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J-GLOBAL ID：202002262606554110   Reference number：20A1532019

Nuclear factor erythroid 2-related factor 2 (NRF2) is a negative regulator of tissue plasminogen activator synthesis in cultured human vascular endothelial EA.hy926 cells

NF-E2関連因子2(NRF2)は培養ヒト血管内皮EA.hy926細胞における組織プラスミノーゲン活性化因子合成の負の調節因子である

Author (8)： Takahashi Tsutomu (Department of Environmental Health, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences) ,  Nakano Tsuyoshi (Department of Environmental Health, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences) ,  Katoh Go (Department of Environmental Health, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences) ,  Shinoda Yo (Department of Environmental Health, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences) ,  Yamamoto Chika (Department of Environmental Health, Faculty of Pharmaceutical Sciences, Toho University) ,  Yoshida Eiko (Department of Environmental Health, Faculty of Pharmaceutical Sciences, Tokyo University of Science) ,  Kaji Toshiyuki (Department of Environmental Health, Faculty of Pharmaceutical Sciences, Tokyo University of Science) ,  Fujiwara Yasuyuki (Department of Environmental Health, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences)
Material： Journal of Toxicological Sciences  (J Toxicol Sci)
Volume： 45  Issue： 4  Page： 237-243(J-STAGE)  Publication year： 2020 
JST Material Number： Z0265B  ISSN： 0388-1350  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： human(primates) ,...
Semi thesaurus term： EAhy926 cell ,...

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Author keywords (5)： NRF2 ,  Plasminogen activator ,  Fibrinolysis ,  Human endothelial cell line EA.hy926 ,  Vascular

JST classification (2)： Basic hematology  (GK01020N) ,  Basic medicine on cardiovascular system  (GJ01020K)

Substance index (1)： Sulforaphane

Reference (30)：

• Collen, D. (2001): Ham-Wasserman lecture: role of the plasminogen system in fibrin-homeostasis and tissue remodeling. Hematology (Am. Soc. Hematol. Educ. Program), 2001, 1-9.
• Francis, R.B. Jr. and Neely, S. (1989): Inhibition of endothelial secretion of tissue-type plasminogen activator and its rapid inhibitor by agents which increase intracellular cyclic AMP. Biochim. Biophys. Acta, 1012, 207-213.
• Fujie, T., Murakami, M., Yoshida, E., Tachinami, T., Shinkai, Y., Fujiwara, Y., Yamamoto, C., Kumagai, Y., Naka, H. and Kaji, T. (2016): Copper diethyldithiocarbamate as an activator of Nrf2 in cultured vascular endothelial cells. J. Biol. Inorg. Chem., 21, 263-273.
• Fujie, T., Okino, S., Yoshida, E., Yamamoto, C., Naka, H. and Kaji, T. (2017): Copper diethyldithiocarbamate as an inhibitor of tissue plasminogen activator synthesis in cultured human coronary endothelial cells. J. Toxicol. Sci., 42, 553-558.
• Gelehrter, T.D. and Sznycer-Laszuk, R. (1986): Thrombin induction of plasminogen activator-inhibitor in cultured human endothelial cells. J. Clin. Invest., 77, 165-169.

Terms in the title (8)： NF-E2関連因子2 ,  NRF2 ,  培養 ,  ヒト ,  血管内皮 ,  細胞 ,  組織プラスミノーゲン活性化因子 ,  調節因子