文献

J-GLOBAL ID：201902257920965199   整理番号：19A2443825

自閉症関連蛋白質キナーゼD2は胚皮質ニューロン発生を調節する【JST・京大機械翻訳】

Autism-associated protein kinase D2 regulates embryonic cortical neuron development

著者 (33件)： Matsumura Kensuke (Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, 565-0871, Japan) ,  Matsumura Kensuke (Interdisciplinary Program for Biomedical Sciences, Institute for Transdisciplinary Graduate Degree Programs, Osaka University, Suita, Osaka, 565-0871, Japan) ,  Matsumura Kensuke (Research Fellowships for Young Scientists of the Japan Society for the Promotion of Science, Chiyoda-ku, Tokyo, 102-0083, Japan) ,  Baba Masayuki (Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, 565-0871, Japan) ,  Nagayasu Kazuki (Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, 565-0871, Japan) ,  Yamamoto Kana (Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, 565-0871, Japan) ,  Kondo Momoka (Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, 565-0871, Japan) ,  Kitagawa Kohei (Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, 565-0871, Japan) ,  Takemoto Tomoya (Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, 565-0871, Japan) ,  Seiriki Kaoru (Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, 565-0871, Japan) ,  Seiriki Kaoru (Interdisciplinary Program for Biomedical Sciences, Institute for Transdisciplinary Graduate Degree Programs, Osaka University, Suita, Osaka, 565-0871, Japan) ,  Kasai Atsushi (Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, 565-0871, Japan) ,  Ago Yukio (Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, 565-0871, Japan) ,  Ago Yukio (Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, 565-0871, Japan) ,  Hayata-Takano Atsuko (Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, 565-0871, Japan) ,  Hayata-Takano Atsuko (United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Suita, Osaka, 565-0871, Japan) ,  Shintani Norihito (Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, 565-0871, Japan) ,  Kuriu Toshihiko (Osaka Medical College, Research and Development Center, Takatsuki, Osaka, 569-8686, Japan) ,  Iguchi Tokuichi (Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, Suita, Osaka, 565-0871, Japan) ,  Sato Makoto (United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Suita, Osaka, 565-0871, Japan) ,  Sato Makoto (Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, Suita, Osaka, 565-0871, Japan) ,  Sato Makoto (Research Center for Child Mental Development, University of Fukui, Yoshida-gun, Fukui, 910-1193, Japan) ,  Takuma Kazuhiro (United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Suita, Osaka, 565-0871, Japan) ,  Takuma Kazuhiro (Department of Pharmacology, Graduate School of Dentistry, Osaka University, Suita, Osaka, 565-0871, Japan) ,  Hashimoto Ryota (Department of Pathology of Mental Diseases, National Institute of Mental Health, National Center of Neurology and Psychiatry, Kodaira, Tokyo, 187-8553, Japan) ,  Hashimoto Ryota (Osaka University, Suita, Osaka, 565-0871, Japan) ,  Hashimoto Hitoshi (Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, 565-0871, Japan) ,  Hashimoto Hitoshi (United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Suita, Osaka, 565-0871, Japan) ,  Hashimoto Hitoshi (Division of Bioscience, Institute for Datability Science, Osaka University, Suita, Osaka, 565-0871, Japan) ,  Hashimoto Hitoshi (Transdimensional Life Imaging Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Osaka, 565-0871, Japan) ,  Hashimoto Hitoshi (Department of Molecular Pharmaceutical Science, Graduate School of Medicine, Osaka University, Suita, Osaka, 565-0871, Japan) ,  Nakazawa Takanobu (Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, 565-0871, Japan) ,  Nakazawa Takanobu (Department of Pharmacology, Graduate School of Dentistry, Osaka University, Suita, Osaka, 565-0871, Japan)
資料名： Biochemical and Biophysical Research Communications  (Biochemical and Biophysical Research Communications)
巻： 519  号： 3  ページ： 626-632  発行年： 2019年 
JST資料番号： B0118A  ISSN： 0006-291X  資料種別： 逐次刊行物 (A)
記事区分： 短報  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： 自閉症スペクトラム障害(ASD)は,不均一な神経発達障害であり,社会的相互作用の障害,反復行動および制限された興味により特徴付けられる。ASDの分子病因はほとんど知られていないが,最近の研究はde novo変異がASDのリスクに有意に関与していることを示唆している。著者らは最近,散発性ASD症例において,蛋白質キナーゼDファミリーメンバー,PKD2における自発的de novo変異を同定した。しかしながら,de novo PKD2変異の生物学的意義と脳発生におけるPKD2の役割は不明のままである。ここでは,子宮内エレクトロポレーションを用いた皮質ニューロン発生におけるPKD2の機能解析を行った。PKD2は発達中の皮質における皮質神経幹細胞において高度に発現し,神経幹細胞のニューロン分化と新生ニューロンの移動を含む皮質ニューロン発生を調節する。重要なことに,ASD関連de novo変異はPKD2のキナーゼ活性を損なうことを決定し,de novo PKD2変異がPKD2の機能喪失による疾患の危険因子であることを示唆した。著者らの現在の知見はASDの分子的および細胞的病因への新しい洞察を提供する。Copyright 2019 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： *皮質 ,  エレクトロポレーション ,  変異 ,  分化 ,  神経幹細胞 ,  *ニューロン ,  子宮 ,  危険因子 ,  *自閉症 ,  病因
準シソーラス用語： *キナーゼ ,  脳発生 ,  神経発達障害 ,  自閉症スペクトラム障害 ,  *皮質ニューロン , 【Automatic Indexing@JST】

著者キーワード (6件)： - ,  - ,  - ,  - ,  - ,  -

分類 (1件)： 細胞生理一般  (EF02010S)

タイトルに関連する用語 (4件)： 自閉症 ,  胚 ,  皮質ニューロン ,  調節