Rchr
J-GLOBAL ID：201401006197213708
Update date: Aug. 13, 2024
Megumu Saito
サイトウ メグム | Megumu Saito
Affiliation and department：
Job title：
Professor
Research field (1)：
Fetal medicine/Pediatrics
Research keywords (2)：
再生医学
, 小児の免疫学
Research theme for competitive and other funds (19)：
- 2020 - 2024 ヒト神経筋接合部モデルを用いた先天性筋無力症候群などの病態解析
- 2018 - 2021 The elucidation of neurogenesis mechanism by novel RNA binding protein Marf1, related with 16p13.11 duplication syndrome
- 2016 - 2020 Development and application of human neuromuscular junctions
- 2017 - 2019 Functional analysis of RPL5 using induced pluripotent stem cells from the patient with Diamond-Blackfan Anemia
- 2016 - 2018 Identification of a novel childhood hematopoietic failure syndrome caused by combined mutations in ADH5 and ALDH2 that function in aldehyde metabolism.
- 2015 - 2018 Exploration of the causative genes and elucidation of the pathophysiology on immune dysregulatory diseases with intractable inflammation
- 2014 - 2018 Elucidation of differentiation and function abnormalities of bone marrow mesenchymal cells using human induced pluripotent stem cell cells derived from patients with rheumatoid arthritis.
- 2014 - 2017 Establishing a platform for molecular analysis and drug innovation of auto-inflammatory disorders
- 2014 - 2017 New approach for the mechanism of ototoxic drugs against the mtDNA1555AG mutation - human iPSC and nanocarieer-
- 2013 - 2016 Detection of new molecules which induce bone lysis and new bone formation, and analysis of pathophysiology in arthropathy using induced pluripotent stem (iPS) cells
- 2013 - 2016 Disease modeling of mosaic CINCA syndrome with iPS cells
- 2012 - 2015 Exploration of the responsible gene and the pathophysiology for unidentified fever syndromes by whole genome analysis and cell-based engineering
- 2011 - 2014 Molecular mechanism on granuloma formation based on the analysis with cellular and molecular biology
- 2011 - 2012 Establishment of a novel approach to select the best iPSCs without cell cloning
- 2010 - 2012 Recapitulation of phenotypes and discovery of a novel treatment with disease-specific human ES/ iPS cells from various hereditary diseases
- 2009 - 2010 Modeling and analyzing pathogenesis of cryopyrin-associated periodic syndrome using induced pluripotent stem cells
- 2007 - 2009 Analysis of proliferation and differentiation of human embryonic stem cells and research for clinical application
- 2007 - 2008 CINCA症候群患者の臨床的解析と疾患関連CIAS1遺伝子変異の機能的解析
- 自己炎症性疾患のiPS細胞を用いた病態解析
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Papers (128)：
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Yukiko Takeda, Masahiro Ueki, Junpei Matsuhiro, Erik Walinda, Takayuki Tanaka, Masafumi Yamada, Hiroaki Fujita, Shunichiro Takezaki, Ichiro Kobayashi, Sakura Tamaki, et al. A de novo dominant-negative variant is associated with OTULIN-related autoinflammatory syndrome. The Journal of experimental medicine. 2024. 221. 6
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Kentaro Akagi, Shiro Baba, Hiroaki Fujita, Yasuhiro Fuseya, Daisuke Yoshinaga, Hirohito Kubota, Eitaro Kume, Fumiaki Fukumura, Koichi Matsuda, Takayuki Tanaka, et al. HOIL-1L deficiency induces cell cycle alteration which causes immaturity of skeletal muscle and cardiomyocytes. Scientific reports. 2024. 14. 1. 8871-8871
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Hiraku Tsujimoto, Azusa Hoshina, Shin-Ichi Mae, Toshikazu Araoka, Wang Changting, Yoshihiro Ijiri, May Nakajima-Koyama, Satoko Sakurai, Kazusa Okita, Ken Mizuta, et al. Selective induction of human renal interstitial progenitor-like cell lineages from iPSCs reveals development of mesangial and EPO-producing cells. Cell Reports. 2024. 113602-113602
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Jingxin Wang, Norikazu Saiki, Ayako Tanimura, Takafumi Noma, Akira Niwa, Tastutoshi Nakahata, Megumu K Saito. UK-5099, a mitochondrial pyruvate carrier inhibitor, recovers impaired neutrophil maturation caused by AK2 deficiency in human pluripotent stem cell models. Biochemical and biophysical research communications. 2023. 687. 149211-149211
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Megumu K. Saito, Mitsujiro Osawa, Nao Tsuchida, Kotaro Shiraishi, Akira Niwa, Knut Woltjen, Isao Asaka, Katsuhisa Ogata, Suminobu Ito, Shuzo Kobayashi, et al. A disease-specific iPS cell resource for studying rare and intractable diseases. Inflammation and Regeneration. 2023. 43. 1
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MISC (201)：
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伊佐 真彦[西谷], 向井 康治朗, 本田 吉孝, 仁平 寛士, 田中 孝之, 柴田 洋史, 日衛嶋 栄太郎, 井澤 和司, 川崎 ゆり, 大澤 光次郎, et al. Pyrinインフラマソームの過剰活性化を原因とする新たな自己炎症性疾患 CDC42 C-term病の病態解析. 日本免疫不全・自己炎症学会雑誌. 2022. 1. 2. 70-70
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齋藤 潤. 【IRUD-Beyond:小型モデル生物および患者iPS細胞を用いた希少・未診断疾患へのアプローチ】iPS細胞を用いた希少疾患遺伝子機能解析. 遺伝子医学. 2022. 12. 2. 55-59
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植松 賢司, 座波 清誉, 松本 浩, 野々山 恵章, 松本 直通, 齋藤 潤, 伊藤 正孝, 松本 志郎, 藤田 泰典, 大澤 郁朗. DNM1L変異による早期乳児てんかん性脳症患者由来iPS細胞から分化誘導した神経細胞におけるミトコンドリア形態の解析. 脳と発達. 2021. 53. Suppl. S213-S213
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山本 圭子, 大澤 光次郎, 齋藤 潤, 山本 俊至. Xq22欠失女性患者由来iPS細胞を用いた病態解析. 脳と発達. 2021. 53. Suppl. S288-S288
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齋藤 潤, 中畑 龍俊. 【免疫リプログラミングと細胞デザイン】再生医療の応用による免疫リプログラミング iPS細胞由来の樹状細胞とマクロファージを用いた医療技術の開発. 医学のあゆみ. 2020. 275. 1. 73-76
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Patents (6)：
Lectures and oral presentations (3)：
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PRULIPOTENT STEM CELL DERIVED MYELOID CELL LINES FOR DISSECTING THE MECHANISM OF AUTOINFLAMMATION.
(ISSAID2019 2019)
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PLURIPOTENT STEM CELL MODEL OF NAKAJO-NISHIMURA SYNDROME UNTANGLES PROINFLAMMATORY PATHWAYS MEDIATED BY OXIDATIVE STRESS.
(ESID2018 2018)
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MODELING AN AUTOINFLAMMATORY IMMUNOPROTEASOME DISEASE NAKAJO-NISHIMURA SYNDROME WITH HUMAN PLURIPOTENT STEM CELL-DERIVED MYELOID CELL LINES
(EULAR2018 2018)
Education (3)：
- 2004 - 2008 Kyoto University Graduate School of Medicine Department of Pediatrics
- 1991 - 1997 Kyoto University Faculty of Medicine Department of Medical Science
- - 1991 岡山県立岡山操山高等学校
Work history (8)：
- 2022/05 - 現在 京都大学iPS細胞研究所 教授
- 2012/07 - 2022/04 京都大学iPS細胞研究所 准教授
- 2011/07 - 2012/06 京都大学iPS細胞研究所 特定拠点講師
- 2009/04 - 2011/06 京都大学iPS細胞研究所 特定拠点助教
- 2007/04 - 2009/03 Japan Society for the Promotion of Science
- 2003/04 - 2004/03 静岡県立こども病院感染免疫アレルギー科 副医長
- 2002/04 - 2003/03 国立成育医療センター・手術集中治療部 レジデント
- 1997/05 - 2002/03 神戸市立中央市民病院・小児科 研修医(前期・後期)
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Association Membership(s) (7)：
国際自己炎症性疾患学会
, 日本再生医療学会
, 国際幹細胞学会
, 日本免疫不全・自己炎症学会
, 日本免疫学会
, 日本アレルギー学会
, 日本小児科学会
