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論文 (49件)
- Keiji Nishiwaki, Shiori Nakatani, Shinya Nakamura, Kenji Yoshioka, Eri Nakagawa, Masato Tsuyuguchi, Takayoshi Kinoshita, Isao Nakanishi. Enhanced inhibitory activity of compounds containing purine scaffolds compared to protein kinase CK2α considering crystalline water. RSC Medicinal Chemistry. 2024
- Keiji Nishiwaki, Shinya Nakamura, Kenji Yoshioka, Eri Nakagawa, Shiori Nakatani, Masato Tsuyuguchi, Takayoshi Kinoshita, Isao Nakanishi. Design, Synthesis and Structure-Activity Relationship Studies of Protein Kinase CK2 Inhibitors Containing a Purine Scaffold. Chemical and Pharmaceutical Bulletin. 2023. 71. 7. 558-565
- Asaka Ikeda, Masato Tsuyuguchi, Daisuke Kitagawa, Masaaki Sawa, Shinya Nakamura, Isao Nakanishi, Takayoshi Kinoshita. Bivalent binding mode of an amino-pyrazole inhibitor indicates the potentials for CK2α1-selective inhibitors. Biochemical and biophysical research communications. 2022. 630. 30-35
- Yuka Murakawa, Shirly Valter, Haim Barr, Nir London, Takayoshi Kinoshita. Structural basis for producing selective MAP2K7 inhibitors. Bioorganic and Medicinal Chemistry Letters. 2020. 30. 22
- Masato Tsuyuguchi, Tetsuko Nakaniwa, Akira Hirasawa, Isao Nakanishi, Takayoshi Kinoshita. Structural insights for producing CK2α1-specific inhibitors. Bioorganic and Medicinal Chemistry Letters. 2020. 30. 2
- Noritaka Furuya, Takaki Momose, Kenji Katsuno, Nobuhiko Fushimi, Hideyuki Muranaka, Chiaki Handa, Masaaki Sawa, Tomonaga Ozawa, Takayoshi Kinoshita. An isoform-selective inhibitor of tropomyosin receptor kinase A behaves as molecular glue. Bioorganic and Medicinal Chemistry Letters. 2020. 30. 1
- Takashi Matsumoto, Akihito Yamano, Yuka Murakawa, Harumi Fukada, Masaaki Sawa, Takayoshi Kinoshita. Ensemble structural analyses depict the regulatory mechanism of non-phosphorylated human MAP2K4. Biochemical and Biophysical Research Communications. 2020. 521. 1. 106-112
- Tsuyoshi Oshima, Yoshimi Niwa, Keiko Kuwata, Ashutosh Srivastava, Tomoko Hyoda, Yoshiki Tsuchiya, Megumi Kumagai, Masato Tsuyuguchi, Teruya Tamaru, Akiko Sugiyama, et al. Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth. Science Advances. 2019. 5. 1
- Amit Shraga, Evgenia Olshvang, Natalia Davidzohn, Payam Khoshkenar, Nicolas Germain, Khriesto Shurrush, Silvia Carvalho, Liat Avram, Shira Albeck, Tamar Unger, et al. Covalent Docking Identifies a Potent and Selective MKK7 Inhibitor. Cell Chemical Biology. 2019. 26. 1. 98-108.e5
- Masato Tsuyuguchi, Tetsuko Nakaniwa, Masaaki Sawa, Isao Nakanishi, Takayoshi Kinoshita. A promiscuous kinase inhibitor delineates the conspicuous structural features of protein kinase CK2a1. Acta Crystallographica Section F: Structural Biology Communications. 2019. 75. 515-519
- Takayoshi Kinoshita. Protein allostery in rational drug design. Advances in Experimental Medicine and Biology. 2019. 1163. 45-64
- Chie Shibazaki, Shigeki Arai, Rumi Shimizu, Morihisa Saeki, Takayoshi Kinoshita, Andreas Ostermann, Tobias E. Schrader, Yuzuru Kurosaki, Tomoko Sunami, Ryota Kuroki, et al. Hydration Structures of the Human Protein Kinase CK2α Clarified by Joint Neutron and X-ray Crystallography. Journal of Molecular Biology. 2018. 430. 24. 5094-5104
- Masato Tsuyuguchi, Tetsuko Nakaniwa, Takayoshi Kinoshita. Crystal structures of human CK2α2 in new crystal forms arising from a subtle difference in salt concentration. Acta Crystallographica Section F Structural Biology Communications. 2018. 74. 5. 288-293
- Takayoshi Kinoshita, Takuma Hashimoto, Yuri Sogabe, Harumi Fukada, Takashi Matsumoto, Masaaki Sawa. High-resolution structure discloses the potential for allosteric regulation of mitogen-activated protein kinase kinase 7. Biochemical and Biophysical Research Communications. 2017. 493. 1. 313-317
- Noritaka Furuya, Takaki Momose, Kenji Katsuno, Nobuhiko Fushimi, Hideyuki Muranaka, Chiaki Handa, Tomonaga Ozawa, Takayoshi Kinoshita. The juxtamembrane region of TrkA kinase is critical for inhibitor selectivity. Bioorganic and Medicinal Chemistry Letters. 2017. 27. 5. 1233-1236
- Yuri Sogabe, Takuma Hashimoto, Takashi Matsumoto, Yasuyuki Kirii, Masaaki Sawa, Takayoshi Kinoshita. A crucial role of Cys218 in configuring an unprecedented auto-inhibition form of MAP2K7. Biochemical and Biophysical Research Communications. 2016. 473. 2. 476-481
- Hiroaki Ohno, Daiki Minamiguchi, Shinya Nakamura, Keito Shu, Shiho Okazaki, Maho Honda, Ryosuke Misu, Hirotomo Moriwaki, Shinsuke Nakanishi, Shinya Oishi, et al. Structure-activity relationship study of 4-(thiazol-5-yl)benzoic acid derivatives as potent protein kinase CK2 inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY. 2016. 24. 5. 1136-1141
- Takayoshi Kinoshita, Hajime Sugiyama, Yurika Mori, Naruhide Takahashi, Atsushi Tomonaga. Identification of allosteric ERK2 inhibitors through in silico biased screening and competitive binding assay. Bioorganic and Medicinal Chemistry Letters. 2016. 26. 3. 955-958
- Isao Nakanishi, Katsumi Murata, Naoya Nagata, Masakuni Kurono, Takayoshi Kinoshita, Misato Yasue, Takako Miyazaki, Yoshinori Takei, Shinya Nakamura, Atsushi Sakurai, et al. Identification of protein kinase CK2 inhibitors using solvent dipole ordering virtual screening. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 2015. 96. 396-404
- Yuri Sogabe, Takashi Matsumoto, Takuma Hashimoto, Yasuyuki Kirii, Masaaki Sawa, Takayoshi Kinoshita. 5Z-7-Oxozeaenol covalently binds to MAP2K7 at Cys218 in an unprecedented manner. Bioorganic and Medicinal Chemistry Letters. 2015. 25. 3. 593-596
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