Art

J-GLOBAL ID：202002255083631697   Reference number：20A1917273

Dimethyl fumarate prevents osteoclastogenesis by decreasing NFATc1 expression, inhibiting of erk and p38 MAPK phosphorylation, and suppressing of HMGB1 release

フマル酸ジメチルはNFATc1発現の減少,erkおよびp38 MAPKリン酸化の阻害およびHMGB1放出の抑制により破骨細胞形成を予防する【JST・京大機械翻訳】

Author (6)： Nishioku Tsuyoshi (Department of Pharmacology, Faculty of Pharmaceutical Sciences, Nagasaki International University, 2825-7 Huis Ten Bosch, Sasebo, Nagasaki, 859-3298, Japan) ,  Kawamoto Momomi (Department of Pharmacology, Faculty of Pharmaceutical Sciences, Nagasaki International University, 2825-7 Huis Ten Bosch, Sasebo, Nagasaki, 859-3298, Japan) ,  Okizono Ryuya (Department of Pharmacology, Faculty of Pharmaceutical Sciences, Nagasaki International University, 2825-7 Huis Ten Bosch, Sasebo, Nagasaki, 859-3298, Japan) ,  Sakai Eiko (Division of Oral Pharmacology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8588, Japan) ,  Okamoto Kuniaki (Department of Dental Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1, Shikata-cho, Kita-ku, Okayama, 700-8525, Japan) ,  Tsukuba Takayuki (Division of Oral Pharmacology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8588, Japan)
Material： Biochemical and Biophysical Research Communications  (BBRC)
Volume： 530  Issue： 2  Page： 455-461  Publication year： 2020 
JST Material Number： B0118A  ISSN： 0006-291X  Document type： Article
Article type： 短報  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Osteoclasts are multinucleated...

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Thesaurus term： gene ,  differentiation (biology) ,  *phosphorylation ,  macrophage ,  Bone Resorption ,  monocyte ,  *osteoclast ,  osteoporosis ,  Up-Regulation ,  transcription factor ,  rheumatoid arthritis ,  ERK ,  *P38 ,  *osteoclast cell formation ,  NF-E2-Related Factor 2

Author keywords (6)： Osteoclast ,  Dimethyl fumarate ,  Nuclear factor of activated T cells c1 ,  Extracellular signal-regulated kinase ,  p38 mitogen activated protein kinase ,  High mobility group box 1

JST classification (2)： Function of cell components  (EF03060C) ,  Cell physiology in general  (EF02010S)

Terms in the title (12)： フマル酸ジメチル ,  NFATc1 ,  発現 ,  ERK ,  P38 ,  MAPK ,  リン酸化 ,  阻害 ,  HMGB1 ,  放出 ,  破骨細胞形成 ,  予防