Rchr
J-GLOBAL ID:201601000773957030   Update date: Sep. 14, 2024

SUGA Hiroaki

SUGA Hiroaki
Affiliation and department:
Research field  (1): Bioorganic chemistry
Research theme for competitive and other funds  (29):
  • 2020 - 2025 Challenges to the remaining issues of therapeutically valuable pseudo-natural peptides and products
  • 2022 - 2024 抗KRAS環状ペプチドファマコフォアの小型タンパク質へのラソグラフト体の創出
  • 2016 - 2022 Redesigning Biosynthetic Machineries (International Activity Support Team)
  • 2016 - 2021 Synthetic biology of pseudo-natural products by artificial in vitro biosynthesis
  • 2016 - 2021 Redesigning Biosynthetic Machineries (Project Team)
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Papers (285):
  • Nichole Marcela Rojas-Chaverra, Ryu Imamura, Hiroki Sato, Toby Passioura, Emiko Mihara, Tatsunori Nishimura, Junichi Takagi, Hiroaki Suga, Kunio Matsumoto, Katsuya Sakai. A cyclic peptide-grafted Fc with hepatocyte growth factor functionality ameliorates hepatic fibrosis in a non-alcoholic steatohepatitis mouse model. iScience. 2024. 27. 8. 110426-110426
  • Sumika Inoue, Dinh Thanh Nguyen, Keisuke Hamada, Rika Okuma, Chikako Okada, Masahiro Okada, Ikuro Abe, Toru Sengoku, Yuki Goto, Hiroaki Suga. De Novo Discovery of Pseudo-Natural Prenylated Macrocyclic Peptide Ligands. Angewandte Chemie International Edition. 2024
  • Alexander A Vinogradov, Yue Zhang, Keisuke Hamada, Shunsuke Kobayashi, Kazuhiro Ogata, Toru Sengoku, Yuki Goto, Hiroaki Suga. A Compact Reprogrammed Genetic Code for De Novo Discovery of Proteolytically Stable Thiopeptides. Journal of the American Chemical Society. 2024. 146. 12. 8058-8070
  • Wei Lu, Naohiro Terasaka, Yuriko Sakaguchi, Takeo Suzuki, Tsutomu Suzuki, Hiroaki Suga. An anticodon-sensing T-boxzyme generates the elongator nonproteinogenic aminoacyl-tRNA in situ of a custom-made translation system for incorporation. Nucleic Acids Research. 2024
  • Takashi Miura, Tika R Malla, Lennart Brewitz, Anthony Tumber, Eidarus Salah, Kang Ju Lee, Naohiro Terasaka, C David Owen, Claire Strain-Damerell, Petra Lukacik, et al. Cyclic β2,3-amino acids improve the serum stability of macrocyclic peptide inhibitors targeting the SARS-CoV-2 main protease. Bulletin of the Chemical Society of Japan. 2024
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MISC (58):
  • Takayuki Katoh, Hiroaki Suga. Development of bioactive foldamers using ribosomally synthesized nonstandard peptide libraries#. Bulletin of the Chemical Society of Japan. 2021. 94. 2. 549-557
  • Alexander A. Vinogradov, Hiroaki Suga. Introduction to Thiopeptides: Biological Activity, Biosynthesis, and Strategies for Functional Reprogramming. Cell Chemical Biology. 2020. 27. 8. 1032-1051
  • Koki Shinbara, Wenyu Liu, Renier Herman Pieter van Neer, Takayuki Katoh, Hiroaki Suga. Methodologies for Backbone Macrocyclic Peptide Synthesis Compatible With Screening Technologies. Frontiers in Chemistry. 2020. 8
  • 尾崎太郎, 尾崎太郎, 菅井佳宣, 浅水俊平, 尾仲宏康, 後藤佑樹, 菅裕明, 池田治生. Dissection of goadsporin biosynthetic machinery by in vitro reconstitution leading to in vivo production of designer analogues. Institute for Fermentation, Osaka. Research Communications. 2018. 32
  • 菅井佳宣, 菅井佳宣, 尾崎太郎, 尾崎太郎, 浅水俊平, 尾仲宏康, 菅裕明, 後藤佑樹. Analysis of lanthipeptide biosynthetic enzymes responsible for formation of novel goadionin structure. Institute for Fermentation, Osaka. Research Communications. 2018. 32
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Patents (38):
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