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論文 (46件)
- Seongjoon Park, Toshimitsu Komatsu, Hiroko Hayashi, Ryoichi Mori, Isao Shimokawa. The Role of Neuropeptide Y in Adipocyte-Macrophage Crosstalk during High Fat Diet-Induced Adipose Inflammation and Liver Steatosis. Biomedicines. 2021. 9. 11. 1739-1739
- Seongjoon Park, Erkhembayar Nayantai, Toshimitsu Komatsu, Hiroko Hayashi, Ryoichi Mori, Isao Shimokawa. NPY Deficiency Prevents Postmenopausal Adiposity by Augmenting Estradiol-Mediated Browning. The journals of gerontology. Series A, Biological sciences and medical sciences. 2020. 75. 6. 1042-1049
- Zi Wang, Toshimitsu Komatsu, Yoshihisa Ohata, Yukari Watanabe, Yiwen Yuan, Yuki Yoshii, Seongjoon Park, Ryoichi Mori, Motoyasu Satou, Yoshitaka Kondo, et al. Effects of rikkunshito supplementation on resistance to oxidative stress and lifespan in mice. Geriatrics & gerontology international. 2020. 20. 3. 238-247
- Toshimitsu Komatsu, Seongjoon Park, Hiroko Hayashi, Ryoichi Mori, Haruyoshi Yamaza, Isao Shimokawa. Mechanisms of Calorie Restriction: A Review of Genes Required for the Life-Extending and Tumor-Inhibiting Effects of Calorie Restriction. Nutrients. 2019. 11. 12
- Maiko de Kerckhove, Katsuya Tanaka, Takahiro Umehara, Momoko Okamoto, Sotaro Kanematsu, Hiroko Hayashi, Hiroki Yano, Soushi Nishiura, Shiho Tooyama, Yutaka Matsubayashi, et al. Targeting miR-223 in neutrophils enhances the clearance of Staphylococcus aureus in infected wounds. EMBO molecular medicine. 2018. 10. 10
- Katsuya Tanaka, Sang Eun Kim, Hiroki Yano, Gaku Matsumoto, Ryoma Ohuchida, Yuhoko Ishikura, Masatake Araki, Kimi Araki, Seongjoon Park, Toshimitsu Komatsu, et al. MiR-142 Is Required for Staphylococcus aureus Clearance at Skin Wound Sites via Small GTPase-Mediated Regulation of the Neutrophil Actin Cytoskeleton. The Journal of investigative dermatology. 2017. 137. 4. 931-940
- Seongjoon Park, Toshimitsu Komatsu, Sang Eun Kim, Katsuya Tanaka, Hiroko Hayashi, Ryoichi Mori, Isao Shimokawa. Neuropeptide Y resists excess loss of fat by lipolysis in calorie-restricted mice: a trait potential for the life-extending effect of calorie restriction. Aging cell. 2017. 16. 2. 339-348
- Isao Shimokawa, Toshimitsu Komatsu, Nobutaka Hayashi, Sang-Eun Kim, Takuya Kawata, Seongjoon Park, Hiroko Hayashi, Haruyoshi Yamaza, Takuya Chiba, Ryoichi Mori. The life-extending effect of dietary restriction requires Foxo3 in mice. Aging cell. 2015. 14. 4. 707-9
- Sang-Eun Kim, Ryoichi Mori, Toshimitsu Komatsu, Takuya Chiba, Hiroko Hayashi, Seongjoon Park, Michiru D Sugawa, Norbert A Dencher, Isao Shimokawa. Upregulation of cytochrome c oxidase subunit 6b1 (Cox6b1) and formation of mitochondrial supercomplexes: implication of Cox6b1 in the effect of calorie restriction. Age (Dordrecht, Netherlands). 2015. 37. 3. 9787-9787
- Ryotaro Kamohara, Haruyoshi Yamaza, Tomoshi Tsuchiya, Toshimitsu Komatsu, Seongjoon Park, Hiroko Hayashi, Takuya Chiba, Ryoichi Mori, Shuichi Otabe, Kentaro Yamada, et al. Overexpression of the adiponectin gene mimics the metabolic and stress resistance effects of calorie restriction, but not the anti-tumor effect. Experimental gerontology. 2015. 64. 46-54
- Seongjoon Park, Chika Fujishita, Toshimitsu Komatsu, Sang Eun Kim, Takuya Chiba, Ryoichi Mori, Isao Shimokawa. NPY antagonism reduces adiposity and attenuates age-related imbalance of adipose tissue metabolism. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2014. 28. 12. 5337-48
- Ryoichi Mori, Katsuya Tanaka, Maiko de Kerckhove, Momoko Okamoto, Kazuya Kashiyama, Katsumi Tanaka, Sangeun Kim, Takuya Kawata, Toshimitsu Komatsu, Seongjoon Park, et al. Reduced FOXO1 expression accelerates skin wound healing and attenuates scarring. The American journal of pathology. 2014. 184. 9. 2465-79
- Takuya Chiba, Yukari Tamashiro, Daeui Park, Tatsuya Kusudo, Ryoko Fujie, Toshimitsu Komatsu, Sang Eun Kim, Seongjoon Park, Hiroko Hayashi, Ryoichi Mori, et al. A key role for neuropeptide Y in lifespan extension and cancer suppression via dietary restriction. Scientific reports. 2014. 4. 4517-4517
- Xiaoping Sun, Toshimitsu Komatsu, Jinhwan Lim, Mara Laslo, Jason Yolitz, Cecilia Wang, Luc Poirier, Thomas Alberico, Sige Zou. Nutrient-dependent requirement for SOD1 in lifespan extension by protein restriction in Drosophila melanogaster. Aging cell. 2012. 11. 5. 783-93
- Takahiro Hayashida, Toshimitsu Komatsu, Yasuko Henmi, Kurumi Yanagihara-Ota, Ae-Ra Kim, Takuya Chiba, Shinji Goto, Hae Young Chung, Isao Shimokawa. Modest inhibition of the growth hormone axis does not affect mitochondrial reactive oxygen species generation or redox state, unlike calorie restriction. Geriatrics & gerontology international. 2011. 11. 4. 496-503
- 森 亮一, 間所 俊介, Kim Sang Eun, 小松 利光, 千葉 卓哉, 坪井 貴司, 下川 功. マクロファージからのサイトカイン分泌に関与する低分子量Gタンパク質Rabファミリーの機能解析. 基礎老化研究. 2011. 35. 3. 33-36
- 森 亮一, 間所 俊介, Kim Sang Eun, 小松 利光, 千葉 卓哉, 坪井 貴司, 下川 功. マクロファージのサイトカイン分泌に関与する低分子量G蛋白質Rab familyの機能解析. 基礎老化研究. 2011. 35. 2. 45-45
- Toshimitsu Komatsu, Lucas S Trindade, Takuya Chiba, Hiroko Hayashi, Tomoko Henmi, Yoko Ushiroda, Ryoichi Mori, Isao Shimokawa. Acute stress response modified by modest inhibition of growth hormone axis: a potential machinery of the anti-aging effect of calorie restriction. Mechanisms of ageing and development. 2011. 132. 3. 103-9
- Trindad Lucas Siqueira, Park Seong-Joon, Komatsu Toshimitsu, Yamaza Haruyoshi, Hayashi Hiroko, Mori Ryoichi, Chiba Takuya, Kuramoto Kazunao, Shimokawa Isao. Down-regulation of hepatic AMP-activated protein kinase and up-regulation of CREB coactivator CRTC2 for gluconeogenesis under calorie-restricted conditions at a young age. Acta Medica Nagasakiensia. 2011. 55. 2. 85-92
- Takuya Chiba, Tomoshi Tsuchiya, Toshimitsu Komatsu, Ryoichi Mori, Hiroko Hayashi, Isao Shimokawa. Development of calorie restriction mimetics as therapeutics for obesity, diabetes, inflammatory and neurodegenerative diseases. Current genomics. 2010. 11. 8. 562-7
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