Art

J-GLOBAL ID：201602288709680289   Reference number：16A1169099

NF-κB activation via MyD88-dependent Toll-like receptor signaling is inhibited by trichothecene mycotoxin deoxynivalenol

MyD88依存性Toll様受容体シグナル伝達系を介するNF-κB活性化は,トリコテセン系マイコトキシンであるデオキシニバレノールにより阻害される。

Author (10)： Sugiyama Kei-ichi (Division of Genetics and Mutagenesis, National Institute of Health Sciences) ,  Muroi Masashi (Research Institute of Pharmaceutical Sciences, Musashino University) ,  Kinoshita Mawo (Division of Genetics and Mutagenesis, National Institute of Health Sciences) ,  Kinoshita Mawo (Department of Applied Biological Chemistry, Faculty of Agriculture, Tamagawa University) ,  Hamada Osamu (Division of Genetics and Mutagenesis, National Institute of Health Sciences) ,  Hamada Osamu (Department of Applied Biological Chemistry, Faculty of Agriculture, Tamagawa University) ,  Minai Yuji (Department of Applied Biological Chemistry, Faculty of Agriculture, Tamagawa University) ,  Sugita-Konishi Yoshiko (Department of Food and Life Sciences, Azabu University) ,  Kamata Yoichi (Department of Veterinary Science, Faculty of Agriculture, Iwate University) ,  Tanamoto Ken-ichi (Research Institute of Pharmaceutical Sciences, Musashino University)
Material： Journal of Toxicological Sciences  (日本毒性学会学術年会プログラム・要旨集)
Volume： 41  Issue： 2  Page： 273-279(J-STAGE)  Publication year： 2016 
JST Material Number： Z0265B  ISSN： 0388-1350  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *Toll like receptor ,...
Semi thesaurus term： *cellular signal transduction ,...

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Author keywords (4)： Toll-like receptor ,  MyD88 ,  Deoxynivalenol ,  Macrophage

JST classification (5)： Toxicity of microorganism derived substances  (GZ03030F) ,  Toxicity of organic compounds  (GZ02030Y) ,  Infectious diseases,parasitics diseases in general.  (GD01010H) ,  Immunological reaction in general  (ED03010T) ,  Cell physiology in general  (EF02010S)

Substance index (1)： Deoxynivalenol

Reference (42)：

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• Bennett, J.W. and Klich, M. (2003): Mycotoxins. Clin. Microbiol. Rev., 16, 497-516.
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• Boockvar, K.S., Granger, D.L., Poston, R.M., Maybodi, M., Washington, M.K., Hibbs, J.B.Jr. and Kurlander, R.L. (1994): Nitric oxide produced during murine listeriosis is protective. Infect. Immun., 62, 1089-1100.
• Chen, Z., Hagler, J., Palombella, V.J., Melandri, F., Scherer, D., Ballard, D. and Maniatis, T. (1995): Signal-induced site-specific phosphorylation targets IκBα to the ubiquitin-proteasome pathway. Genes Dev., 9, 1586-1597.

Terms in the title (9)： MyD88 ,  依存性 ,  Toll様受容体 ,  シグナル伝達系 ,  活性化 ,  トリコテセン系 ,  マイコトキシン ,  デオキシニバレノール ,  阻害