Art

J-GLOBAL ID：201602236171909384   Reference number：16A0909313

Structure-activity relationships of dibenzoylhydrazines for the inhibition of P-glycoprotein-mediated quinidine transport

P糖蛋白質によって媒介されるキニジン輸送の阻害のためのジベンゾイルヒドラジン類の構造活性相関

Author (7)： Miyata Ken-ichi (Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan) ,  Miyata Ken-ichi (Otsuka Pharmaceutical Co., Ltd, Tokushima 771-0182, Japan) ,  Nakagawa Yoshiaki (Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan) ,  Kimura Yasuhisa (Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan) ,  Ueda Kazumitsu (Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan) ,  Ueda Kazumitsu (Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, Kyoto 606-8502, Japan) ,  Akamatsu Miki (Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan)
Material： Bioorganic & Medicinal Chemistry  (Bioorganic and Medicinal Chemistry)
Volume： 24  Issue： 14  Page： 3184-3191  Publication year： Jul. 15, 2016 
JST Material Number： W0556A  ISSN： 0968-0896  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： *P glycoprotein ,  *Biological Transport ,  *vic-polynitrogen compound ,  *aromatic carboxylic acid ,  *Quantitative Structure-Activity Relationship ,  substrate (biochemistry) ,  *inhibition ,  docking ,  Computer Simulation ,  electronic effect ,  steric effect ,  substituent effect ,  modeling ,  molecular structure ,  molecular model ,  binding site ,  cultured cell ,  Molecular Docking Simulation ,  *transmembrane protein ,  computer application ,  utilization ,  alcohol ,  nitrogen heterocyclic compound ,  bridged compound ,  vinyl compound ,  quinoline alkaloid ,  phenol ether ,  polynuclear aromatic compound
Semi thesaurus term： *ジベンゾイルヒドラジン誘導体 ,  蛋白質モデリング ,  LLC-GA5-COL150細胞

Author keywords (5)： P-glycoprotein ,  Dibenzoylhydrazines ,  Structure-activity ,  Docking ,  Bidirectional transport assay

JST classification (4)： Synthesis of drugs  (GV01030F) ,  Structure-activity relationship of drugs  (GV01050B) ,  Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Basic oncology in general  (GE02010R)

Substance index (15)： Quinidine ,  N-tert-Butyl-N′-(2-methylbenzoyl)-3,5-dimethylbenzhydrazide ,  N-tert-Butyl-N′-(3-methylbenzoyl)-3,5-dimethylbenzhydrazide ,  N-tert-Butyl-N′-(3-methoxybenzoyl)-3,5-dimethylbenzhydrazide ,  N-tert-Butyl-N′-(3-ethoxybenzoyl)-3,5-dimethylbenzhydrazide ,  N-tert-Butyl-N′-(4-propylbenzoyl)-3,5-dimethylbenzhydrazide ,  N-tert-Butyl-N′-(2-phenylbenzoyl)-2-chlorobenzhydrazide ,  N-tert-Butyl-N′-(3-chlorobenzoyl)-2-chlorobenzhydrazide ,  N-tert-Butyl-N′-[3-(trifluoromethyl)benzoyl]-2-chlorobenzhydrazide ,  N-tert-Butyl-N′-(3-nitrobenzoyl)-2-chlorobenzhydrazide ,  N-tert-Butyl-N′-(2,5-dimethylbenzoyl)-2-chlorobenzhydrazide ,  N-tert-Butyl-N′-(2,5-dichlorobenzoyl)-2-chlorobenzhydrazide ,  N-tert-Butyl-N′-(3-iodobenzoyl)-2-chlorobenzhydrazide ,  N-tert-Butyl-N′-(3-bromobenzoyl)-2-chlorobenzhydrazide ,  N-tert-Butyl-N′-(4-propylbenzoyl)-2-chlorobenzhydrazide

Terms in the title (6)： P糖蛋白質 ,  キニジン ,  輸送 ,  阻害 ,  ジベンゾイルヒドラジン ,  構造活性相関