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J-GLOBAL ID：202002233886530013   Reference number：20A0559465

Carvacrol inhibits the neuronal voltage-gated sodium channels Na_v1.2, Na_v1.6, Na_v1.3, Na_v1.7, and Na_v1.8 expressed in Xenopus oocytes with different potencies

カルバクロールは,アフリカツメガエル卵母細胞で発現されるニューロン電位依存性ナトリウムチャンネルNa_v1.2,Na_v1.6,Na_v1.3,Na_v1.7およびNa_v1.8を異なる効力で阻害する

Author (10)： Horishita Takafumi (Department of Anesthesiology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan) ,  Ogata Yuichi (Department of Anesthesiology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan) ,  Horishita Reiko (Department of Anesthesiology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan) ,  Fukui Ryo (Department of Anesthesiology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan) ,  Moriwaki Kuniaki (Department of Anesthesiology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan) ,  Ueno Susumu (Department of Occupational Toxicology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Kitakyushu, Japan) ,  Yanagihara Nobuyuki (Laboratory of Pharmacology, Faculty of Food and Nutrition, Kyushu Nutrition Welfare University, Kitakyushu, Japan) ,  Uezono Yasuhito (Cancer Pathophysiology Division, National Cancer Center Research Institute, Tokyo, Japan) ,  Sudo Yuka (Department of Molecular Pathology & Metabolic Disease, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan) ,  Minami Kouichiro (Emergency Life-Saving Technique Academy of Tokyo, Tokyo, Japan)
Material： Journal of Pharmacological Sciences (Web)  (J Pharmacol Sci (Web))
Volume： 142  Issue： 4  Page： 140-147  Publication year： 2020 
JST Material Number： U0667A  ISSN： 1347-8613  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： *essential oil ,...
Semi thesaurus term： NAV1.2 Voltage-Gated Sodium Channel ,...

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Author keywords (5)： Carvacrol ,  Voltage-gated sodium channels ,  Analgesic mechanism ,  Analgesic effect ,  More potent inhibitory effects toward Na_v1.2 and Na_v1.6

JST classification (2)： Basic research of antipyretic analgesics  (GW03040H) ,  Receptors on cell membrane  (EF04030C)

Substance index (1)： Carvacrol

Terms in the title (6)： カルバクロール ,  アフリカツメガエル卵母細胞 ,  発現 ,  ニューロン ,  電位依存性ナトリウムチャンネル ,  阻害