Shintaku Hirofumi

Affiliation and department：
Job title： Professor
Other affiliations (1)：

RIKEN Cluster for Pioneering Research RIKEN Hakubi Research Team Leader

Homepage URL (1)： https://www.hshintaku.com/

Research field (3)： Nanobioscience , Biophysics , Fluid engineering

Research keywords (4)： RNA , Microfluidics , MEMS , Fluid Engineering

Research theme for competitive and other funds (14)：

2021 - 2024 ナノ電気穿孔を用いた1細胞ダイナミクス計測法の創成
2021 - 2023 ヘテロな肝細胞の生理学的役割分担の解明と創薬や医療への応用
2019 - 2022 Electrophoretic analysis on cytoplasmic molecules and organelles in single cells using microfluidic fractionation
2019 - 2021 1細胞RNA輸送ダイナミクス
2014 - 2019 Micro and nano electroporation for direct delivery of molecules to cell nucleus

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Papers (65)：

Jianming Chen, Arata Tsuchida, Ali D. Malay, Kousuke Tsuchiya, Hiroyasu Masunaga, Yui Tsuji, Mako Kuzumoto, Kenji Urayama, Hirofumi Shintaku, Keiji Numata. Replicating shear-mediated self-assembly of spider silk through microfluidics. Nature Communications. 2024. 15. 1
Yuji Nashimoto, An Konno, Takuto Imaizumi, Kaori Nishikawa, Kosuke Ino, Takeshi Hori, Hirokazu Kaji, Hirofumi Shintaku, Masafumi Goto, Hitoshi Shiku. Microfluidic vascular formation model for assessing angiogenic capacities of single islets. Biotechnology and bioengineering. 2023
Misa Minegishi, Takahiro Kuchimaru, Kaori Nishikawa, Takayuki Isagawa, Satoshi Iwano, Kei Iida, Hiromasa Hara, Shizuka Miura, Marika Sato, Shigeaki Watanabe, et al. Secretory GFP reconstitution labeling of neighboring cells interrogates cell-cell interactions in metastatic niches. Nature Communications. 2023. 14. 1
Kotaro Hirano, Masaki Tsuchiya, Akifumi Shiomi, Seiji Takabayashi, Miki Suzuki, Yudai Ishikawa, Yuya Kawano, Yutaka Takabayashi, Kaori Nishikawa, Kohjiro Nagao, et al. The mechanosensitive ion channel PIEZO1 promotes satellite cell function in muscle regeneration. Life Science Alliance. 2022. 6. 2. e202201783-e202201783
Maik Herbig, Akihiro Isozaki, Dino Di Carlo, Jochen Guck, Nao Nitta, Robert Damoiseaux, Shogo Kamikawaji, Eigo Suyama, Hirofumi Shintaku, Angela Ruohao Wu, et al. Best practices for reporting throughput in biomedical research. Nature methods. 2022. 19. 6. 633-634

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MISC (8)：

中山雅宗, 梨本裕司, 國田樹, 中益朗子, 鳥澤勇介, 新宅博文, 小寺秀俊, 西山功一, 三浦岳, 横川隆司. 圧力駆動流によるオンチップ血管新生の促進-Angiogenic Sprouting from On-Chip Vascular Networks by a Pressure-Driven Flow. 「センサ・マイクロマシンと応用システム」シンポジウム論文集電気学会センサ・マイクロマシン部門 [編]. 2016. 33. 1-5
S. P. Subramaniyan, M. C. Tarhan, S. L. Karsten, H. Fujita, H. Shintaku, H. Kotera, R. Yokokawa. Detection of mutations in the binding domain of tau protein by kinesin-microtubule gliding assay. Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS). 2014. 314-317
Nagendra Kumar Kamisetty, Junya Ikuta, Hirofumi Shintaku, Hidetoshi Kotera, Ryuji Yokokawa, Ryuji Yokokawa. Manipulation of microtubles motility using electrical filed on kiensin/dynein coated surfaces. 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013. 2013. 2. 811-813
Junya Ikuta, Nagendra K. Kamisetty, Hirofumi Shintaku, Hidetoshi Kotera, Ryuji Yokokawa, Ryuji Yokokawa. Microtubule gliding at the boundary of kinesin and dynein patterned surface. 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013. 2013. 3. 1454-1456
Tasuku Nakahara, Naoto Isozaki, Suguru Ando, Nagendra K. Kamisetty, Hirofumi Shintaku, Hidetoshi Kotera, Ryuji Yokokawa, Ryuji Yokokawa. Microtubule manipulation by an electric field in a fused silica channel. 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013. 2013. 1. 161-163

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Patents (7)：

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Lectures and oral presentations (79)：

Development of image analysis with nanometer resolution for evaluation of the flexural rigidity and the growth rate of microtubules
(「センサ・マイクロマシンと応用システム」シンポジウム論文集電気学会センサ・マイクロマシン部門 [編] 2017)
Development of a nano-patterning of motor proteins by integration of Au nano-pillars and SAM
(「センサ・マイクロマシンと応用システム」シンポジウム論文集電気学会センサ・マイクロマシン部門 [編] 2017)
Selective immobilization of different motor proteins by using Aqueous Two-Phase System(ATPS)
(「センサ・マイクロマシンと応用システム」シンポジウム論文集電気学会センサ・マイクロマシン部門 [編] 2017)
Evaluation of Angiogenesis on 3D Vasculature through Detection and Transduction of Shear Stress
(「センサ・マイクロマシンと応用システム」シンポジウム論文集電気学会センサ・マイクロマシン部門 [編] 2017)
Single molecule observation of fluorescent labelled ATP in microtubule gliding motility using LZMWs
(「センサ・マイクロマシンと応用システム」シンポジウム論文集電気学会センサ・マイクロマシン部門 [編] 2017)

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Education (2)：

2002 - 2006 Kyoto University Graduate School of Engineering Mechanical Engineering
1998 - 2002 Kyoto University Faculty of Engineering School of Engineering Science

Professional career (1)：

Dr. Eng. (Kyoto University)

Work history (6)：

2023/04 - 現在 Kyoto University Institute for Life and Medical Sciences Professor
2018/04 - 現在 RIKEN Cluster for Pioneering Research RIKEN Hakubi Team Leader
2012/04 - 2018/03 Kyoto University Graduate School of Engineering Assistant Professor
2007/04 - 2012/03 Osaka University Graduate School of Engineering Science Assistant Professor
2006/10 - 2007/03 Osaka University Graduate School of Engineering Science Research Associate

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Awards (8)：

2022/02 - 日本機械学会マイクロ・ナノ工学部門優秀講演論文表彰トランスクリプトーム解析を組み合わせた細胞膜の機械特性計測
2018/08 - 第三回ImPACT-シスメックス技術交流会シスメックス賞
2016/03 - 内閣府革新的研究開発推進プログラム「セレンディピティの計画的創出による新価値創造」第一回ImPACT Serendipiter Award
2014/10 - 日本機械学会マイクロ・ナノ工学部門優秀講演論文表彰分子濃縮によるオンチップ電気穿孔法の効率化
2011/08 - 大阪大学大阪大学功績賞

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Association Membership(s) (3)：

THE BIOPHYSICAL SOCIETY OF JAPAN , THE INSTITUTE OF ELECTRICAL ENGINEERS OF JAPAN , THE JAPAN SOCIETY OF MECHANICAL ENGINEERS

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