Art

J-GLOBAL ID：202002256019461213   Reference number：20A1182015

A designer molecular chaperone against transmissible spongiform encephalopathy slows disease progression in mice and macaques

伝染性海綿状脳症に対するデザイナー分子シャペロンはマウスおよびマカクにおける疾患進行を遅延させる【JST・京大機械翻訳】

Author (30)： Yamaguchi Keiichi (Center for Emerging Infectious Diseases, Gifu University, Gifu, Japan) ,  Yamaguchi Keiichi (United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Gifu, Japan) ,  Yamaguchi Keiichi (Institute for Protein Research, Osaka University, Osaka, Japan) ,  Kamatari Yuji O. (Center for Emerging Infectious Diseases, Gifu University, Gifu, Japan) ,  Kamatari Yuji O. (Life Science Research Center, Gifu University, Gifu, Japan) ,  Ono Fumiko (Faculty of Animal Crisis Management, Chiba Institute of Science, Choshi, Japan) ,  Ono Fumiko (Faculty of Veterinary Medicine, Okayama University of Science, Imabari, Japan) ,  Shibata Hiroaki (Tsukuba Primate Research Center, National Institutes of Biomedical Innovation, Health and Nutrition, Tsukuba, Japan) ,  Shibata Hiroaki (Center for Development of Advanced Medical Technology, Jichi Medical University, Shimotsuke, Japan) ,  Fuse Takayuki (Department of Molecular Microbiology and Immunology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan) ,  Elhelaly Abdelazim Elsayed (Center for Emerging Infectious Diseases, Gifu University, Gifu, Japan) ,  Elhelaly Abdelazim Elsayed (United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Gifu, Japan) ,  Elhelaly Abdelazim Elsayed (Department of Food Hygiene and Control, Faculty of Veterinary Medicine, Suez Canal University, Ismalia, Egypt) ,  Fukuoka Mayuko (Center for Emerging Infectious Diseases, Gifu University, Gifu, Japan) ,  Fukuoka Mayuko (United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Gifu, Japan) ,  Kimura Tsutomu (Center for Emerging Infectious Diseases, Gifu University, Gifu, Japan) ,  Kimura Tsutomu (Department of Chemistry, Faulty of Science Division II, Tokyo University of Science, Tokyo, Japan) ,  Hosokawa-Muto Junji (Center for Emerging Infectious Diseases, Gifu University, Gifu, Japan) ,  Hosokawa-Muto Junji (First Department of Forsenic Science, National Research Institute of Police Science, Kashiwa, Japan) ,  Ishikawa Takeshi (Center for Emerging Infectious Diseases, Gifu University, Gifu, Japan) ,  Ishikawa Takeshi (Department of Molecular Microbiology and Immunology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan) ,  Ishikawa Takeshi (Graduate School of Science and Engineering, Kagoshima University, Kagoshima, Japan) ,  Tobiume Minoru (Department of Pathology, National Institute of Infectious Disease, Tokyo, Japan) ,  Takeuchi Yoshinori (Department of Biostatistics, School of Public Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan) ,  Matsuyama Yutaka (Department of Biostatistics, School of Public Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan) ,  Ishibashi Daisuke (Department of Molecular Microbiology and Immunology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan) ,  Nishida Noriyuki (Department of Molecular Microbiology and Immunology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan) ,  Kuwata Kazuo (Center for Emerging Infectious Diseases, Gifu University, Gifu, Japan) ,  Kuwata Kazuo (United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Gifu, Japan) ,  Kuwata Kazuo (Department of Gene and Development, Graduate School of Medicine, Gifu University, Gifu, Japan)
Material： Nature Biomedical Engineering
Volume： 3  Issue： 3  Page： 206-219  Publication year： 2019 
JST Material Number： W4772A  ISSN： 2157-846X  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Abstract/Point： Abstract: Transmissible spongi...

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Thesaurus term： NMR ,  interaction ,  computer simulation ,  cerebrospinal fluid ,  intraperitoneal administration ,  drug resistance ,  *Macaca ,  in vitro experiment ,  *chaperone protein ,  prion ,  biomarker ,  prion disease ,  aggregate
Semi thesaurus term： 神経変性疾患 ,  *疾患進行 ,  分子動力学シミュレーション , 【Automatic Indexing@JST】

JST classification (4)： Basic research of drugs acting on other pathogenic organisms  (GW17100F) ,  Structure-activity relationship of drugs  (GV01050B) ,  Basic neurology  (GN01020W) ,  Molecular structure  (EB03020Y)

Terms in the title (7)： 伝染性海綿状脳症 ,  デザイナー ,  分子シャペロン ,  マウス ,  マカク ,  疾患進行 ,  遅延