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論文 (31件)
- Tatsuya Kikuchi, Toshimitsu Okamura, Ming-Rong Zhang. Efficient Reductive N-11C-Methylation Using Arylamines or Alkylamines and In Situ-Generated [11C]Formaldehyde From [11C]Methyl Iodide. Journal of labelled compounds & radiopharmaceuticals. 2024
- Toshimitsu Okamura, Tatsuya Kikuchi, Masanao Ogawa, Ming-Rong Zhang. Improved synthesis of 6-bromo-7-[11C]methylpurine for clinical use. EJNMMI radiopharmacy and chemistry. 2024. 9. 1. 10
- Hideki Ishii, Tomoteru Yamasaki, Toshimitsu Okamura, Yiding Zhang, Yusuke Kurihara, Masanao Ogawa, Nobuki Nengaki, Ming-Rong Zhang. Evaluation and improvement of CuI-mediated 11 C-cyanation. Journal of labelled compounds & radiopharmaceuticals. 2023. 66. 3. 95-107
- Toshimitsu Okamura, Satoshi Tsukamoto, Maki Okada, Tatsuya Kikuchi, Ryutaro Aizawa, Hidekatsu Wakizaka, Nobuki Nengaki, Masanao Ogawa, Hideki Ishii, Ming-Rong Zhang. 11C-Labeled Radiotracer for Noninvasive and Quantitative Assessment of the Thiocyanate Efflux System in the Brain. Bioconjugate chemistry. 2022. 33. 9. 1654-1662
- Tatsuya Kikuchi, Masanao Ogawa, Toshimitsu Okamura, Antony D. Gee, Ming-Rong Zhang. Rapid 'on-column' preparation of hydrogen [C-11]cyanide from [C-11]methyl iodide via [C-11]formaldehyde. CHEMICAL SCIENCE. 2022. 13. 12. 3556-3562
- Toshimitsu Okamura, Satoshi Tsukamoto, Kotaro Nagatsu, Maki Okada, Katsuyuki Minegishi, Takayuki Tatsumi, Aya Sugyo, Tatsuya Kikuchi, Hidekatsu Wakizaka, Hideki Ishii, et al. 6-[124I]Iodo-9-pentylpurine for Imaging the Activity of the Sodium Iodide Symporter in the Brain. Journal of medicinal chemistry. 2020. 63. 4. 1717-1723
- Toshimitsu Okamura, Maki Okada, Tatsuya Kikuchi, Hidekatsu Wakizaka, Ming-Rong Zhang. Mechanisms of glutathione-conjugate efflux from the brain into blood: Involvement of multiple transporters in the course. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2020. 40. 1. 116-125
- Toshimitsu Okamura, Maki Okada, Tatsuya Kikuchi, Hidekatsu Wakizaka, Ming-Rong Zhang. Kinetics and metabolism of apocynin in the mouse brain assessed with positron-emission tomography. Phytomedicine. 2018. 38. 84-89
- Tatsuya Kikuchi, Toshimitsu Okamura, Maki Okada, Masanao Ogawa, Chie Suzuki, Hidekatsu Wakizaka, Joji Yui, Toshimitsu Fukumura, Antony D. Gee, Ming-Rong Zhang. Benzyl [C-11]Hippurate as an Agent for Measuring the Activities of Organic Anion Transporter 3 in the Brain and Multidrug Resistance-Associated Protein 4 in the Heart of Mice. JOURNAL OF MEDICINAL CHEMISTRY. 2016. 59. 12. 5847-5856
- Okamura T, Okada M, Kikuchi T, Wakizaka H, Zhang MR. A 11C-labeled 1,4-dihydroquinoline derivative as a potential PET tracer for imaging of redox status in mouse brain. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2015. 35. 12. 1930-1936
- Maki Okada, Tatsuya Kikuchi, Toshimitsu Okamura, Yoko Ikoma, Atsushi B. Tsuji, Hidekatsu Wakizaka, Tomoo Kamakura, Ichio Aoki, Ming-Rong Zhang, Koichi Kato. In-vivo imaging of blood-brain barrier permeability using positron emission tomography with 2-amino-[3-C-11] isobutyric acid. NUCLEAR MEDICINE COMMUNICATIONS. 2015. 36. 12. 1239-1248
- Tatsuya Kikuchi, Toshimitsu Okamura, Hidekatsu Wakizaka, Maki Okada, Kenichi Odaka, Joji Yui, Atsushi B. Tsuji, Toshimitsu Fukumura, Ming-Rong Zhang. OAT3-mediated extrusion of the Tc-99m-ECD metabolite in the mouse brain. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2014. 34. 4. 585-588
- Eva Galante, Toshimitsu Okamura, Kerstin Sander, Tatsuya Kikuchi, Maki Okada, Ming-Rong Zhang, Mathew Robson, Adam Badar, Mark Lythgoe, Matthias Koepp, et al. Development of Purine-Derived F-18-Labeled Pro-drug Tracers for Imaging of MRP1 Activity with PET. JOURNAL OF MEDICINAL CHEMISTRY. 2014. 57. 3. 1023-1032
- Toshimitsu Okamura, Tatsuya Kikuchi, Maki Okada, Hidekatsu Wakizaka, Ming-Rong Zhang. Imaging of Activity of Multidrug Resistance-Associated Protein 1 in the Lungs. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY. 2013. 49. 3. 335-340
- Maki Okada, Ryuji Nakao, Sotaro Momosaki, Kazuhiko Yanamoto, Tatsuya Kikuchi, Toshimitsu Okamura, Hidekatsu Wakizaka, Rie Hosoi, Ming-Rong Zhang, Osamu Inoue. Improvement of brain uptake for in vivo PET imaging of astrocytic oxidative metabolism using benzyl [1-11C]acetate. Applied Radiation and Isotopes. 2013. 78. 102-107
- Tatsuya Kikuchi, Toshimitsu Okamura, Ming-Rong Zhang, Toshiaki Irie. PET probes for imaging brain acetylcholinesterase. Journal of Labelled Compounds and Radiopharmaceuticals. 2013. 56. 3-4. 172-179
- Toshimitsu Okamura, Tatsuya Kikuchi, Mika Nodaira, Kenichi Odaka, Kiyoshi Fukushi, Toshiaki Irie. Effects of Halogenation on Tyrosine Phosphorylation and Peptide Binding to the Src Homology 2 Domain of Lymphocyte-Specific Protein Tyrosine Kinase. BIOLOGICAL & PHARMACEUTICAL BULLETIN. 2012. 35. 3. 433-437
- Tomoyuki Ohya, Toshimitsu Okamura, Yuji Nagai, Kiyoshi Fukushi, Toshiaki Irie, Tetsuya Suhara, Ming-Rong Zhang, Toshimitsu Fukumura, Tatsuya Kikuchi. Effect of radiolabeled metabolite elimination from the brain on the accuracy of cerebral enzyme activity estimation using positron emission tomography with substrate tracers. NEUROIMAGE. 2011. 56. 3. 1105-1110
- Tatsuya Kikuchi, Maki Okada, Nobuki Nengaki, Kenji Furutsuka, Hidekatsu Wakizaka, Toshimitsu Okamura, Ming-Rong Zhang, Koichi Kato. Efficient synthesis and chiral separation of C-11-labeled ibuprofen assisted by DMSO for imaging of in vivo behavior of the individual isomers by positron emission tomography. BIOORGANIC & MEDICINAL CHEMISTRY. 2011. 19. 10. 3265-3273
- T. Okamura, T. Kikuchi, T. Irie. PET Imaging of MRP1 Function in the Living Brain: Method Development and Future Perspectives. CURRENT TOPICS IN MEDICINAL CHEMISTRY. 2010. 10. 17. 1810-1819
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