Rchr
J-GLOBAL ID：201401042768363466
Update date: Aug. 14, 2024
Nishiyama Koichi
ニシヤマ コウイチ | Nishiyama Koichi
Affiliation and department：
Job title：
Professor
Homepage URL (1)：
http://ircms.kumamoto-u.ac.jp/research/koichi_nishiyama/
Research field (4)：
Cell biology
, Biomaterials
, Biomedical engineering
, Cardiology
Research keywords (10)：
Angiogenesis
, 微小血管ネットワーク
, Vascular endothelial cell
, pericyte
, Blood flow
, Mechanical stimuli
, vascular basement membrane
, Live imaging
, Mathematical model
, Quantitative analysis
Research theme for competitive and other funds (19)：
- 2021 - 2023 Reproduction of kidney glomerulus structure and function using human iPS cells-derived organoid and vascular chip
- 2019 - 2022 Cellular and molecular mechanisms underlying inflammation and fibrosis in pericyte-deficient retinai
- 2019 - 2022 Angiogenic machinery via concerted biomechanical control by blood flow pericyte
- 2016 - 2019 Mechanisms of irreversible breakdown of blood-retina barrier following pericyte deficiency
- 2017 - 2019 Elucidation of novel function of intravascular pressure in angiogenesis
- 2016 - 2019 Constructive understanding of the regulatory machinery of collective cell movement
- 2014 - 2019 からだの外でかたちを育てる
- 2016 - 2018 Analyses of endothelial cell dynamics in retinal angiogenesis
- 2015 - 2018 Identification of mechanisms underlying ectopic hyaloid invasion into retina in PHPV
- 2016 - 2017 マクロファージを標的とした糖尿病網膜症の抗体医薬開発
- 2012 - 2016 Establishment of the concept of broad organ-forming network in cardiovascular formation and models for tissue reconstruction
- 2014 - 2016 Development of on-chip vascular model utilizing the self-organizing ability: reconstitution-based understanding of vascular physiology and pathology
- 2013 - 2016 RhoJ-mediated regulation of endothelial cell movements and vascular patterning
- 2013 - 2015 かたちをつくる血管細胞の集団的ふるまいと制御系の理解
- 2011 - 2013 樹状構造をつくる血管内皮細胞の集合運動とその制御システム
- 2011 - 2013 Angiogenic mechanism spatio-temporally controlled by Id-Notch signal crosstalk and their therapeutic application
- 2009 - 2011 Identification of novel cell lineages contributing to cardiovascular development and clarification of mechanisms underlying their fate determination
- 2008 - 2010 Role of transcriptional factor Id in angiogenesis
- 2006 - 2007 Molecular mechanisms of Id1-induced angiogenesis and the clinical application for therapeutic angiogenesis
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Papers (69)：
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Kiyotake Yamamoto, Haruko Watanabe-Takano, Eri Oguri-Nakamura, Hitomi Matsuno, Daiki Horikami, Tomohiro Ishii, Ryuji Ohashi, Yoshiaki Kubota, Koichi Nishiyama, Takahisa Murata, et al. Rap1 small GTPase is essential for maintaining pulmonary endothelial barrier function in mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2023. 37. 12. e23310
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亀井 竣輔, 福嶋 葉子, 植村 明嘉, 有馬 勇一郎, 西山 功一, 南 敬. VEGF-NFAT-ダウン症因子-1シグナル軸を介した血管内皮分化や血管分岐制御機構の解明. 脈管学. 2023. 63. 1. 14-14
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Kazuya Fujimoto, Scott Erickson, Masamune Nakayama, Hroki Ihara, Kei Sugihara, Yuji Nashimoto, Koichi Nishiyama, Takashi Miura, Ryuji Yokokawa. Pericytes and shear stress each alter the shape of a self-assembled vascular network. Lab on a Chip. 2023. 23. 2. 306-317
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亀井 竣輔, 福嶋 葉子, 植村 明嘉, 有馬 勇一郎, 西山 功一, 南 敬. VEGF-NFAT-ダウン症因子-1シグナル軸を介した血管分岐制御機構の解明. 日本生化学会大会プログラム・講演要旨集. 2022. 95回. 3T12a-06
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春田 望智, 花田 保之, 市川 朝永, 尾関 有香, 宮崎 紬, 徐 宇卿, 有馬 勇一郎, 植村 明嘉, 白木 幸彦, 西山 功一. ペリサイトによる血管周囲基質の力学的性質変化を介した血管新生促進機構. 日本生化学会大会プログラム・講演要旨集. 2022. 95回. 2T10a-09
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MISC (88)：
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花田 保之, 西山 功一. 血管新生における血流による物理的力の役割-Roles of the mechanical forces by blood flow in angiogenesis-特集 "かたちづくり"を制御する分子メカニズム ; 形態形成と多細胞動態. 医学のあゆみ. 2024. 290. 1. 42-46
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福原茂朋, 弓削進弥, 有馬勇一郎, 花田保之, 花田三四郎, 石井智裕, 若山勇紀, 横川隆司, 三浦岳, 望月直樹, et al. 創傷治癒過程の血管新生における内腔圧の新たな役割の解明. 脈管学(Web). 2020. 60. supplement
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福原茂朋, 弓削進弥, 西山功一, 有馬勇一郎, 花田保之, 花田三四郎, 石井智裕, 若山勇紀, 辻田和也, 横川隆司, et al. 血流に起因する内腔圧による創傷治癒過程の血管新生の新たな制御機構. 日本生化学会大会(Web). 2020. 93rd
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弓削進弥, 西山功一, 有馬勇一郎, 花田保之, 花田三四郎, 石井智裕, 若山勇紀, 辻田和也, 横川隆司, 三浦岳, et al. 内腔圧の機械的刺激により制御される創傷治癒での血管新生. 日本生化学会大会(Web). 2020. 93rd
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花田三四郎, 花田保之, 花田保之, 梨本裕司, フリードル ピーター, 三浦岳, 横川隆司, 西山功一. On-chip model for cancer metastatic intravasation. 日本癌学会学術総会抄録集(Web). 2019. 78th
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Education (1)：
- 1986 - 1992 Kumamoto University School of Medicine
Professional career (1)：
- MD, PhD (Kumamoto University)
Work history (5)：
- 2021/04 - 現在 University of Miyazaki Lab. for Vascular and Cellular Dynamics, Department of Medical Sciences Professor
- 2014/04 - 2021/03 Kumamoto University International Research Center for Medical Sciences Principal investigator
- 2014 - 2016 Kumamoto University University Hospital Lecturer
- 2006/04 - 2014/03 University of Tokyo Graduate School of Medicine Assistant professor
- 2005/04 - 2006/03 The University of Tokyo Graduate School of Medicine Assistant Professor
Association Membership(s) (6)：
日本癌学会
, 日本数理生物学会
, 日本生体医工学会
, 日本生化学会
, 日本分子生物学会
, 日本血管生物医学会
