Art

J-GLOBAL ID：201502215081095350   Reference number：15A1080370

Synthesis of new opioid derivatives with a propellane skeleton and their pharmacologies: Part 5, novel pentacyclic propellane derivatives with a 6-amide side chain

プロペラン骨格を有する新規オピオイド誘導体の合成とこれらの薬理学:5. 6-アミド側鎖を有する新規五環式プロペラン誘導体

Author (9)： NAKAJIMA Ryo (Graduate School of Pure and Applied Sciences, Univ. of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8571, JPN) ,  YAMAMOTO Naoshi (International Inst. for Integrative Sleep Medicine (WPI-IIIS), Univ. of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki ...) ,  HIRAYAMA Shigeto (School of Pharmacy, Kitasato Univ., 5-9-1, Shirokane, Minato-ku, Tokyo 108-8641, JPN) ,  IWAI Takashi (School of Pharmacy, Kitasato Univ., 5-9-1, Shirokane, Minato-ku, Tokyo 108-8641, JPN) ,  SAITOH Akiyoshi (Dep. of Neuropsychopharmacology, National Inst. of Mental Health, National Center of Neurology and Psychiatry, Tokyo ...) ,  NAGUMO Yasuyuki (International Inst. for Integrative Sleep Medicine (WPI-IIIS), Univ. of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki ...) ,  FUJII Hideaki (School of Pharmacy, Kitasato Univ., 5-9-1, Shirokane, Minato-ku, Tokyo 108-8641, JPN) ,  NAGASE Hiroshi (Graduate School of Pure and Applied Sciences, Univ. of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8571, JPN) ,  NAGASE Hiroshi (International Inst. for Integrative Sleep Medicine (WPI-IIIS), Univ. of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki ...)
Material： Bioorganic & Medicinal Chemistry  (Bioorganic and Medicinal Chemistry)
Volume： 23  Issue： 19  Page： 6271-6279  Publication year： Oct. 01, 2015 
JST Material Number： W0556A  ISSN： 0968-0896  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： analgesic ,  *analgesic action ,  *propellane ,  *narcotic analgesic ,  mu receptor ,  kappa receptor ,  *bridged compound ,  *sedative action ,  dependence ,  pharmacology ,  proton magnetic resonance ,  Electrospray Ionization Mass Spectrometry
Semi thesaurus term： 1H-NMR ,  ESI-MS ,  kappa opioid receptor ,  mu opioid receptor ,  opioid ,  *opioid analgesics ,  analgesic ,  dosage dependence

JST classification (3)： Bridged tri-or more-cyclic carbocyclic compounds  (CF06110B) ,  Synthesis of drugs  (GV01030F) ,  Basic research of antipyretic analgesics  (GW03040H)

Substance index (2)： TRK-820 ,  3,5′-[1-[Methyl[(E)-3-(3-furyl)acryloyl]amino]ethane-1,2-diyl]-3,2′-[3-(cyclopropylmethyl)-3-azapropane-1,3-diyl]spiro[indan-2,1′-[3]cyclohexene]-5-ol

Terms in the title (8)： プロペラン ,  骨格 ,  オピオイド ,  誘導体 ,  薬理学 ,  アミド ,  側鎖 ,  環