Art

J-GLOBAL ID：201902246292465127   Reference number：19A1347275

Selective Cytotoxicity of Dihydroorotate Dehydrogenase Inhibitors to Human Cancer Cells Under Hypoxia and Nutrient-Deprived Conditions

低酸素および栄養欠乏条件下でのヒト癌細胞に対するジヒドロオロット酸デヒドロゲナーゼ阻害剤の選択的細胞毒性【JST・京大機械翻訳】

Author (17)： Miyazaki Yukiko (School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan) ,  Miyazaki Yukiko (Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan) ,  Inaoka Daniel K. (School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan) ,  Inaoka Daniel K. (Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan) ,  Inaoka Daniel K. (Department of Host-Defense Biochemistry, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki, Japan) ,  Shiba Tomoo (Department of Applied Biology, Graduate School of Science and Technology, Kyoto Institute of Technology, Kyoto, Japan) ,  Saimoto Hiroyuki (Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University, Tottori, Japan) ,  Sakura Takaya (School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan) ,  Amalia Eri (Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan) ,  Kido Yasutoshi (School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan) ,  Sakai Chika (Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan) ,  Nakamura Mari (Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan) ,  Moore Anthony L. (Biochemistry and Medicine, School of Life Sciences, University of Sussex, Brighton, United Kingdom) ,  Harada Shigeharu (Department of Applied Biology, Graduate School of Science and Technology, Kyoto Institute of Technology, Kyoto, Japan) ,  Kita Kiyoshi (School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan) ,  Kita Kiyoshi (Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan) ,  Kita Kiyoshi (Department of Host-Defense Biochemistry, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki, Japan)
Material： Frontiers in Pharmacology (Web)
Volume： 9  Page： 997  Publication year： 2018 
JST Material Number： U7091A  ISSN： 1663-9812  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： Human dihydroorotate dehydroge...

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Thesaurus term： culture(biology) ,  *dehydrogenase ,  *malnutrition ,  *tumor cell ,  ubiquinone ,  *cytotoxicity ,  binding site ,  *human(primates)
Semi thesaurus term： 微小環境 ,  天然化合物 ,  Acremonium ,  呼吸鎖 ,  生合成経路 ,  *阻害剤 , 【Automatic Indexing@JST】

Author keywords (8)： pyrimidine de novo biosynthesis ,  ubiquinone binding-site inhibitor ,  tumor bioenergetics ,  tumor microenvironment ,  structure-activity relationship ,  anticancer activity ,  ascofuranone ,  crystal structure

JST classification (3)： Cell physiology in general  (EF02010S) ,  Basic medicine on cardiovascular system  (GJ01020K) ,  Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N)

Substance index (1)： Dihydroorotic acid

Reference (74)：

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• Alberts B. (2014). Molecular Biology of the Cell. New York, NY: Garland Science. doi: 10.1002/1097-0142(19841001)54:7<1370::AID-CNCR2820540723>3.0.CO;2-5
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• Azeredo L. F. S. P., Coutinho J. P., Jabor V. A. P., Feliciano P. R., Nonato M. C., Kaiser C. R., et al (2017). Evaluation of 7-arylaminopyrazolo[1,5-a]pyrimidines as anti-Plasmodium falciparum, antimalarial, and Pf-dihydroorotate dehydrogenase inhibitors. Eur. J. Med. Chem. 126 72-83. doi: 10.1016/j.ejmech.2016.09.073
• Benucci M., Saviola G., Manfredi M., Sarzi-Puttini P., Atzeni F. (2011). Cost effectiveness analysis of disease-modifying antirheumatic drugs in rheumatoid arthritis. A systematic review literature. Int. J. Rheumatol. 2011:845496. doi: 10.1155/2011/845496

Terms in the title (8)： 低酸素 ,  栄養欠乏 ,  ヒト ,  癌細胞 ,  ジヒドロオロット酸 ,  デヒドロゲナーゼ ,  阻害剤 ,  細胞毒性