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J-GLOBAL ID：201702247076959461   Reference number：17A0571001

Proteomic analysis of valproic acid-induced embryotoxicity in cultured post-implantation rat embryos

培養した着床後のラット胚における,バルプロ酸誘発胚毒性のプロテオーム解析

Author (10)： Usami Makoto (Division of Pharmacology, National Institute of Health Sciences) ,  Takamatsu Mina (School of Veterinary Medicine, Azabu University) ,  Kazama Shugo (School of Veterinary Medicine, Azabu University) ,  Mitsunaga Katsuyoshi (School of Pharmaceutical Sciences, Toho University) ,  Miyajima Atsuko (Division of Medical Devices, National Institute of Health Sciences) ,  Irie Tomohiko (Division of Pharmacology, National Institute of Health Sciences) ,  Doi Osamu (Laboratory of Animal Reproduction, United Graduate School of Agricultural Science, Gifu University) ,  Takizawa Tatsuya (School of Veterinary Medicine, Azabu University) ,  Nagi Teruko (Division of Pharmacology, National Institute of Health Sciences) ,  Sunouchi Momoko (Division of Pharmacology, National Institute of Health Sciences)
Material： Fundamental Toxicological Sciences (Web)  (Fundam Toxicol Sci (Web))
Volume： 4  Issue： 1  Page： 31-35(J-STAGE)  Publication year： 2017 
JST Material Number： U0596A  ISSN： 2189-115X  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *Rattus ,...
Semi thesaurus term： proteome analysis ,...

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Author keywords (4)： Valproic acid ,  Embryotoxicity ,  Proteomics ,  Rat

JST classification (3)： Toxicity of organic compounds  (GZ02030Y) ,  Basic gynecology and obstetrics  (GS01020L) ,  Cell physiology in general  (EF02010S)

Substance index (1)： Valproic acid

Reference (10)：

• Guest, I., Buttar, H.S., Smith, S. and Varma, D.R. (1994): Evaluation of the rat embryo culture system as a predictive test for human teratogens. Can. J. Physiol. Pharmacol., 72, 57-62.
• Jain, E., Bairoch, A., Duvaud, S., Phan, I., Redaschi, N., Suzek, B.E., Martin, M.J., McGarvey, P. and Gasteiger, E. (2009): Infrastructure for the life sciences: design and implementation of the UniProt website. BMC Bioinformatics, 10, 136.
• Kao, J., Brown, N.A., Schmid, B., Goulding, E.H. and Gabro, S. (1981): Teratogenicity of valproic acid: in vivo and in vitro investigaitons. Teratog. Carcinog. Mutagen., 1, 367-382.
• Klug, S., Lewandowski, C., Zappel, F., Merker, H.-J., Nau, H. and Neubert, D. (1990): Effects of valproic acid, some of its metabolites and analogues on prenatal development of rats in vitro and comparison with effects in vivo. Arch. Toxicol., 64, 545-553.
• Schardein, J.L. and Macina, O.T. (2007): Valproic acid. In Human Developmental Toxicants: Aspects of Toxicology and Chemistry pp.221-231. CRC Press, Boca Raton, Florida.

Terms in the title (8)： 培養 ,  着床 ,  ラット ,  胚 ,  バルプロ酸 ,  誘発 ,  胚毒性 ,  プロテオーム解析