Art

J-GLOBAL ID：201902269152804303   Reference number：19A2659128

Thrombospondin 1-mediated suppression of mast cell degranulation is involved in the efficacy of sublingual immunotherapy

肥満細胞脱顆粒のトロンボスポンジン1仲介抑制は舌下免疫療法の有効性に関与する

Author (17)： Kaminuma Osamu (Allergy and Immunology Project, The Tokyo Metropolitan Institute of Medical Science) ,  Kaminuma Osamu (Center for Life Science Research, University of Yamanashi) ,  Kaminuma Osamu (Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital) ,  Kitamura Noriko (Allergy and Immunology Project, The Tokyo Metropolitan Institute of Medical Science) ,  Gotoh Minoru (Allergy and Immunology Project, The Tokyo Metropolitan Institute of Medical Science) ,  Gotoh Minoru (Department of Otorhinolaryngology, Nippon Medical School) ,  Shindo Mayumi (Center for Basic Technology Research, The Tokyo Metropolitan Institute of Medical Science) ,  Watanabe Nobumasa (Allergy and Immunology Project, The Tokyo Metropolitan Institute of Medical Science) ,  Saeki Mayumi (Allergy and Immunology Project, The Tokyo Metropolitan Institute of Medical Science) ,  Nishimura Tomoe (Allergy and Immunology Project, The Tokyo Metropolitan Institute of Medical Science) ,  Mori Akio (Allergy and Immunology Project, The Tokyo Metropolitan Institute of Medical Science) ,  Mori Akio (Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital) ,  Nemoto Soichi (The Department of Obstetrics and Gynecology, National Hospital Organization, Sagamihara National Hospital) ,  Tatsumi Hideki (The Department of Obstetrics and Gynecology, National Hospital Organization, Sagamihara National Hospital) ,  Okubo Kimihiro (Allergy and Immunology Project, The Tokyo Metropolitan Institute of Medical Science) ,  Okubo Kimihiro (Department of Otorhinolaryngology, Nippon Medical School) ,  Hiroi Takachika (Allergy and Immunology Project, The Tokyo Metropolitan Institute of Medical Science)
Material： Allergology International  (Allergol Int)
Volume： 68  Issue： Supplement.1  Page： S9-S10(J-STAGE)  Publication year： 2019 
JST Material Number： L6446A  ISSN： 1323-8930  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： effectiveness ,...
Semi thesaurus term： *Thrombospondin 1 ,...

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JST classification (1)： Immunologic diseases,allergic diseases in general.  (GD04010C)

Reference (10)：

• 1. Mitobe Y, Yokomoto Y, Ohashi-Doi K. Safety evaluation of standardized allergen extract of Japanese cedar pollen for sublingual immunotherapy. Regul Toxicol Pharmacol 2015;71:529-40.
• 2. Ihara F, Sakurai D, Yonekura S, Iinuma T, Yagi R, Sakurai T, et al. Identification of specifically reduced Th2 cell subsets in allergic rhinitis patients after sublingual immunotherapy. Allergy 2018;73:1823-32.
• 3. Tofukuji S, Katayama K, Nakano Y, Ishida S, Tsuchida J, Tajiri M, et al. Allergen-specific sublingual immunotherapy is dose- and duration-dependent in a murine allergic rhinitis model. J Allergy Clin Immunol 2018;142:1977-9.
• 4. Gotoh M, Kaminuma O, Nakaya A, Katayama K, Watanabe N, Saeki M, et al. Involvement of taste receptors in the effectiveness of sublingual immunotherapy. Allergol Int 2018;67:421-4.
• 5. Gotoh M, Kaminuma O, Hiroi T, Okubo K. Microarray-based multivariate analysis of the effectiveness of sublingual immunotherapy for cedar pollinosis. Allergy Asthma Immunol Res 2018;10:562-9.

Terms in the title (6)： 肥満細胞 ,  脱顆粒 ,  トロンボスポンジン1 ,  仲介 ,  舌下免疫療法 ,  有効性