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研究者

J-GLOBAL ID：201801001298986617 更新日: 2025年03月05日

大島淳子

オオシマジュンコ | Junko Oshima

所属機関・部署：
職名： Research Professor Emeritus
その他の所属（所属・部署名・職名） (1件)：

研究分野 (1件)：内科学一般

研究キーワード (5件)：早老症 , 内科 , 老化 , ゲノム , 遺伝学

競争的資金等の研究課題 (7件)：

2019 - 2025 Genetic and Non-Genetic Modulators of Morbidity/Disability Compression in aLarge Population-Based Study of Cognitive and Physical Impairment with Emphasis on Alzheimer's Disease and Related Dementias
2021 - 2024 脂肪や血管組織老化に伴う機能変容における老化関連長鎖非コードRNAの基盤的研究
2016 - 2022 International Registry of Werner Syndrome
2017 - 2020 早老症の遺伝原因同定と、正常加齢への寄与の検索
2016 - 2018 Genetic Modulations of Morbidity Compression:A Population-Based Study

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論文 (133件)：

Tetta Sato, Yoshiro Maezawa, Hisaya Kato, Mayumi Shoji, Yukari Maeda, Hiyori Kaneko, Kazuto Aono, Yoshitaka Kubota, Toshibumi Taniguchi, Toshiyuki Oshitari, et al. For early diagnosis of young patients with Werner syndrome: Indication for genetic testing. Geriatrics & Gerontology International. 2025
Kazuto Aono, Masaya Koshizaka, Mayumi Shoji, Hiyori Kaneko, Yukari Maeda, Hisaya Kato, Yoshiro Maezawa, Makoto Miyabayashi, Mai Ishikawa, Akiko Sekiguchi, et al. Less frequent skin ulcers among patients with Werner syndrome treated with pioglitazone: findings from the Japanese Werner Syndrome Registry. Aging. 2024. 16
Danny E Miller, Lin Lee, Miranda Galey, Renuka Kandhaya-Pillai, Marc Tischkowitz, Deepak Amalnath, Avadh Vithlani, Koutaro Yokote, Hisaya Kato, Yoshiro Maezawa, et al. Targeted long-read sequencing identifies missing pathogenic variants in unsolved Werner syndrome cases. Journal of medical genetics. 2022. 59. 11. 1087-94
Renuka Kandhaya-Pillai, Deyin Hou, Jiaming Zhang, Xiaomeng Yang, Goli Compoginis, Takayasu Mori, Tamara Tchkonia, George M Martin, Fuki M Hisama, James L Kirkland, et al. SMAD4 mutations and cross-talk between TGF-β/IFNγ signaling accelerate rates of DNA damage and cellular senescence, resulting in a segmental progeroid syndrome-the Myhre syndrome. GeroScience. 2021. 43. 3. 1481-1496
Junko Oshima, George M Martin, Fuki M Hisama. Werner Syndrome. GeneReviews. 2021

MISC (7件)：

B. Saha, G. Zitnik, S. Johnson, Q. Nguyen, G. M. Martin, J. Oshima. TRF2 Degradation and DNA Damage Accumulation in LMNA Mutant Atypical Werner Syndrome Fibroblasts. IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL. 2012. 48. 48-48
J Oshima, A Garg, GM Martin, BK Kennedy. LMNA mutations in atypical Werner's syndrome - Reply. LANCET. 2003. 362. 9395. 1586-1586
MJ Moser, J Oshima, RJ Monnat. WRN mutations in Werner syndrome (vol 13, pg 271, 1998). HUMAN MUTATION. 1999. 14. 1. 84-85
L Ye, T Miki, J Nakura, J Oshima, A Morishima, H Rakugi, H Ikegami, J Higaki, D Edland, M Martin, et al. A polymorphic variant of Werner syndrome gene (WRN) association with myocardial infarction (MI) in Japanese population. AMERICAN JOURNAL OF HUMAN GENETICS. 1997. 61. 4. A301-A301
L Ye, T Miki, J Nakura, J Oshima, K Kamino, H Rakugi, H Ikegami, J Higaki, SD Edland, GM Martin, et al. Rapid publication: Association of a polymorphic variant of the Werner helicase gene with myocardial infarction in a Japanese population (vol 68, pg 494, 1997). AMERICAN JOURNAL OF MEDICAL GENETICS. 1997. 70. 1. 103-103

講演・口頭発表等 (18件)：

The Spectrum of WRN Mutations in Werner Syndrome Patients
(日本老年医学会 2021)
Genetics of Aging: Molecular Mechanisms of Progeroid Syndromes”
(Seminars in Medical Sciences Series, 2019)
Genetics of Aging: Molecular Mechanisms of Progeroid Syndromes
(Leading Seminar, Chiba University 2019)
International Registry of Werner Syndrome: Search for progeroid syndrome mutations and mechanisms
(Cold Spring Harbor Laboratory Meeting “Mechanism of Aging”. 2018)
International Registry of Werner Syndrome: Search for progeroid syndrome mutations and mechanisms
(International Meeting on RECQ Helicases and Related Diseases 2018, 2018)

学歴 (3件)：

学位 (2件)：

経歴 (13件)：

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委員歴 (19件)：

2006/01 - 現在 American Federation for Aging Research, New York, NY National Scientific Advisory
2021/04 - NIH study section, NIH NIA ZAG1 LRP
2020/04 - NIH study section, NIH NIA ZAG1 LRP
2019/05 - NIH study section NIH NIA ZAG1 ZIJ-4 (M5) LRP
2018/10 - NIH study section NIH NIA ZAG1 ZIJ-G (J4) PPG

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受賞 (1件)：

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大島 淳子