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J-GLOBAL ID：201301014997010860 Update date: Mar. 12, 2025

Murata Yui

ムラタユイ | Murata Yui

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Affiliation and department：
Job title： JSPS Research Fellowship for Young Scientist

Research field (2)： Neuroscience - general , Psychiatry

Research keywords (10)：自閉症スペクトラム障害 , 神経発達障害 , レトロトランスポゾン , LINE-1 , 包括脳ネットワーク , Bipolar disorder , Schizophrenia , Psychiatric disorders , DNA methylation , Epigenetics

Research theme for competitive and other funds (5)：

2020 - 2024 Investigation of molecular mechanisms of LINE-1 regulation related to psychiatric disorders using animal models
2019 - 2021 動物モデルを用いた精神疾患様行動に関与するLINE-1制御分子機構の解明
2019 - 胎生期LINE-1活性異常に着目した精神神経疾患の病理学的分子基盤の解明
2015 - 2017 神経発達障害モデルマウスを用いた統合失調症様行動におけるLINE-1の関与
2017 - 統合失調症マウスモデルにおけるトランスポゾン転移機構の解析

Papers (21)：

Jianbin Du, Yutaka Nakachi, Yui Murata, Emi Kiyota, Tadafumi Kato, Miki Bundo, Kazuya Iwamoto. Exploration of cell type-specific somatic mutations in schizophrenia and the impact of maternal immune activation on the somatic mutation profile in the brain. Psychiatry and Clinical Neurosciences. 2024
Shinya Fujii, Yui Murata, Yuko Imamura, Yutaka Nakachi, Miki Bundo, Mie Kubota-Sakashita, Tadafumi Kato, Kazuya Iwamoto. Sex-dependent behavioral alterations in a poly(I:C)-induced maternal immune activation mouse model without segment filamentous bacteria. Neuroscience Letters. 2023. 137467-137467
Tempei Ikegame T, Yosuke Hidaka, Yutaka Nakachi, Yui Murata, Risa Watanabe, Hiroko Sugawara, Tatsuro Asai, Emi Kiyota, Takeo Saito, Masashi Ikeda, et al. Identification and functional characterization of the extremely long allele of the serotonin transporter-linked polymorphic region. Translational Psychiatry. 2021. 11. 119. 119-119
Yutaro Kobayashi, Yuriko Iwakura, Hisaaki Namba, Yui Murata, Kazuya Iwamoto, Hiroyuki Nawa. Inter-breeder differences in prepulse inhibition deficits of C57BL/6J mice in a maternal infection model for schizophrenia. Neuropsychopharmacology Reports. 2021
Ryota Kuroki, Yui Murata, Satoshi Fuke, Yutaka Nakachi, Jun Nakashima, Gregory C. Kujoth, Tomas A. Prolla, Miki Bundo, Tadafumi Kato, Kazuya Iwamoto. Establishment of qPCR assays for active LINE-1 subfamilies in mice and applications to the analysis of aging-associated retrotransposition. Frontiers in Genetics. 2020. 11. 519206

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MISC (39)：

村田唯, 岩本和也. 死後脳試料を用いた双極性障害のエピジェネティクス研究. 精神科. 2022. 40. 4
村田唯, 岩本和也. 精神疾患におけるゲノムデータベース. 疾患原因遺伝子・タンパク質の解析技術と創薬/診断技術への応用. 2022. 5. 2
柳田悠太朗, 仲地ゆたか, 吉川慧, 清田恵美, 渡邊理紗, 村田唯, 菅原裕子, 菅原裕子, 石川智久, 橋本衛, et al. セロトニントランスポーター遺伝子活性と高齢者における認知機能・うつ傾向の関連. 日本神経化学会大会抄録集(Web). 2022. 65th
村田唯, 藤飯慎也, 岩本和也. 【精神疾患と早期ライフステージイベントの関連】母体免疫活性化動物モデルにおける脳神経系LINE-1動態の解析. 日本生物学的精神医学会誌. 2021. 32. 3. 141-143
村田唯, 岩本和也. 【ストレスと神経系】ストレスの神経機構(動物実験を中心に) ストレスのエピゲノム研究. Clinical Neuroscience. 2021. 39. 6. 373-379

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Books (3)：

精神疾患におけるゲノムデータベース
技術情報協会 2022 ISBN:9784861048777
統合失調症におけるエピゲノム異常~患者由来脳組織および末梢組織を用いた最新研究
羊土社 2016 ISBN:9784758103558
第3部第7章「精神疾患」
羊土社 2013 ISBN:9784758120463

Lectures and oral presentations (27)：

Sex dependent abnormal behavior in polyI:C-induced maternal immune activation model without gut segmented filamentous bacteria in mice
(The 33rd CINP Hybrid World Congress of Neuropsychopharmacology 2022)
Serotonin transporter promoter activity regulated by polymorphisms and DNA methylation affects depression and cognitive decline in old people: The Arao study
(The 33rd CINP Hybrid World Congress of Neuropsychopharmacology 2022)
Gene activity of;serotoni;ssociates with cognitive function;depressive tendency;hippocampal volume in;older people
(Neuro2022(第45回日本神経科学大会・第65回日本神経化学会大会・第32回日本神経回路学会大会) 2022)
レトロトランスポゾンLINE-1転移モニターマウスの作製
(第44回日本分子生物学会 2021)
精神疾患の病態生理におけるトランスポゾンの役割
(第45回日本女性栄養・代謝学会学術集会/第10回日本DOHaD学会学術集会 2021)

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Education (4)：

2013 - 2017 The University of Tokyo Graduate School of Medicine Department of Molecular Psychiatry
2011 - 2013 Tsukuba University Graduate School of Comprehensive Human Sciences MS (Behavioral Sciences)
2010 - 2011 Tsukuba University Graduate School of Comprehensive Human Sciences Internship student
2007 - 2010 The University of Sydney Faculty of Sciencce Bachelor of Medical Science (First Class Honours)

Professional career (1)：

Doctor of Philosophy (Medicine) (The University of Tokyo)

Work history (2)：

2023/04 - 現在 RIKEN Center for Brain Science JSPS Research Fellowship for Young Scientist
2020/04 - 2023/04 Kumamoto University Department of Molecular Brain Science, Graduate School of Medical Sciences JSPS Research Fellowship for Young Scientist

Awards (11)：

2019/09 - 新学術領域「マルチケール病態脳」第2回領域会議ポスター賞
2018/09 - 第7回若手研究者育成プログラム奨励賞
2017/11 - 熊本大学肥後医育振興会学術奨励賞
2016/09 - 日本生物学的精神医学会合同年会優秀発表賞
2016/07 - 日本神経精神薬理学会 JSNP2016 Excellent Presentation Award

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Association Membership(s) (4)：

日本エピジェネティクス研究会 , THE JAPANESE SOCIETY OF NEUROPSYCHOPHARMACOLOGY , JAPANESE SOCIETY OF BIOLOGICAL PSYCHIATRY , THE JAPAN NEUROSCIENCE SOCIETY

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