Art

J-GLOBAL ID：201602246461658210   Reference number：16A0643979

Receptor tyrosine kinase-like orphan receptor 1, a target of NKX2-1/TTF-1 lineage-survival oncogene, inhibits apoptosis signal-regulating kinase 1-mediated pro-apoptotic signaling in lung adenocarcinoma

NKX2-1/TTF-1リネジ生存癌遺伝子の標的である受容体チロシンキナーゼ様オーファン受容体1は,肺腺癌におけるアポトーシスシグナル調節キナーゼ1介在アポトーシスシグナル伝達を阻害する

Author (7)： Ida Lisa (Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan) ,  Yamaguchi Tomoya (Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan) ,  Yanagisawa Kiyoshi (Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan) ,  Kajino Taisuke (Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan) ,  Shimada Yukako (Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan) ,  Suzuki Motoshi (Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan) ,  Takahashi Takashi (Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan)
Material： Cancer Science (Web)  (Cancer Sci (Web))
Volume： 107  Issue： 2  Page： 155-161  Publication year： 2016 
JST Material Number： U0505A  ISSN： 1349-7006  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： oncogene ,...
Semi thesaurus term： cellular signal transduction ,...

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Author keywords (5)： Apoptosis ,  apoptosis signal-regulating kinase 1 ,  lung cancer ,  orphan receptor 1 ,  thyroid transcription factor 1

JST classification (3)： Basic oncology in general  (GE02010R) ,  Tumors(=neoplasms)of respiratory system  (GI04000G) ,  Receptors on cell membrane  (EF04030C)

Reference (34)：

• Tanaka H, Yanagisawa K, Shinjo K et al. Lineage-specific dependency of lung adenocarcinomas on the lung development regulator TTF-1. Cancer Res 2007; 67: 6007-11.
• Osada H, Tatematsu Y, Yatabe Y, Horio Y, Takahashi T. ASH1 gene is a specific therapeutic target for lung cancers with neuroendocrine features. Cancer Res 2005; 65: 10680-5.
• Osada H, Tomida S, Yatabe Y et al. Roles of achaete-scute homologue 1 in DKK1 and E-cadherin repression and neuroendocrine differentiation in lung cancer. Cancer Res 2008; 68: 1647-55.
• Nishikawa E, Osada H, Okazaki Y et al. miR-375 is activated by ASH1 and inhibits YAP1 in a lineage-dependent manner in lung cancer. Cancer Res 2011; 71: 6165-73.
• Garraway LA, Sellers WR. From integrated genomics to tumor lineage dependency. Cancer Res 2006; 66: 2506-8.

Terms in the title (11)： Nkx2-1 ,  TTF-1 ,  生存 ,  癌遺伝子 ,  標的 ,  受容体チロシンキナーゼ様オーファン受容体 ,  肺腺癌 ,  アポトーシスシグナル調節キナーゼ1 ,  アポトーシス ,  シグナル伝達 ,  阻害