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J-GLOBAL ID：201501021011924746   Update date: Jan. 09, 2025

Ota Akinobu

オオタ アキノブ | Ota Akinobu
Affiliation and department：
Kinjo Gakuin University

About Kinjo Gakuin University


Research field  (3)： Hematology and oncology ,  Pathobiochemistry ,  Genomics
Research keywords  (6)： Innate Immunity ,  ゲノム編集 ,  多発性骨髄腫 ,  がん ,  ゲノム異常 ,  トランスクリプトーム
Research theme for competitive and other funds  (14)：
  • 2023 - 2027 癌・精巣特異的嗅覚受容体を介した癌転移機構の解明と臨床応用
  • 2023 - 2026 PBKリン酸化標的遺伝子を介した大腸癌悪性形質制御機構の解析と治療応用の可能性
  • 2024 - 2026 ウイルス性呼吸器感染症への酪酸産生菌の臨床応用に向けた基盤構築と作用機序の解明
  • 2022 - 2025 癌抑制遺伝子BAP1を標的とした胸膜中皮種新規阻害薬の開発
  • 2022 - 2025 ゲノム編集を利用したKRAS変異骨髄腫に対する新規治療標的薬の探索
Show all
Papers (95)：
  • Nushrat Jahan, Shamima Islam, Karnan Sivasundaram, Akinobu Ota, Munekazu Naito, Junpei Kuroda, Hideto Watanabe. Role of versican in extracellular matrix formation: analysis in 3D culture. American journal of physiology. Cell physiology. 2024
  • Sivasundaram Karnan, Akinobu Ota, Muhammad Nazmul Hasan, Hideki Murakami, Md. Lutfur Rahman, Md Wahiduzzaman, Md Towhid Ahmed Shihan, Nushrat Jahan, Lam Quang Vu, Ichiro Hanamura, et al. Targeting fatty acid synthase suppresses tumor development inNF2/CDKN2A-deficient malignant pleural mesothelioma. 2024
  • Sivasundaram Karnan, Ichiro Hanamura, Akinobu Ota, Lam Quang Vu, Kaori Uchino, Tomohiro Horio, Satsuki Murakami, Shohei Mizuno, Md Lutfur Rahman, Md Wahiduzzaman, et al. ARK5 enhances cell survival associated with mitochondrial morphological dynamics from fusion to fission in human multiple myeloma cells. Cell Death Discovery. 2024
  • Xuan Zhou, Hiroki Iida, Yuqiang Li, Akinobu Ota, Lisheng Zhuo, Reiko Nobuhara, Yuki Terajima, Mitsuru Naiki, A Hari Reddi, Koji Kimata, et al. Neurotropin® ameliorates chronic pain associated with scar formation in a mouse model: A gene expression analysis of the inflammatory response. Molecular Pain. 2024
  • Toshinori Hyodo, Eri Asano-Inami, Satoko Ito, Mai Sugiyama, Akihiro Nawa, Md Lutfur Rahman, Muhammad Nazmul Hasan, Yuko Mihara, Vu Quang Lam, Sivasundaram Karnan, et al. Leucine zipper protein 1 (LUZP1) regulates the constriction velocity of the contractile ring during cytokinesis. The FEBS Journal. 2023
ｍore...
MISC (105)：
  • 太田 明伸, 牧野 帆里, 吉岡 愛唯, 渡邊 由希子, 横谷 楓花, Chowdhury Sajid Iftekhar, Karnan Sivasundaram, 細川 好孝. 飽和脂肪酸が悪性中皮腫細胞の増殖に及ぼす影響の解析. 脂質栄養学. 2024. 33. 2. 134-134
  • ONODERA Kazunari, SHIMOJO Daisuke, ONODERA Kazunari, SHIMOJO Daisuke, ISHIHARA Yasuharu, OTA Akinobu, OTA Akinobu, MIYA Fuyuki, RASHID Muhammad Irfanur, ITO Takuji, et al. Elucidating early pathophysiology of spinal-bulbar muscular atrophy using disease-specific iPSCs. 日本神経学会学術大会プログラム・抄録集. 2024. 65th
  • HANAMURA Ichiro, SIVASUNDARAM Karnan, OTA Akinobu, HYODO Yoshinori, HOSOKAWA Yoshitaka, TAKAMI Akiyoshi. Exploration of candidate compounds for KRAS-mutant myeloma using isogenic cell clones with KRAS-G12A. 日本血液学会学術集会抄録(Web). 2024. 86th
  • SAKAGUCHI Momona, 木村優花, 川村千菜実, 佐伯ななみ, IFTEKHAR Chowdhury Sajid, SIVASUNDARAM Karnan, 細川好孝, 花村一朗, 太田明伸, 太田明伸. Differential effect of free fatty acids on the survival of multiple myeloma cells. International Journal of Myeloma (Web). 2024. 14. 3
  • 太田明伸, 太田明伸, 花村一朗, シバスンダラン カルナン, シバスンダラン カルナン, 武井則雄, IFTEKHAR Chowdhury Sajid, 兵頭寿典, 小西裕之, 都築忍, et al. A novel FIRRM-FIGNL1 interaction enhances the viability of multiple myeloma cells. International Journal of Myeloma (Web). 2024. 14. 3
ｍore...
Patents (4)：
Books (9)：
  • ゲノム編集技術 ~実験上のポイント/産業利用に向けた研究開発動向と安全性周知
    2023 ISBN:9784865022421
  • Toxicological Risk Assessment and Multi-System Health Impacts from Exposure
    2021 ISBN:9780323853583
  • CRISPR-Casシステムを用いたゲノム編集と骨髄腫の新たな悪性化因子の同定
    Precision Medicine 2021
  • CRISPR-Cas-mediated genome editing:Novel technology to clarify molecular mechanism contributing to malignant phenotype of multiple myeloma
    2020
  • Role of PDZ binding kinase in tumorigenesis of multiple myeloma
    2019
ｍore...
Education (2)：
  • 2006 - 2010 Sapporo Medical University Graduate School of Medicine
  • 1998 - 2002 Nagoya University Medical faculty Health Sciences
Professional career (1)：
  • 医学博士 (札幌医科大学大学院医学研究科)
Work history (6)：
  • 2023/04 - 現在 Aichi Medical University
  • 2023/04 - 現在 Kinjo Gakuin University College of Human Life and Environment Department of Food and Nutritional Environment Professor
  • 2014/04 - 2023/03 Aichi Medical University School of Medicine Department of Biochemistry Associate Professor
  • 2020/08 - 2021/01 University of Washington Department of Immunology Visiting Assistant Professor
  • 2011/01 - 2013/03 Aichi Medical University School of Medicine Department of Biochemistry Assistant Professor
Show all
Awards (1)：
  • 2018/05 - 日本骨髄腫学会 平成30年度日本骨髄腫学会奨励賞
Association Membership(s) (4)：
Japanese Society of Myeloma ,  THE JAPANESE BIOCHEMICAL SOCIETY ,  THE JAPANESE CANCER ASSOCIATION ,  THE JAPANESE SOCIETY OF HEMATOLOGY
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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