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J-GLOBAL ID：201902255439526344   Reference number：19A1110597

Effect of Metallothionein-III on Mercury-Induced Chemokine Gene Expression

水銀誘発ケモカイン遺伝子発現に及ぼすメタロチオネインIIIの影響【JST・京大機械翻訳】

Author (10)： Lee Jin-Yong (Laboratory of Pharmaceutical Health Sciences, School of Pharmacy, Aichi Gakuin University, 1-100 Kusumoto-cho, Chikusa-ku, Nagoya 464-8650, Japan) ,  Tokumoto Maki (Laboratory of Pharmaceutical Health Sciences, School of Pharmacy, Aichi Gakuin University, 1-100 Kusumoto-cho, Chikusa-ku, Nagoya 464-8650, Japan) ,  Hwang Gi-Wook (Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan) ,  Kim Min-Seok (Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan) ,  Kim Min-Seok (Laboratory Animal Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu 41061, Korea) ,  Takahashi Tsutomu (Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan) ,  Takahashi Tsutomu (Department of Environmental Health, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1, Horinouchi, Hachioji, Tokyo 192-0392, Japan) ,  Naganuma Akira (Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan) ,  Yoshida Minoru (Faculty of Health and Medical Care, Hachinohe Gakuin University, 3-98 Mihono, Hachinohe 031-8588, Japan) ,  Satoh Masahiko (Laboratory of Pharmaceutical Health Sciences, School of Pharmacy, Aichi Gakuin University, 1-100 Kusumoto-cho, Chikusa-ku, Nagoya 464-8650, Japan)
Material： Toxics (Web)
Volume： 6  Issue： 3  Page： 48  Publication year： 2018 
JST Material Number： U7285A  ISSN： 2305-6304  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： Mercury compounds are known to...

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Thesaurus term： Cerebellum ,  mercury compound ,  *gene ,  *mercury (element) ,  *Metallothionein ,  *chemokine ,  brain disease ,  *gene expression ,  Brain tissue ,  Mercury vapor ,  Cerebrum ,  wild-type mouse ,  molecular mechanism ,  *Metallothionein 3 ,  Brain ,  *molecular genetic phenomenon ,  organomercury compound

Author keywords (4)： methylmercury ,  mercury vapor ,  metallothionein-III ,  chemokine

JST classification (5)： Cardiovascular system diseases  (GJ03000C) ,  Cell physiology in general  (EF02010S) ,  Basic medicine on cardiovascular system  (GJ01020K) ,  Clinical medicine on cardiovascular system in general  (GJ01030V) ,  Toxicity of metals and metal compounds  (GZ02022V)

Substance index (1)： Methylmercury

Reference (37)：

• Lee, J.Y.; Ishida, Y.; Kuge, S.; Naganuma, A.; Hwang, G.W. Identification of substrates of F-box protein involved in methylmercury toxicity in yeast cells. FEBS Lett. 2015, 589, 2720-2725.
• Lee, J.Y.; Ishida, Y.; Takahashi, T.; Naganuma, A.; Hwang, G.W. Transport of pyruvate into mitochondria is involved in methylmercury toxicity. Sci. Rep. 2016, 6, 21528.
• Tokumoto, M.; Lee, J.Y.; Shimada, A.; Tohyama, C.; Satoh, M. Glutathione has a more important role than metallothionein-I/II against inorganic mercury-induced acute renal toxicity. J. Toxicol. Sci. 2018, 43, 275-280.
• Mori, N.; Yasutake, A.; Marumoto, M.; Hirayama, K. Methylmercury inhibits electron transport chain activity and induces cytochrome c release in cerebellum mitochondria. J. Toxicol. Sci. 2011, 36, 253-259.
• Watanabe, J.; Nakamachi, T.; Ogawa, T.; Naganuma, A.; Nakamura, M.; Shioda, S.; Nakajo, S. Characterization of antioxidant protection of cultured neural progenitor cells (NPC) against methylmercury (MeHg) toxicity. J. Toxicol. Sci. 2009, 34, 315-325.

Terms in the title (5)： 水銀 ,  誘発 ,  ケモカイン ,  遺伝子発現 ,  メタロチオネインIII