栁谷朗子

ヤナギヤアキコ | Yanagiya Akiko

所属機関・部署：
職名：研究員

研究分野 (5件)：腫瘍生物学 , 細胞生物学 , 分子生物学 , 動物生理化学、生理学、行動学 , 実験動物学

研究キーワード (7件)：膵β細胞の恒常性維持 , m6A修飾RNA , 糖尿病 , インスリン生合成 , 翻訳制御 , mRNA分解 , 転写後制御

競争的資金等の研究課題 (4件)：

2022 - 2024 膵β細胞の恒常性維持に必要なm6A修飾を介したmRNA分解制御の解析
2020 - 2022 膵β細胞の恒常性維持に重要なオートファジーの転写後制御の解析
2018 - 2021 膵β細胞でのグルコース応答性インスリン分泌における転写後調節の分子機構の解析
2004 - 2006 RNAウイルスの病原性における翻訳制御の解析

論文 (32件)：

Patrick N Stoney, Akiko Yanagiya, Saori Nishijima, Tadashi Yamamoto. CNOT7 Outcompetes Its Paralog CNOT8 for Integration into The CCR4-NOT Complex. Journal of molecular biology. 2022. 434. 9. 167523-167523
Shohei Takaoka, Akiko Yanagiya, Haytham Mohamed Aly Mohamed, Rei Higa, Takaya Abe, Ken-Ichi Inoue, Akinori Takahashi, Patrick Stoney, Tadashi Yamamoto. Neuronal XRN1 is required for maintenance of whole-body metabolic homeostasis. iScience. 2021. 24. 10. 103151-103151
Patrick Sénéchal, Francis Robert, Regina Cencic, Akiko Yanagiya, Jennifer Chu, Nahum Sonenberg, Marilène Paquet, Jerry Pelletier. Assessing eukaryotic initiation factor 4F subunit essentiality by CRISPR-induced gene ablation in the mouse. Cellular and molecular life sciences : CMLS. 2021. 78. 19-20. 6709-6719
Dina Mostafa, Akiko Yanagiya, Eleni Georgiadou, Yibo Wu, Theodoros Stylianides, Guy A. Rutter, Toru Suzuki, Tadashi Yamamoto. Loss of β-cell identity and diabetic phenotype in mice caused by disruption of CNOT3-dependent mRNA deadenylation. Communications Biology. 2020. 3. 1. 476-476
Akinori Takahashi, Toru Suzuki, Shou Soeda, Shohei Takaoka, Shungo Kobori, Tomokazu Yamaguchi, Haytham Mohamed Aly Mohamed, Akiko Yanagiya, Takaya Abe, Mayo Shigeta, et al. The CCR4-NOT complex maintains liver homeostasis through mRNA deadenylation. Life Science Alliance. 2020. 3. 5

MISC (8件)：

Sooncheol Lee, Syed I. A. Bukhari, Samuel S. Truesdell, Swapna Kollu, Anthony Classon, Myriam Boukhali, Esha Jain, David Sweetser, Richard D. Mortensen, Akiko Yanagiya, et al. A specialized translation program in quiescent cancer cells. CLINICAL CANCER RESEARCH. 2017. 23. 24. 30-30
Shobha Vasudevan, Syed Irfan Ahmed Bukhari, Samuel Spencer Truesdell, Sooncheol Lee, Swapna Kollu, Anthony Classon, Myriam Boukhali, Esha Jain, Akiko Yanagiya, Ruslan Sadyrev, et al. A Specialized Mechanism of MicroRNA-mediated Translation in Quiescence. FASEB JOURNAL. 2016. 30
Shobha Vasudevan, Syed Irfan Ahmed Bukhari, Samuel Spencer Truesdell, Sooncheol Lee, Swapna Kollu, Anthony Classon, Myriam Boukhali, Esha Jain, Akiko Yanagiya, Ruslan Sadyrev, et al. A Specialized Mechanism of MicroRNA-mediated Translation in Quiescence. FASEB JOURNAL. 2016. 30
Peter S. Vosler, Yanqin Gao, Christopher S. Brennan, Akiko Yanagiya, Yu Gan, Guodong Cao, Feng Zhang, Simon J. Morley, Nahum Sonenberg, Michael V. L. Bennett, et al. NEUROSCIENCE (vol 108, pg 18102, 2011). PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013. 110. 49. 19968-19968
Peter S. Vosler, Yanqin Gao, Christopher S. Brennan, Akiko Yanagiya, Yu Gan, Guodong Cao, Feng Zhang, Simon J. Morley, Nahum Sonenberg, Michael V. L. Bennett, et al. Ischemia-induced calpain activation causes eukaryotic (translation) initiation factor 4G1 (eIF4GI) degradation, protein synthesis inhibition, and neuronal death (vol 108, pg 18102, 2011). PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012. 109. 10. 4021-4021

講演・口頭発表等 (26件)：

Post-transcriptional regulation in insulin biosynthesis by the Ccr4-Not deadenylase complex in mouse pancreatic islets.
(第20回日本RNA学会年会 2018)
Post-transcriptional regulation in glucose-stimulated insulin biosynthesis by the Ccr4-Not deadenylase complex in mouse pancreatic islets.
(The 23rd Annual Meeting of the RNA Society 2018)
Post-transcriptional regulation via the mRNA poly(A) tail during spermatogenesis.
(第40回日本分子生物学会年会 2017)
Translational control in spermatogenesis by poly(A)-binding protein-interacting protein 1.
(第19回日本RNA学会年会 2017)
The physiological role of poly(A)-binding protein-interacting protein 1 in male germ cell development and memory formation.
(Invited lecture at The Okinawa Institute of Science and Technology Graduate University 2016)

学位 (1件)：

博士(薬学) (東京大学)

経歴 (5件)：

2017/04 - 2022/04 沖縄科学技術大学院大学
2008/04 - 2017/04 マギル大学生化学講座リサーチアソシエート
2003/06 - 2008/03 マギル大学生化学講座博士研究員
2004/04 - 2006/03 マギル大学生化学講座日本学術振興会海外特別研究員
2003/04 - 2003/06 東京大学大学院医学系研究科医学系研究科研究員

受賞 (2件)：

2011/03 - McGill University McGill MedStar Award
2004/04 - 日本学術振興会海外特別研究員

所属学会 (3件)：

日本分子生物学会 , RNA学会 , 日本RNA学会

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