Watanabe Seiji

ワタナベセイジ | Watanabe Seiji

Affiliation and department：
Job title： Lecturer
Homepage URL (2)： http://www.riem.nagoya-u.ac.jp/4/mnd/index.html , http://www.riem.nagoya-u.ac.jp/4/mnd/index_en.html

Research field (3)： Neuropathology , Functional biochemistry , Pathobiochemistry

Research keywords (8)： Neurodegenerative diseases , Mitochondria-associated membranes (MAM) , Mouse models , Protein aggregation , Protein engineering , Amyotrophic lateral sclerosis (ALS) / Frontotemporal lobar degeneration (FTLD) , TAR DNA-binding protein 43 (TDP-43) , Cu/Zn superoxide dismutase (SOD1)

Research theme for competitive and other funds (12)：

2023 - 2026 TDP-43単量体の細胞質における凝集機序の解明
2019 - 2024 タンパク質の構造生物学に基づいた筋萎縮性側索硬化症の分子病態解明と治療法開発
2022 - 2023 Development of a novel mouse model recapitulates ALS pathology on oligodendrocytes
2020 - 2022 Analysis of a novel mechanism for maintenance of mitochondria-endoplasmic reticulum contact
2017 - 2021 Grant #17H04986

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Papers (37)：

Horiuchi M, Watanabe S, Komine O, Takahashi E, Kaneko K, Itohara S, Shimada M, Ogi T, Koji Yamanaka. ALS-linked mutant TDP-43 in oligodendrocytes induces oligodendrocyte damage and exacerbates motor dysfunction in mice. Acta neuropathologica communications. 2024. 12. 184
Akira Sobue, Okiru Komine, Fumito Endo, Chihiro Kakimi, Yuka Miyoshi, Noe Kawade, Seiji Watanabe, Yuko Saito, Shigeo Murayama, Takaomi C. Saido, et al. Microglial cannabinoid receptor type II stimulation improves cognitive impairment and neuroinflammation in Alzheimer’s disease mice by controlling astrocyte activation. Cell Death & Disease. 2024. 15. 858
Seiji Watanabe, Kangsa Amporndanai, Raheela Awais, Caroline Latham, Muhammad Awais, Paul M. O’Neill, Koji Yamanaka, S. Samar Hasnain. Ebselen analogues delay disease onset and its course in fALS by on-target SOD-1 engagement. Scientific Reports. 2024. 14. 1
Ting Wang, Akira Sobue, Seiji Watanabe, Okiru Komine, Takaomi C Saido, Takashi Saito, Koji Yamanaka. Dimethyl fumarate improves cognitive impairment and neuroinflammation in mice with Alzheimer's disease. Journal of neuroinflammation. 2024. 21. 1. 55-55
Okiru Komine, Syuhei Ohnuma, Kunihiko Hinohara, Yuichiro Hara, Mayuko Shimada, Tomohiro Akashi, Seiji Watanabe, Akira Sobue, Noe Kawade, Tomoo Ogi, et al. Genetic background variation impacts microglial heterogeneity and disease progression in amyotrophic lateral sclerosis model mice. iScience. 2024. 27. 2. 108872-108872

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MISC (10)：

渡邊征爾, 酒井昭平, 山中宏二. ER-ミトコンドリアコンタクトサイトの定量と観察(第6章-2). 実験医学別冊「疾患研究につながるオルガネラ実験必携プロトコール」. 2024
渡邊征爾, 山中宏二. 筋萎縮性側索硬化症におけるMAMの破綻. 実験医学(増刊). 2019. 37. 12. 138-144
渡邊征爾, 山中宏二. 第7回筋萎縮性側索硬化症(ALS). 和光純薬時報. 2018. 86. 4. 18-20
Watanabe S, Ilieva H, Tamada H, Nomura H, Komine O, Endo F, Jin S, Mancias P, Kiyama H, Yamanaka K. Collapse of mitochondria-associated membrane as common pathomechanism for amyotrophic lateral sclerosis. JOURNAL OF THE NEUROLOGICAL SCIENCES. 2017. 381. 104-104
Nishino K, Watanabe S, Komine O, Yamanaka K. Mice heterozygously lacking C-terminal domain of TDP-43 show age-dependent motor dysfunction. Journal of the Neurological Sciences. 2017. 381. 570

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Lectures and oral presentations (10)：

Monomerization of TDP-43 is akey determinant for inducing TDP-43 pathology in amyotrophic lateral sclerosis.
(Japan-UK Neuroscience Symposium 2023)
A novel role of the mitochondria-associated membrane against proteostatic stress
(The 66th Annual Meeting of the Japanese Society for Neurochemistry 2023)
TANK-binding kinase 1 (TBK1) induces cellular proteostatic stress response at the mitochondria-associated membrane
(The 95th Annual Meeting of the Japanese Biochemical Society 2022)
アグリソーム形成と液-液相分離は独立してTDP-43凝集体の形成を引き起こす
(第62回日本神経学会シンポジウム 2021)
Disruption of the mitochondria-associated membranes in motor neuronal degeneration
(The 93rd Annual Meeting of the Japanese Biochemical Society 2020)

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Education (2)：

2007 - 2012 The University of Tokyo Graduate School of Arts and Sciences Department of Life Sciences
- 2007 The University of Tokyo Faculty of Arts and Sciences

Professional career (1)：

Ph.D. (Univ. of Tokyo)

Work history (5)：

2023/04 - 現在 Nagoya University Department of Neuroscience and Pathobiology, Research Institute of Environmental Medicine Lecturer
2014/04 - 2023/03 Nagoya University Department of Neuroscience and Pathobiology, Research Institute of Environmental Medicine Assistant Professor
2013/11 - 2014/03 Nagoya university Department of Neuroscience and Pathobiology, Research Institute for Environmental Medicine Researcher
2012/04 - 2013/10 RIKEN Laboratory for Motor Neuron Disease, BSI Researcher
2009/04 - 2012/03 JSPS Research Fellow

Awards (2)：

2017/09 - Research Institute of Environmental Medicine, Nagoya University Young Investigator's Award
2009/03 - Graduate School of Arts & Sciences, The University of Tokyo Incentive Award, Department of Life Sciences

Association Membership(s) (3)：

THE JAPANESE SOCIETY FOR NEUROCHEMISTRY , THE JAPAN NEUROSCIENCE SOCIETY , THE JAPANESE BIOCHEMICAL SOCIETY

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