWLES, P. F. Amine oxidases. Metal Ions in Biological Systems. 1994, 30, 361-403
• FLORIS, G. ed. Copper Amine Oxidases. Structures, Catalytic Mechanisms, and Role in Pathophysiology. 2009
• MATSUZAKI, R. Generation of the topa quinone cofactor in bacterial monoamine oxidase by cupric ion-dependent autooxidation of a specific tyrosyl residue. FEBS Lett. 1994, 351, 360-364
• CAI, D. Evidence of a self-catalytic mechanism of 2,4,5-trihydroxyphenylalanine quinone biogenesis in yeast copper amine oxidase. J. Biol. Chem. 1994, 269, 32039-32042
• CHOI, Y. H. Copper/topa quinone-containing histamine oxidase from Arthrobacter globiformis. Molecular cloning and sequencing, overproduction of precursor enzyme, and generation of topa quinone cofactor. J. Biol. Chem. 1995, 270, 4712-4720

Terms in the title (6)： 不可逆 ,  阻害剤 ,  細菌 ,  銅アミンオキシダーゼ ,  基質特異性 ,  洞察