Art

J-GLOBAL ID：201902259316842463   Reference number：19A0601497

Phase II trial of aflibercept with FOLFIRI as a second-line treatment for Japanese patients with metastatic colorectal cancer

転移性結腸直腸癌の日本人患者に対する二次治療としてのFOLFIRIを用いたアフリベルセプトの第II相試験

Author (23)： Denda Tadamichi (Department of Gastroenterology, Chiba Cancer Center, Chiba, Japan) ,  Sakai Daisuke (Department of Frontier Science for Cancer and Chemotherapy, Osaka University Graduate School of Medicine, Suita, Japan) ,  Hamaguchi Tetsuya (Department of Gastrointestinal Medical Oncology, National Cancer Center Hospital, Tokyo, Japan) ,  Sugimoto Naotoshi (Department of Medical Oncology, Osaka Medical Center for Cancer and Cardiovascular Disease, Osaka, Japan) ,  Ura Takashi (Department of Clinical Oncology, Aichi Cancer Center Hospital, Nagoya, Japan) ,  Yamazaki Kentaro (Department of Gastrointestinal Oncology, Shizuoka Cancer Center, Shizuoka, Japan) ,  Fujii Hirofumi (Department of Clinical Oncology, Jichi Medical University Hospital, Shimotsuke, Japan) ,  Kajiwara Takeshi (Department of Gastrointestinal Medical Oncology, Shikoku Cancer Center, Matsuyama, Japan) ,  Nakajima Takako Eguchi (Department of Medical Oncology, St. Marianna University School of Medical Hospital, Kawasaki, Japan) ,  Takahashi Shin (Department of Medical Oncology, Tohoku University Hospital, Sendai, Japan) ,  Otsu Satoshi (Department of Medical Oncology, Oita University Hospital, Yufu, Japan) ,  Komatsu Yoshito (Department of Cancer Center, Hokkaido University Hospital, Sapporo, Japan) ,  Nagashima Fumio (Department of Medical Oncology, Kyorin University Hospital, Mitaka, Japan) ,  Moriwaki Toshikazu (Department of Gastroenterology, University of Tsukuba Hospital, Tsukuba, Japan) ,  Esaki Taito (Department of Gastrointestinal and Medical Oncology, National Kyushu Cancer Center, Fukuoka, Japan) ,  Sato Takeo (Department of Gastrointestinal Surgery, Kitasato University East Hospital, Sagamihara, Japan) ,  Itabashi Michio (Department of Surgery 2, Tokyo Women’s Medical University Hospital, Tokyo, Japan) ,  Oki Eiji (Department of Gastrointestinal Surgery, Kyushu University Hospital, Fukuoka, Japan) ,  Sasaki Toru (Local Medical Operation, Sanofi K. K., Tokyo, Japan) ,  Sunaga Yoshinori (Biostatstics& Programming, Sanofi K. K., Tokyo, Japan) ,  Ziti-Ljajic Samira (Pharmacokinetics, Sanofi Oncology, Alfortville, France) ,  Brillac Claire (Modeling& Simulation, Sanofi Oncology, Alfortville, France) ,  Yoshino Takayuki (Department of Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan)
Material： Cancer Science (Web)  (Cancer Sci (Web))
Volume： 110  Issue： 3  Page： 1032-1043  Publication year： 2019 
JST Material Number： U0505A  ISSN： 1349-7006  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *drug therapy ,...
Semi thesaurus term： *FOLFIRI therapy ,...

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Author keywords (5)： aflibercept ,  angiogenesis inhibitors ,  colorectal neoplasms ,  neoplasm metastasis ,  vascular endothelial growth factor A

JST classification (1)： Clinical application of antitumor(=antineoplastic)drugs  (GW16020L)

Substance index (3)： Fluorouracil ,  Levofolinate calcium ,  CPT-11

Terms in the title (7)： 転移性結腸直腸癌 ,  日本人 ,  患者 ,  二次治療 ,  FOLFIRI ,  アフリベルセプト ,  第II相試験