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J-GLOBAL ID：202002210976784335   Reference number：20A2336688

Design, Synthesis, and Biological Activity of Conformationally Restricted Analogues of Silibinin

シリビニンの立体配座制限類似体の設計,合成および生物活性【JST・京大機械翻訳】

Author (9)： Mizuno Mirei (Division of Organic and Medicinal Chemistry, School of Pharmacy, Showa University, Japan) ,  Mori Kazunori (Division of Cancer Cell Biology, School of Pharmacy, Showa University, Japan) ,  Tsuchiya Keisuke (Division of Organic and Medicinal Chemistry, School of Pharmacy, Showa University, Japan) ,  Tsuchiya Keisuke (Division of Organic Chemistry, National Institute of Health Sciences, Kanagawa, Japan) ,  Takaki Takashi (Division of Electron Microscopy, Showa University, Japan) ,  Misawa Takashi (Division of Organic Chemistry, National Institute of Health Sciences, Kanagawa, Japan) ,  Demizu Yosuke (Division of Organic Chemistry, National Institute of Health Sciences, Kanagawa, Japan) ,  Shibanuma Motoko (Division of Cancer Cell Biology, School of Pharmacy, Showa University, Japan) ,  Fukuhara Kiyoshi (Division of Organic and Medicinal Chemistry, School of Pharmacy, Showa University, Japan)
Material： ACS Omega
Volume： 5  Issue： 36  Page： 23164-23174  Publication year： 2020 
JST Material Number： W5044A  ISSN： 2470-1343  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： Silibinin (Sib), one of the ma...

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Thesaurus term： geometry ,  aggregation ,  *steric conformation ,  Diabetes Mellitus ,  flexibility ,  Cell Proliferation ,  *biological activity ,  Alzheimer Disease ,  alpha-glucosidase ,  amyloid beta-protein ,  educt ,  lead compound ,  antioxidant activity ,  Amyloid ,  glycoprotein ,  animal protein ,  oxygen heterocyclic compound ,  polyphenol ,  flavonoid ,  polynuclear aromatic compound ,  polyol

JST classification (4)： Food chemistry,nutritional value  (FJ01020J) ,  Metabolic diseases,nutritional diseases in general.  (GD05010J) ,  Metabolism and nutrition of sugar(=glucide)  (EJ02035H) ,  Basic research of pharmacology of crude drugs  (GX06020J)

Substance index (2)： (-)-Epicatechin ,  Catechin

Terms in the title (6)： シリビニン ,  立体配座 ,  制限 ,  類似体 ,  設計 ,  生物活性