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J-GLOBAL ID：201902223699907341   Reference number：19A1493131

Cancer-secreted hsa-miR-940 induces an osteoblastic phenotype in the bone metastatic microenvironment via targeting ARHGAP1 and FAM134A

癌分泌HSA-miR-940はArhGAP1とFAM134aを標的とすることにより骨転移微小環境における骨芽細胞表現型を誘導する【JST・京大機械翻訳】

Author (16)： Hashimoto Kyoko (Department of Physiology and Cell Biology, Tokyo Medical and Dental University (TMDU), Graduate School, 113-8510 Tokyo, Japan) ,  Ochi Hiroki (Department of Physiology and Cell Biology, Tokyo Medical and Dental University (TMDU), Graduate School, 113-8510 Tokyo, Japan) ,  Sunamura Satoko (Department of Physiology and Cell Biology, Tokyo Medical and Dental University (TMDU), Graduate School, 113-8510 Tokyo, Japan) ,  Kosaka Nobuyoshi (Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, 104-0045 Tokyo, Japan) ,  Mabuchi Yo (Department of Biochemistry and Biophysics, Tokyo Medical and Dental University (TMDU), Graduate School, 113-8510 Tokyo, Japan) ,  Fukuda Toru (Department of Food Science, Tokyo Seiei College, 124-8530 Tokyo, Japan) ,  Yao Kenta (Department of Physiology and Cell Biology, Tokyo Medical and Dental University (TMDU), Graduate School, 113-8510 Tokyo, Japan) ,  Kanda Hiroaki (Department of Pathology, The Cancer Institute of the Japanese Foundation for Cancer Research, 135-8550 Tokyo, Japan) ,  Ae Keisuke (Department of Orthopaedic Oncology, Cancer Institute Ariake Hospital, 135-8550 Tokyo, Japan) ,  Okawa Atsushi (Department of Orthopaedic Surgery, Tokyo Medical and Dental University (TMDU), Graduate School, 113-8510 Tokyo, Japan) ,  Akazawa Chihiro (Department of Biochemistry and Biophysics, Tokyo Medical and Dental University (TMDU), Graduate School, 113-8510 Tokyo, Japan) ,  Ochiya Takahiro (Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, 104-0045 Tokyo, Japan) ,  Futakuchi Mitsuru (Department of Pathology, Nagasaki University Graduate School of Biomedical Sciences, 852-8523 Nagasaki, Japan) ,  Takeda Shu (Division of Endocrinology, Toranomon Hospital Endocrine Center, 105-8470 Tokyo, Japan) ,  Sato Shingo (Department of Physiology and Cell Biology, Tokyo Medical and Dental University (TMDU), Graduate School, 113-8510 Tokyo, Japan) ,  Sato Shingo (Department of Orthopaedic Surgery, Tokyo Medical and Dental University (TMDU), Graduate School, 113-8510 Tokyo, Japan)
Material： Proceedings of the National Academy of Sciences of the United States of America  (PNAS)
Volume： 115  Issue： 9  Page： 2204-2209  Publication year： 2018 
JST Material Number： D0387A  ISSN： 0027-8424  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： Bone metastatic lesions are cl...

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Thesaurus term： prostate gland ,  *secretion(physiology) ,  osteogenesis ,  osteoclast ,  tumor cell ,  *osteoblast ,  human(primates) ,  breast tumor ,  *phenotype
Semi thesaurus term： 過剰発現 ,  エキソソーム ,  マイクロRNA ,  病巣 ,  *微小環境 ,  *骨転移 , 【Automatic Indexing@JST】

Author keywords (5)： cancer-secreted microRNA ,  osteoblastic bone metastasis ,  exosome ,  prostate cancer ,  bone microenvironment

JST classification (2)： Skeletal system  (EJ10030R) ,  Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N)

Terms in the title (9)： 癌 ,  分泌 ,  HSA ,  標的 ,  骨転移 ,  微小環境 ,  骨芽細胞 ,  表現型 ,  誘導