Art

J-GLOBAL ID：201802272242460216   Reference number：18A0947154

Measurement of plasma amyloid-β precursor protein APP770 concentration in healthy young volunteers: Preliminary study of APP770 as a potential biomarker for Alzheimer’s disease diagnosis.

健康な若いボランティアにおける血漿アミロイド-β前駆体蛋白質APP770濃度の測定:Alzheimer病診断のバイオマーカーとしての可能性を有するAPP770の予備的研究

Author (12)： Watanabe M. (Department of Rehabilitation Sciences, Faculty of Allied Health Sciences, Kansai University of Welfare Sciences) ,  Yamamoto M. (Department of Education, Faculty of Education, Kansai University of Welfare Sciences) ,  Hayasaki H. (Department of Rehabilitation Sciences, Faculty of Allied Health Sciences, Kansai University of Welfare Sciences) ,  Carvalho C.E. de (Department of Biology, University of Saskatchewan) ,  Nakamata E. (Department of Rehabilitation Sciences, Faculty of Allied Health Sciences, Kansai University of Welfare Sciences) ,  Nagino K. (Department of Rehabilitation Sciences, Faculty of Allied Health Sciences, Kansai University of Welfare Sciences) ,  Okamoto K. (Department of Rehabilitation Sciences, Faculty of Allied Health Sciences, Kansai University of Welfare Sciences) ,  Yuri Y. (Department of Rehabilitation Sciences, Faculty of Allied Health Sciences, Kansai University of Welfare Sciences) ,  Fujii Y. (Department of Rehabilitation Sciences, Faculty of Allied Health Sciences, Kansai University of Welfare Sciences) ,  Yurugi Y. (Department of Rehabilitation Sciences, Faculty of Allied Health Sciences, Kansai University of Welfare Sciences) ,  Shigemori K. (Department of Rehabilitation Sciences, Faculty of Allied Health Sciences, Kansai University of Welfare Sciences) ,  Watanabe K. (Medical Corporation Nissyoukai)
Material： 保健医療学雑誌(Web)  (Journal of Allied Health Sciences (Web))
Volume： 9  Issue： 1  Page： 6-11(J-STAGE)  Publication year： 2018 
JST Material Number： U0591A  ISSN： 2185-0399  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： ELISA ,...
Semi thesaurus term： *APP770 ,...

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Author keywords (3)： Alzheimer disease ,  APP770 ,  ELIZA

JST classification (3)： Basic neurology  (GN01020W) ,  Chemical examinations  (GC02020W) ,  Basic diagnostics  (GC03002P)

Reference (19)：

• 1 Selkoe DJ. Alzheimer's disease: Genes, proteins, and therapy. Physiol Rev 81: 741- 766, 2001.
• 2 Haass C, Selkoe DJ: Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's Amyloid β-peptide. Nature Rev, 8: 101-112, 2007.
• 3 O'Brien RJ, Wong PC: Amyloid precursor protein processing and Alzheimer's disease. Annu Rev Neurosci. 34:185-204, 2011.
• 4 Bayer TA, Cappai R, Masters CL et al.: It all sticks together - the APP-related family of proteins and Alzheimer's disease. Mol Psychiatry 4:524-528, 1999.
• 5 Wertkin AM, Turner RS, Pleasure SJ, Golde TE, Younkin SG, Trojanowski JQ, Lee VM: Human neurons derived from a teratocarcinoma cell line express solely the 695-amino acid Amyloid precursor protein and produce intracellular β-amyloid or A4 peptides. Proc Natl Acad Sci USA. 90:9513- 9517, 1993.

Terms in the title (10)： ボランティア ,  血漿 ,  アミロイド ,  前駆体 ,  蛋白質 ,  Alzheimer病 ,  診断 ,  バイオマーカー ,  可能性 ,  予備的研究