Rchr
J-GLOBAL ID:201301019530967062   Update date: Jan. 31, 2024

Kiyoshi Nagata

ナガタ キヨシ | Kiyoshi Nagata
Homepage URL  (1): http://kaken.nii.ac.jp/d/r/80189133.ja.html
Research field  (3): Clinical pharmacy ,  Pharmacology ,  Pharmaceuticals - health and biochemistry
Research keywords  (30): チトクロームP450 ,  PXR ,  酵素誘導 ,  CYP3A4 ,  Induction ,  スルホトランスフェラーゼ ,  in vivo ,  CYP3A1 ,  発現抑制 ,  RNAi ,  マウス ,  レポーター ,  HNF-4 ,  アンチセンスRNA ,  P450 ,  nuclear receptor ,  肝特異的発現 ,  エンハンサー ,  シス-エレメント ,  転写因子 ,  Adenovirus ,  脳特異的発現 ,  sis-element ,  cis-element ,  抑制的な調節 ,  アデノウイルスベクター ,  MRP3 ,  核内レセプター ,  テストステロン6β-水酸化 ,  rat
Research theme for competitive and other funds  (25):
  • 2017 - 2020 Development of evaluation methods for drug-induced liver injury based on both chemical structure/biological reactivity of drugs and individual factors
  • 2014 - 2017 Differentiation of human iPS cells into hepatocytes and enterocytes: Development of first pass effect assessment model
  • 2013 - 2017 Development of a model for the monitoring ontogenic expression of CYP3A by used of secreted reporter-expressing iPS cells
  • 2009 - 2011 A new study of enzyme induction involved in pharmacokinetic : Identification of molecular mechanism for a novel enzyme induction
  • 2005 - 2006 Novel protective mechanisms for cholestatic hepatotoxicity-application to drug improving hepatic function
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Papers (69):
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MISC (59):
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Work history (1):
  • 2009 - 2011 東北薬科大学 薬学部 教授
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