Rchr
J-GLOBAL ID:201801018547619778
Update date: Sep. 11, 2025
Yoku Hayakawa
ハヤカワ ヨク | Yoku Hayakawa
Affiliation and department:
Homepage URL (1):
https://gastro.m.u-tokyo.ac.jp/
Research field (3):
Tumor biology
, Molecular biology
, Gastroenterology
Research keywords (5):
Tumor microenvironment
, Gastrointestinal stem cell
, Colon cancer
, Gastric cancer
, Gastroenterology
Research theme for competitive and other funds (25):
- 2025 - 2028 代謝とエピゲノムを基軸とした肝内胆管発癌機構の解明と新規治療標的の探索
- 2025 - 2028 Elucidation of the Mechanism by which Dedifferentiation of Gastrointestinal Tuft Cells Leads to Cancer Initiation
- 2024 - 2027 ヒト胃粘膜内免疫応答の網羅解析を利用した個別化発癌予測モデルの確立
- 2024 - 2027 Intestinal epithelial homeostasis regulated by Paneth cell metaplasia during mucosal injury
- 2024 - 2026 Next-generation molecular profiling of gastric atrophy and regeneration utilizing spatial transcriptomics and whole-mount imaging
- 2023 - 2026 線維芽細胞系譜追跡によるクローン病線維化の起源解明
- 2023 - 2026 胃癌細胞におけるBclxl依存的Wnt活性化機序解明と治療応用
- 2023 - 2026 Research for gut microbiota-related pathology of human gastric cancer stem cells
- 2023 - 2026 異常糖鎖とゴルジ体ストレス反応を標的とした新規胃癌抗腫瘍療法の開発
- 2021 - 2024 Homeostasis and regeneration of intestinal epithelium regulated by goblet cell lineage
- 2021 - 2024 Stromal epithelial crosstalk during small intestinal development by Dlk1.
- 2021 - 2023 Simultaneous lineage tracing of multiple gastric stem cells and their paracrine regulation by stem cell niche
- 2020 - 2023 Mechanism of gastrin-dependent conversion of human stomach stem cells to intestinal metaplasia / gastric cancer origin cells
- 2020 - 2023 Single cell profiling of GI cancer-initiating cells and their niche
- 2020 - 2022 Acquired immunity and regulatory mechanism in non-H.pylori gastritis
- 2018 - 2021 Role of gut microbiota for small intestinal ulcer diseases
- 2017 - 2021 胃発癌過程における胃内細菌叢変化と、消化管内連関を介した下部消化管への影響および神経関連シグナルとの相互作用の解明
- 2017 - 2020 The effects of Dysbiosis on intestinal stem cells, inflammation, and cancer
- 2018 - 2020 アドレナリン依存性内皮細胞Immunogenic reprogrammingによる腫瘍免疫制御機構と治療応用
- 2017 - 2020 Regulatory mechanism of gastric differentiation from gastric stem cells
- 2016 - 2019 Role of RhoA mutation in diffuse type gastric cancer development
- 2017 - 2018 胃癌発生分子メカニズムの網羅的解析
- 2016 - 2018 神経・血管内皮ネットワークによる胃癌制御機構の網羅的解析と治療応用
- 2016 - 2017 印環細胞型胃癌に対する抗炎症剤による腫瘍抑制効果の検討
- 2012 - 2014 胃癌における腫瘍関連線維芽細胞を対象にした新規治療標的因子の探索
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Papers (150):
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Junya Arai, Yoku Hayakawa, Nobumi Suzuki, Hiroto Kinoshita, Masahiro Hata, Ken Kurokawa, Yuki Matsushita, Sohei Abe, Yukiko Oya, Mayo Tsuboi, et al. ARID1A mutation drives gastric tumorigenesis via activating type 2 immune dominant microenvironment. iScience. 2025
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Hiroto Kinoshita, Guodong Lian, Yoku Hayakawa. Gastric Cancer Origins: Stem Cells, Metaplasia, and Environmental Interactions. Cancer prevention research (Philadelphia, Pa.). 2025. 18. 5. 257-259
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Yu Miyakawa, Yuki Ishigaki, Nobumi Suzuki, Go Endo, Chisaki Suzumori, Takeshi Hayashi, Kenji Tamada, Takuma Iwata, Gota Fujisawa, Yoku Hayakawa, et al. Rare Case of Severe Pancreatitis induced by Encorafenib and Cetuximab in BRAF V600E-Positive Colorectal Cancer. Internal medicine (Tokyo, Japan). 2025
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Junya Arai, Yusuke Iwata, Ayumu Tsubosaka, Hiroto Kinoshita, Shintaro Shinohara, Sohei Abe, Toshiro Shiokawa, Katsuyuki Oura, Nobumi Suzuki, Masahiro Hata, et al. Muc6 -expressing gastric isthmus progenitors contribute to regeneration and metaplasia supported by myeloid-mesenchymal interactions. Biorxiv. 2025
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Ruhong Tu, Hualong Zheng, Biyun Zheng, Qing Zhong, Jin Qian, Feijing Wu, Toshiro Shiokawa, Yosuke Ochiai, Hiroki Kobayashi, Quin T Waterbury, et al. Tff2 marks gastric corpus progenitors that give rise to pyloric metaplasia/SPEM following injury. bioRxiv : the preprint server for biology. 2025
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MISC (180):
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土屋 輝一郎, 早河 翼, 福田 晃久, 大島 浩子. 座談会 消化器発がん研究からみた消化器がん克服への挑戦. 消化器病学サイエンス = Science of gastroenterology / 「消化器病学サイエンス」編集委員会 編. 2025. 9. 2. 61-68
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新倉量太, 新倉量太, 早河翼, 河合隆, 藤城光弘. Non-Helicobacter pylori細菌と胃発癌との関連:メタボローム解析による発癌機序探索. 日本ヘリコバクター学会誌. 2025. 26. 2
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岩田祐典, 早河翼, 塩川俊郎, 塩見千尋, 村上恵太, 黒川憲, 井原聡三郎, 鈴木伸三, 木下裕人, 藤城光弘. 迷走神経路による胃粘膜障害感知システムと恒常性維持機構の解析. 日本消化器病学会雑誌(Web). 2025. 122
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藤澤剛太, 林猛志, 玉田健次, 岩田琢磨, 宮川佑, 鈴木伸三, 早河翼, 藤城光弘. 小腸腺癌の分子生物学的特徴と化学療法の有効性について. 日本消化器病学会雑誌(Web). 2025. 122
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村上恵太, 井原聡三郎, 新井絢也, 早河翼, 藤城光弘. 腸管ベーチェット病の長期予後と再燃例の予測因子に関する検討. 日本消化器病学会雑誌(Web). 2025. 122
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