Art

J-GLOBAL ID：201802280241791674   Reference number：18A0256213

Deciphering antigen-responding antibody repertoires by using next-generation sequencing and confirming them through antibody-gene synthesis

次世代シークエンシングを用いたと抗体遺伝子合成によるその確認による抗原反応抗体レパートリーを解読する【Powered by NICT】

Author (9)： Kono Naoko (Center for Influenza Virus Research, National Institute of Infectious Diseases, Tokyo 162-8640, Japan) ,  Sun Lin (Graduate School of Life and Environmental Sciences, University of Tsukuba, Ibaraki 305-8572, Japan) ,  Toh Hiroyuki (School of Science and Technology, Kwansei Gakuin University, Hyogo 669-1337, Japan) ,  Shimizu Takeyuki (Department of Immunology, Kochi Medical School, Kochi University, Kochi 783-8505, Japan) ,  Xue Hanbing (Graduate School of Life and Environmental Sciences, University of Tsukuba, Ibaraki 305-8572, Japan) ,  Numata Osamu (Faculty of Life and Environmental Sciences, University of Tsukuba, Ibaraki 305-8572, Japan) ,  Ato Manabu (Department of Immunology, National Institute of Infectious Diseases, Tokyo 162-8640, Japan) ,  Ohnishi Kazuo (Department of Immunology, National Institute of Infectious Diseases, Tokyo 162-8640, Japan) ,  Itamura Shigeyuki (Center for Influenza Virus Research, National Institute of Infectious Diseases, Tokyo 162-8640, Japan)
Material： Biochemical and Biophysical Research Communications  (BBRC)
Volume： 487  Issue： 2  Page： 300-306  Publication year： 2017 
JST Material Number： B0118A  ISSN： 0006-291X  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Vast diversity and high specif...

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Thesaurus term： hapten ,  *immunoglobulin gene ,  immunoglobulin M ,  *antibody ,  antigen recognition ,  *antigen ,  ELISA ,  *immunoglobulin E ,  binding specificity ,  IgG1 ,  molecular mechanism ,  *next generation sequencing ,  Carrier Proteins ,  Adaptive Immunity ,  bioassay
Semi thesaurus term： 輸送蛋白質 ,  獲得免疫 ,  特異性 , 【Automatic Indexing@JST】

Author keywords (4)： Antibody repertoire ,  Next-generation sequencing ,  Antigen stimulation ,  Repertoire selection

JST classification (1)： Biochemistry of antigens,antibodies,complements  (ED04020L)

Terms in the title (5)： 次世代シークエンシング ,  抗体遺伝子 ,  抗原 ,  反応抗体 ,  解読