Art

J-GLOBAL ID：201902231178160964   Reference number：19A0958970

Linagliptin Suppresses Electrical and Structural Remodeling in the Isoproterenol Induced Myocardial Injury Model

リナグリプチンはイソプロテレノール誘発心筋損傷モデルにおける電気的および構造的リモデリングを抑制する

Author (13)： Ishizue Naruya (Department of Cardiovascular Medicine, Kitasato University School of Medicine) ,  Niwano Shinichi (Department of Cardiovascular Medicine, Kitasato University School of Medicine) ,  Niwano Hiroe (Department of Cardiovascular Medicine, Kitasato University School of Medicine) ,  Oikawa Jun (Department of Cardiovascular Medicine, Kitasato University School of Medicine) ,  Nakamura Hironori (Department of Cardiovascular Medicine, Kitasato University School of Medicine) ,  Hashikata Takehiro (Department of Cardiovascular Medicine, Kitasato University School of Medicine) ,  Igarashi Tazuru (Department of Cardiovascular Medicine, Kitasato University School of Medicine) ,  Fujiishi Tamami (Department of Cardiovascular Medicine, Kitasato University School of Medicine) ,  Yoshizawa Tomoharu (Department of Cardiovascular Medicine, Kitasato University School of Medicine) ,  Kishihara Jun (Department of Cardiovascular Medicine, Kitasato University School of Medicine) ,  Satoh Akira (Department of Cardiovascular Medicine, Kitasato University School of Medicine) ,  Fukaya Hidehira (Department of Cardiovascular Medicine, Kitasato University School of Medicine) ,  Ako Junya (Department of Cardiovascular Medicine, Kitasato University School of Medicine)
Material： International Heart Journal (Web)
Volume： 60  Issue： 2  Page： 411-418(J-STAGE)  Publication year： 2019 
JST Material Number： U1357A  ISSN： 1349-3299  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *myocardial disease ,...
Semi thesaurus term： *DPP-IV inhibitor ,...

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Author keywords (1)： DPP-4 inhibitor

JST classification (2)： Basic medicine on cardiovascular system  (GJ01020K) ,  Basic research of cardioactive drugs  (GW07020N)

Substance index (2)： Isoproterenol ,  Linagliptin

Reference (29)：

• 1. Matsubara J, Sugiyama S, Akiyama E, et al. Dipeptidyl peptidase-4 inhibitor, sitagliptin, improves endothelial dysfunction in association with its anti-inflammatory effects in patients with coronary artery disease and uncontrolled diabetes. Circ J 2013; 77: 1337-44.
• 2. Nyström T, Gutniak MK, Zhang Q, et al. Effects of glucagon-like peptide-1 on endothelial function in type 2 diabetes patients with stable coronary artery disease. Am J Physiol Endocrinol Metab 2004; 287: E1209-15.
• 3. Sato A, Suzuki S, Watanabe S, et al. DPP4 inhibition ameliorates cardiac function by blocking the cleavage of HMGB1 in diabetic mice after myocardial infarction. Int Heart J 2017; 58: 778-86.
• 4. Inthachai T, Lekawanvijit S, Kumfu S, et al. Dipeptidyl peptidase-4 inhibitor improves cardiac function by attenuating adverse cardiac remodelling in rats with chronic myocardial infarction. Exp Physiol 2015; 100: 667-79.
• 5. Murase H, Kuno A, Miki T, et al. Inhibition of DPP-4 reduces acute mortality after myocardial infarction with restoration of autophagic response in type 2 diabetic rats. Cardiovasc Diabetol 2015; 14: 103.

Terms in the title (6)： リナグリプチン ,  イソプロテレノール ,  誘発 ,  心筋損傷 ,  モデル ,  リモデリング