Megumu Saito

サイトウメグム | Megumu Saito

Affiliation and department：
Job title： Professor

Research field (1)： Fetal medicine/Pediatrics

Research keywords (2)：再生医学 , 小児の免疫学

Research theme for competitive and other funds (18)：

2020 - 2024 ヒト神経筋接合部モデルを用いた先天性筋無力症候群などの病態解析
2018 - 2021 The elucidation of neurogenesis mechanism by novel RNA binding protein Marf1, related with 16p13.11 duplication syndrome
2016 - 2020 Development and application of human neuromuscular junctions
2017 - 2019 Functional analysis of RPL5 using induced pluripotent stem cells from the patient with Diamond-Blackfan Anemia
2015 - 2018 Exploration of the causative genes and elucidation of the pathophysiology on immune dysregulatory diseases with intractable inflammation

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Papers (121)：

Motoyasu Hosokawa, Ryuta Mikawa, Atsuko Hagiwara, Yukiko Okuno, Tomonari Awaya, Yuki Yamamoto, Senye Takahashi, Haruka Yamaki, Mitsujiro Osawa, Yasuhiro Setoguchi, et al. Cryptotanshinone is a candidate therapeutic agent for interstitial lung disease associated with a BRICHOS-domain mutation of SFTPC. iScience. 2023. 107731-107731
Naoya Kase, Yohko Kitagawa, Akihiro Ikenaka, Akira Niwa, Megumu K. Saito. A concise in vitro model for evaluating interactions between macrophage and skeletal muscle cells during muscle regeneration. Frontiers in Cell and Developmental Biology. 2023. 11. 1022081-1022081
Akihiro Ikenaka, Yohko Kitagawa, Michiko Yoshida, Chuang-Yu Lin, Akira Niwa, Tatsutoshi Nakahata, Megumu K Saito. SMN promotes mitochondrial metabolic maturation during myogenesis by regulating the MYOD-miRNA axis. Life science alliance. 2023. 6. 3
Takahiro Hayashi, Naoko Yano, Kengo Kora, Atsushi Yokoyama, Kanako Maizuru, Taisei Kayaki, Kinuko Nishikawa, Mitsujiro Osawa, Akira Niwa, Toshiki Takenouchi, et al. Involvement of mTOR pathway in neurodegeneration in NSF-related developmental and epileptic encephalopathy. Human molecular genetics. 2023. 32. 10. 1683-1697
Shigeharu Oh, Akira Niwa, Ayako Nagahashi, Isao Asaka, Tatsutoshi Nakahata, Megumu K Saito. iPS cells from Chediak-Higashi syndrome patients recapitulate the giant granules in myeloid cells. Pediatrics international : official journal of the Japan Pediatric Society. 2022. 64. 1. e15390

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MISC (200)：

齋藤潤. 【IRUD-Beyond:小型モデル生物および患者iPS細胞を用いた希少・未診断疾患へのアプローチ】iPS細胞を用いた希少疾患遺伝子機能解析. 遺伝子医学. 2022. 12. 2. 55-59
植松賢司, 座波清誉, 松本浩, 野々山恵章, 松本直通, 齋藤潤, 伊藤正孝, 松本志郎, 藤田泰典, 大澤郁朗. DNM1L変異による早期乳児てんかん性脳症患者由来iPS細胞から分化誘導した神経細胞におけるミトコンドリア形態の解析. 脳と発達. 2021. 53. Suppl. S213-S213
山本圭子, 大澤光次郎, 齋藤潤, 山本俊至. Xq22欠失女性患者由来iPS細胞を用いた病態解析. 脳と発達. 2021. 53. Suppl. S288-S288
齋藤潤, 中畑龍俊. 【免疫リプログラミングと細胞デザイン】再生医療の応用による免疫リプログラミング iPS細胞由来の樹状細胞とマクロファージを用いた医療技術の開発. 医学のあゆみ. 2020. 275. 1. 73-76
池中亮裕, 齋藤潤. ヒト多能性幹細胞に由来する機能的な神経筋接合部モデルの構築. バイオサイエンスとインダストリー. 2020. 78. 2. 112-113

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Patents (6)：

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Lectures and oral presentations (3)：

PRULIPOTENT STEM CELL DERIVED MYELOID CELL LINES FOR DISSECTING THE MECHANISM OF AUTOINFLAMMATION.
(ISSAID2019 2019)
PLURIPOTENT STEM CELL MODEL OF NAKAJO-NISHIMURA SYNDROME UNTANGLES PROINFLAMMATORY PATHWAYS MEDIATED BY OXIDATIVE STRESS.
(ESID2018 2018)
MODELING AN AUTOINFLAMMATORY IMMUNOPROTEASOME DISEASE NAKAJO-NISHIMURA SYNDROME WITH HUMAN PLURIPOTENT STEM CELL-DERIVED MYELOID CELL LINES
(EULAR2018 2018)

Education (3)：

2004 - 2008 Kyoto University Graduate School of Medicine Department of Pediatrics
1991 - 1997 Kyoto University Faculty of Medicine Department of Medical Science
- 1991 岡山県立岡山操山高等学校

Work history (8)：

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