Study on excitation contraction coupling of skeletal muscle
Contribution of Sarcoplasmic reticulum in Cardiac and Skeletal muscles.
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論文 (126件)：
Takashi Murayama, Yuya Otori, Nagomi Kurebayashi, Toshiko Yamazawa, Hideto Oyamada, Takashi Sakurai, Haruo Ogawa. Dual role of the S5 segment in type 1 ryanodine receptor channel gating. Communications Biology. 2024. 7. 1
Yuta Okabe, Nobuyuki Murakoshi, Nagomi Kurebayashi, Hana Inoue, Yoko Ito, Takashi Murayama, Chika Miyoshi, Hiromasa Funato, Koichiro Ishii, Dongzhu Xu, et al. An inherited life-threatening arrhythmia model established by screening randomly mutagenized mice. Proceedings of the National Academy of Sciences of the United States of America. 2024. 121. 17. e2218204121
Ryosuke Ishida, Xi Zeng, Nagomi Kurebayashi, Takashi Murayama, Shuichi Mori, Hiroyuki Kagechika. Discovery and Structure-Activity Relationship of a Ryanodine Receptor 2 Inhibitor. Chemical & pharmaceutical bulletin. 2024. 72. 4. 399-407
Ryosuke Ishida, Nagomi Kurebayashi, Hiroto Iinuma, Xi Zeng, Shuichi Mori, Masami Kodama, Takashi Murayama, Hiroyuki Masuno, Fumi Takeda, Masatoshi Kawahata, et al. A potent and selective cis-amide inhibitor of ryanodine receptor 2 as a candidate for cardiac arrhythmia treatment. European journal of medicinal chemistry. 2023. 262. 115910-115910
Atsushi Hori, Tomohiko Ai, Takashi Hato, Haruka Inaba, Kimie Tanaka, Shoichi Sato, Mizuho Okamoto, Yuna Horiuchi, Faith Jessica Paran, Yoko Tabe, et al. Carvedilol suppresses ryanodine receptor-dependent Ca2+bursts in human neurons bearingPSEN1variants found in early onset Alzheimer’s disease. 2023
Hirofumi Shimizu, Takuya Kobayashi, Masayuki Iwamoto, Kentaro Kajiwara, Nagomi Kurebayashi, Haruo Ogawa, Takashi Murayama. Single-Molecule Twisting Motions During Gating of the Human TRPV1 Channel Recorded with Sub-Millisecond Time Resolution. BIOPHYSICAL JOURNAL. 2020. 118. 3. 22A-22A
Takashi Murayama, Toshiko Yamazawa, Takuya Kobayashi, Nagomi Kurebayashi, Satoru Noguchi, Ichizo Nishino, Shuichi Mori, Hiroyuki Kagechika, Jose R. Lopez, Paul D. Allen. Therapeutic Effects of a Novel RyR1 Inhibitor on Malignant Hyperthermia-Susceptible Model Mice. BIOPHYSICAL JOURNAL. 2020. 118. 3. 98A-98A
Ryanodine Receptors: Structure Function and Dysfunction in Clinical Disease.
Springer-Verlag US 2005 ISBN:9780387231877
Calcium releasing action of quercetin on sarcoplasmic reticulum from frog skeletal muscle.
"Structure and Function of Saroplasmic Reticulum" Academic Press, 1985
Effects of a high-affinity and selective RyR2 inhibitor on Ca2+ signals in cardiomyocytes and arrhythmias in CPVT model mice
(BPS 2024 in Philadelphia 2024)
Development of RyR2 inhibitors and verification of their effects on CPVT mouse models
(Australian Physiological Society Conference, 2024 2023)
Effects of a novel RyR2 selective inhibitor on malignant arrhythmias in CPVT model mice
(10th FAOPS Congress 2023 2023)
A novel, high-affinity and selective RyR2 inhibitor effectively suppresses lethal arrhythmias in CPVT mouse models
(Gordon Research Conference, Muscle: Ecxitation Contraction Coupling 2023)
2018/03 - 現在 Journal of General Physology Editorial Advisory Board
- 現在 国際心臓研究会(ISHR)日本部会 評議員
- 現在 日本生理学会 学術評議員
- 現在 日本薬理学会 学術評議員
所属学会 (10件)：
国際心臓研究会
, 日本生化学会
, 日本循環薬理学会
, American Physiologocal Society
, 日本生理学会
, 日本生物物理学会
, 日本薬理学会
, American Physiological Society
, The Japanese Physiological Society
, Biophysical Society
