研究者
J-GLOBAL ID：202401013546570347
更新日: 2025年03月12日 Coppo Roberto
コッポ ロベルト | Coppo Roberto
京都大学大学院医学研究科 クリニカルバイオリソース研究開発講座
京都大学大学院医学研究科 クリニカルバイオリソース研究開発講座 について
職名： 博士研究員
ホームページURL (1件)： https://cbrrd.med.kyoto-u.ac.jp/index.html
研究キーワード (5件)：
Mechanisms of non-genetic resistance in cancer
, CRISPR gene editing
, Bioinformatics
, Cancer cell plasticity
, Organoid cultures for cancer modeling
競争的資金等の研究課題 (2件)： - 2023 - 2025 細胞傷害性がん治療法による残存がん細胞の再生メカニズムの解明と標的化
- 2022 - 2023 Functional single-cell analysis of the stem cell plasticity associated with drug-tolerant persister cells in colorectal cancer
- Yoshiaki Matsuura, Kunishige Onuma, Roberto Coppo, Hiroyuki Uematsu, Jumpei Kondo, Aya Miyagawa-Hayashino, Naoko Takeda-Miyata, Kenji Kameyama, Tatsuo Furuya, Satoru Okada, et al. Dynamic change of polarity in spread through air spaces of pulmonary malignancies. The Journal of Pathology. 2025
- Yi-Kai Lin, Roberto Coppo, Kunishige Onuma, Hiroko Endo, Jumpei Kondo, Sadahiro Iwabuchi, Shinichi Hashimoto, Yoshiro Itatani, Kazutaka Obama, Masahiro Inoue. Growth pattern of de novo small clusters of colorectal cancer is regulated by Notch signaling at detachment. Cancer Science. 2024
- Masamune Masuda, Keita Iida, Sadahiro Iwabuchi, Mie Tanaka, Satoshi Kubota, Hiroyuki Uematsu, Kunishige Onuma, Yoji Kukita, Kikuya Kato, Shoji Kamiura, et al. Clonal Origin and Lineage Ambiguity in Mixed Neuroendocrine Carcinoma of the Uterine Cervix. The American Journal of Pathology. 2024. 194. 3. 415-429
- Roberto Coppo, Jumpei Kondo, Kunishige Onuma, Masahiro Inoue. Tracking the growth fate of single cells and isolating slow-growing cells in human colorectal cancer organoids. STAR Protocols. 2023. 4. 3. 102395-102395
- Hiroyuki Uematsu, Chieko Saito, Jumpei Kondo, Kunishige Onuma, Roberto Coppo, Yukiko Mori, Manabu Muto, Yuichiro Kikawa, Manami Tada, Tomoharu Sugie, et al. De-differentiation in cultures of organoids from luminal-type breast cancer is restored by inhibition of NOTCH signaling. Human Cell. 2023. 36. 6. 2099-2112
- Mie Tanaka, Jumpei Kondo, Kensuke Kaneko, Hiroko Endo, Kunishige Onuma, Roberto Coppo, Masamune Masuda, Shoji Kamiura, Kiyoshi Yoshino, Yutaka Ueda, et al. Heterogenous chemosensitivity of a panel of organoid lines derived from small cell neuroendocrine carcinoma of the uterine cervix (Mar, 10.1007/s13577-021-00511-5, 2021). HUMAN CELL. 2021. 34. 3. 1028-1030
- Coppo Roberto, 近藤 純平, 遠藤 洋子, 井上 正宏. Cancer Tissue-Originated Spheroid(CTOS)法を用いた結腸直腸癌における腫瘍内多様性の解析(Characterization of tumor subclonal heterogeneity in colorectal cancer using cancer tissue-originated spheroid method). 日本癌学会総会記事. 2018. 77回. 1207-1207
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緩慢増殖する大腸がん細胞亜群における遺伝的脆弱性を特定するためのCRISPRドロップアウトスクリーニング
(第83回日本癌学会学術総会 2024) -
Epigenetic regulation of drug-tolerant persister (DTP) cell regrowth after chemotherapy in colorectal cancer organoids
(The 28th Annual Meeting of Japanese Association for Molecular Target Therapy of Cancer, Tokyo 2024) -
Unraveling non-genetic heterogeneity, cellular plasticity, and drug resistance in patient-derived colorectal cancer organoids
(65th Advanced Research Seminar, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo 2024) -
Analysis of intra-tumor heterogeneity in colorectal cancer using the cancer tissue-originated spheroid (CTOS) method
(77th Annual Meeting of the Japanese Cancer Association, Osaka 2018) -
Role of ESDN/DCBLD2/CLCP1 protein in melanoma progression
(ABCD Meeting "Mechanisms of signal transduction", Padua, Italy 2014)
- 2013 - 2017 University of Turin Dept. Molecular Biotechnology and Health Sciences Doctoral (Ph.D.) in Life and Health Sciences, Biomedical Sciences and Oncology
- PhD in Biomedical Sciences and Oncology
- 2024/09 - 現在 京都大学大学院医学研究科 クリニカルバイオリソース研究開発講座
- 2022/09 - 2024/08 京都大学大学院医学研究科 クリニカルバイオリソース研究開発講座
- 2018/04 - 2022/08 京都大学大学院医学研究科 クリニカルバイオリソース研究開発講座
- 2017/04 - 2018/03 大阪国際がんセンター研究所生化学部
- 2022/07 - JSPS International Fellowships for Research in Japan, Postdoctoral Fellowship (Standard), issued by the Japan Society for the Promotion of Science
- 2022/04 - EARLY-CAREER SCIENTISTS, GRANTS-IN-AID FOR SCIENTIFIC RESEARCH-KAKENHI (22K15539), issued by KAKEN
- 2013/01 - Ph.D (Doctor of Philosophy) Scholarship, Ph.D Program in Biomedical Sciences and Oncology, Cycle XXVIII, issued by the University of Turin, Italy
The Japanese Association for Molecular Target Therapy of Cancer
, The Japanese Association for Metastasis Research
, The Japanese Cancer Association
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