Art

J-GLOBAL ID：201502200992554729   Reference number：15A1017545

Identification of Hydroxyanthraquinones as Novel Inhibitors of Hepatitis C Virus NS3 Helicase

C型肝炎ウイルスNS3ヘリカーゼの新規阻害剤としてのヒドロキシアントラキノンの同定

Author (17)： FURUTA Atsushi (Waseda Univ., Tokyo, JPN) ,  FURUTA Atsushi (National Inst. of Advanced Industrial Sci. and Technol. (AIST), Ibaraki, JPN) ,  TSUBUKI Masayoshi (Hoshi Univ., Tokyo, JPN) ,  ENDOH Miduki (Hoshi Univ., Tokyo, JPN) ,  MIYAMOTO Tatsuki (Waseda Univ., Tokyo, JPN) ,  MIYAMOTO Tatsuki (National Inst. of Advanced Industrial Sci. and Technol. (AIST), Ibaraki, JPN) ,  TANAKA Junichi (Univ. the Ryukyus, Okinawa, JPN) ,  SALAM Kazi Abdus (Univ. Tokyo, Tokyo, JPN) ,  AKIMITSU Nobuyoshi (Univ. Tokyo, Tokyo, JPN) ,  TANI Hidenori (Waseda Univ., Tokyo, JPN) ,  YAMASHITA Atsuya (Univ. Yamanashi, Yamanashi, JPN) ,  MORIISHI Kohji (Univ. Yamanashi, Yamanashi, JPN) ,  NAKAKOSHI Masamichi (Toho Univ., Chiba, JPN) ,  SEKIGUCHI Yuji (National Inst. of Advanced Industrial Sci. and Technol. (AIST), Ibaraki, JPN) ,  TSUNEDA Satoshi (Waseda Univ., Tokyo, JPN) ,  NODA Naohiro (Waseda Univ., Tokyo, JPN) ,  NODA Naohiro (National Inst. of Advanced Industrial Sci. and Technol. (AIST), Ibaraki, JPN)
Material： International Journal of Molecular Sciences (Web)  (Int J Mol Sci (Web))
Volume： 16  Issue： 8  Page： 18439-18453 (WEB ONLY)  Publication year： Aug. 2015 
JST Material Number： U7038A  ISSN： 1422-0067  CODEN： IJMCFK  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Thesaurus term： hepatitis C virus ,  viral protein ,  enzyme ,  *enzyme inhibitor ,  *quinone ,  *polynuclear aromatic compound ,  liver cirrhosis ,  hepatoma ,  enzyme activity ,  viral replication ,  *antiviral drug ,  anthracycline antibiotics ,  toxicity test ,  concentration(ratio) ,  molecular structure ,  aromatic amine ,  polyphenol ,  aminoalcohol ,  diamine ,  secondary amine ,  aromatic ketone ,  diketone ,  hydroxy ketone
Semi thesaurus term： NS3 ,  helicase ,  *Anthraquinones ,  IC50 ,  chemical structure

JST classification (3)： Basic research of antiviral drugs  (GW17040O) ,  Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W) ,  Aromatic monocyclic phenols and polyphenols  (CF05090V)

Substance index (3)： Mitoxantrone ,  Hypericin ,  Sennidin A

Terms in the title (5)： C型肝炎ウイルス ,  NS3 ,  ヘリカーゼ ,  阻害剤 ,  同定