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J-GLOBAL ID：202201001430248445   Update date: Aug. 11, 2024

Hayashi Yuki

ハヤシ ユウキ | Hayashi Yuki
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Research field  (1)： Functional biochemistry
Research keywords  (9)： protein quality control ,  ER stress ,  autophagy ,  ERAD ,  ER-phagy ,  membrane protein ,  ALS ,  タンパク質凝集 ,  ubiquitin
Research theme for competitive and other funds  (4)：
  • 2023 - 2025 小胞体における不良膜タンパク質のリソソーム分解機構の包括的理解と創薬基盤の確立
  • 2022 - 2024 Analysis of a novel membrane protein quality system mediated by selective lysosomal degradation
  • 2021 - 2023 Identification of genes involved in the lysosomal degradation of aberrant membrane proteins at the endoplasmic reticulum
  • 2017 - 2020 Analysis of the effect of ALS-linked SOD1 mutants on ERAD complex and its function
Papers (6)：
  • Riko Tabuchi, Yurika Momozawa, Yuki Hayashi, Hisashi Noma, Hidenori Ichijo, Takao Fujisawa. SoDCoD: a comprehensive database of Cu/Zn superoxide dismutase conformational diversity caused by ALS-linked gene mutations and other perturbations. Database. 2024. 2024
  • Yuki Hayashi, Hidenori Ichijo. Massive ER protein disposal by reticulophagy receptors and selective disposal by TOLLIP. Autophagy. 2024
  • Yuki Hayashi, Sho Takatori, Waleed Y Warsame, Taisuke Tomita, Takao Fujisawa, Hidenori Ichijo. TOLLIP acts as a cargo adaptor to promote lysosomal degradation of aberrant ER membrane proteins. The EMBO journal. 2023. e114272
  • Jasmin Schulz, Dönem Avci, Markus A. Queisser, Aljona Gutschmidt, Lena-Sophie Dreher, Emma J. Fenech, Norbert Volkmar, Yuki Hayashi, Thorsten Hoppe, John C. Christianson. Conserved cytoplasmic domains promote Hrd1 ubiquitin ligase complex formation for ER-associated degradation (ERAD). Journal of Cell Science. 2017. 130. 19. 3322-3335
  • Takao Fujisawa, Motoo Takahashi, Yuka Tsukamoto, Namiko Yamaguchi, Masayoshi Nakoji, Megumi Endo, Hiroshi Kodaira, Yuki Hayashi, Hideki Nishitoh, Isao Naguro, et al. The ASK1-specific inhibitors K811 and K812 prolong survival in a mouse model of amyotrophic lateral sclerosis. Human Molecular Genetics. 2016. 25. 2. 245-253
ｍore...
Education (3)：
  • 2017 - 2020 The University of Tokyo Graduate School of Pharmaceutical Sciences
  • 2015 - 2017 The University of Tokyo Graduate School of Pharmaceutical Sciences
  • 2011 - 2015 The University of Tokyo Faculty of Pharmaceutical Sciences
Professional career (1)：
  • Pharmaceutical Sciences (The University of Tokyo)
Work history (3)：
  • 2024/04 - 現在 The University of Tokyo Graduate School of Medicine Project Researcher
  • 2020/04 - 2024/03 The University of Tokyo Graduate School of Pharmaceutical Sciences Project Researcher
  • 2017/04 - 2020/03 Japan Society for the Promotion of Science Research fellowship for young scientists
Association Membership(s) (2)：
日本生化学会 ,  日本分子生物学会
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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