Rchr
J-GLOBAL ID:201301019530967062   Update date: Dec. 10, 2020

Kiyoshi Nagata

ナガタ キヨシ | Kiyoshi Nagata
Homepage URL  (1): http://kaken.nii.ac.jp/d/r/80189133.ja.html
Research field  (3): Clinical pharmacy ,  Pharmacology ,  Pharmaceuticals - health and biochemistry
Research keywords  (30): チトクロームP450 ,  PXR ,  酵素誘導 ,  CYP3A4 ,  Induction ,  スルホトランスフェラーゼ ,  in vivo ,  CYP3A1 ,  発現抑制 ,  RNAi ,  マウス ,  レポーター ,  HNF-4 ,  アンチセンスRNA ,  P450 ,  nuclear receptor ,  肝特異的発現 ,  エンハンサー ,  シス-エレメント ,  転写因子 ,  Adenovirus ,  脳特異的発現 ,  sis-element ,  cis-element ,  抑制的な調節 ,  アデノウイルスベクター ,  MRP3 ,  核内レセプター ,  テストステロン6β-水酸化 ,  rat
Papers (43):
  • Yasushi Yamazoe, Takashi Yamada, Kiyoshi Nagata. Prediction and Characterization of CYP3A4-mediated Metabolisms of Azole Fungicides: an Application of the Fused-grid Template* system. Food safety (Tokyo, Japan). 2020. 8. 2. 34-51
  • Yuu Miyauchi, Yoshitaka Tanaka, Kiyoshi Nagata, Yasushi Yamazoe, Peter I Mackenzie, Hideyuki Yamada, Yuji Ishii. UDP-Glucuronosyltransferase (UGT)-mediated attenuations of cytochrome P450 3A4 activity: UGT isoform-dependent mechanism of suppression. British journal of pharmacology. 2020. 177. 5. 1077-1089
  • Takamitsu Sasaki, Keita Inami, Yoshihiro Numata, Kodai Funakoshi, Midori Yoshida, Takeshi Kumagai, Shuichi Kanno, Satomi Matsui, Takayoshi Toriyabe, Yasushi Yamazoe, et al. Activation of p38 Mitogen-Activated Protein Kinase by Clotrimazole Induces Multidrug Resistance-Associated Protein 3 Activation through a Novel Transcriptional Element. The Journal of pharmacology and experimental therapeutics. 2016. 359. 1. 102-9
  • Takeshi Kumagai, Yusuke Aratsu, Ryosuke Sugawara, Takamitsu Sasaki, Shinichi Miyairi, Kiyoshi Nagata. Indirubin, a component of Ban-Lan-Gen, activates CYP3A4 gene transcription through the human pregnane X receptor. Drug metabolism and pharmacokinetics. 2016. 31. 2. 139-45
  • Tatsuro Nakamura, Naho Yamaguchi, Yuu Miyauchi, Tomoki Takeda, Yasushi Yamazoe, Kiyoshi Nagata, Peter I Mackenzie, Hideyuki Yamada, Yuji Ishii. Introduction of an N-Glycosylation Site into UDP-Glucuronosyltransferase 2B3 Alters Its Sensitivity to Cytochrome P450 3A1-Dependent Modulation. Frontiers in pharmacology. 2016. 7. 427-427
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MISC (27):
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Work history (1):
  • 2009 - 2011 東北薬科大学 薬学部 教授
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