Art

J-GLOBAL ID：202002237343033404   Reference number：20A0539207

Dasatinib can Impair Left Ventricular Mechanical Function But May Lack Proarrhythmic Effect: A Proposal of Non-clinical Guidance for Predicting Clinical Cardiovascular Adverse Events of Tyrosine Kinase Inhibitors

ダサチニブは左心室の機械的機能を損なうが,前不整脈効果を欠く可能性がある:チロシンキナーゼ阻害剤の臨床的心血管有害事象を予測するための非臨床ガイダンスの提案【JST・京大機械翻訳】

Author (15)： Izumi-Nakaseko Hiroko (Department of Pharmacology, Faculty of Medicine, Toho University, Tokyo, Japan) ,  Izumi-Nakaseko Hiroko (Department of Pharmacology, Toho University Graduate School of Medicine, Tokyo, Japan) ,  Fujiyoshi Masachika (Personalized Medicine & Preventive Healthcare Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan) ,  Hagiwara-Nagasawa Mihoko (Department of Pharmacology, Faculty of Medicine, Toho University, Tokyo, Japan) ,  Goto Ai (Department of Pharmacology, Toho University Graduate School of Medicine, Tokyo, Japan) ,  Chiba Koki (Department of Pharmacology, Toho University Graduate School of Medicine, Tokyo, Japan) ,  Kambayashi Ryuichi (Department of Pharmacology, Faculty of Medicine, Toho University, Tokyo, Japan) ,  Naito Atsuhiko T. (Department of Pharmacology, Faculty of Medicine, Toho University, Tokyo, Japan) ,  Naito Atsuhiko T. (Department of Pharmacology, Toho University Graduate School of Medicine, Tokyo, Japan) ,  Ando Kentaro (Department of Pharmacology, Faculty of Pharmacy, Chiba Institute of Science, Choshi, Chiba, Japan) ,  Kanda Yasunari (Division of Pharmacology, National Institute of Health Sciences, Kawasaki, Kanagawa, Japan) ,  Ishii Itsuko (Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan) ,  Ishii Itsuko (Division of Pharmacy, Chiba University Hospital, Chiba, Japan) ,  Sugiyama Atsushi (Department of Pharmacology, Faculty of Medicine, Toho University, Tokyo, Japan) ,  Sugiyama Atsushi (Department of Pharmacology, Toho University Graduate School of Medicine, Tokyo, Japan)
Material： Cardiovascular Toxicology
Volume： 20  Issue： 1  Page： 58-70  Publication year： 2020 
JST Material Number： W4139A  ISSN： 1559-0259  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Abstract/Point： Abstract: Tyrosine kinase inhi...

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Thesaurus term： in vitro experiment ,  plasma concentration ,  Heart ,  pluripotent stem cell ,  *heart ventricle ,  intravenous administration ,  Plasma ,  *arrhythmia ,  Apoptosis ,  Cardiac Myocyte ,  human ,  cytotoxicity ,  Anesthesia ,  heartbeat ,  Pharmacology

Author keywords (4)： Dasatinib ,  Halothane-anesthetized dogs ,  Human induced pluripotent stem cell-derived cardiomyocytes ,  Safety pharmacology

JST classification (2)： Basic medicine on cardiovascular system  (GJ01020K) ,  Clinical application of antitumor(=antineoplastic)drugs  (GW16020L)

Terms in the title (11)： ダサチニブ ,  左心室 ,  不整脈 ,  可能性 ,  チロシンキナーゼ阻害剤 ,  臨床 ,  心血管 ,  有害事象 ,  予測 ,  ガイダンス ,  提案