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論文 (49件)
- Akiyoshi Nakayama, Yusuke Kawamura, Masahiro Nakatochi, Yu Toyoda, Mayuko Nakajima, Kazuki Maehara, Mana Kirihara, Seiko Shimizu, Keitaro Matsuo, Hirotaka Matsuo. Strong genetic effect on gout revealed by genetic risk score from meta-analysis of two genome-wide association studies. Human cell. 2024. 38. 1. 16-16
- Yusuke Kawamura, Akiyoshi Nakayama, Masahiro Nakatochi, Yuka Aoki, Yu Toyoda, Takahiro Nakamura, Seiko Shimizu, Keitaro Matsuo, Nariyoshi Shinomiya, Hirotaka Matsuo. Identification of novel gout loci from trans-ethnic meta-analysis of serum urate level. Human cell. 2024. 38. 1. 15-15
- 早野 貴美子, 中山 昌喜, 竹花 奈々, 三浦 美千瑠, 菊池 理園, 鳥羽 美帆, 清水 聖子, 上野 美紀, 松尾 洋孝. 尿酸輸送体遺伝子ABCG2変異による痛風・高尿酸血症の発症リスクの解析を通した、ゲノム個別化看護実装に向けての検討. 防衛衛生. 2023. 71. 別冊. 61-61
- 小倉 正恒, 豊田 優, 河村 優輔, 中山 昌喜, 高田 龍平, 清水 聖子, 東野 俊英, 中嶌 真由子, 四ノ宮 成祥, 松尾 洋孝, et al. APOE ε2ハプロタイプは血清尿酸値を増加させる. 痛風と尿酸・核酸. 2022. 46. 2. 168-168
- 豊田 優, 河村 優輔, 中山 昌喜, 東野 俊英, 清水 聖子, 大山 博司, 市田 公美, 四ノ宮 成祥, 高田 龍平, 松尾 洋孝, et al. URAT1遺伝子の機能低下型変異による痛風の保護効果は、ABCG2遺伝子の機能低下型変異による痛風のリスク亢進効果を上回る. 痛風と尿酸・核酸. 2022. 46. 2. 149-149
- Yu Toyoda, Akiyoshi Nakayama, Masahiro Nakatochi, Yusuke Kawamura, Hirofumi Nakaoka, Ken Yamamoto, Seiko Shimizu, Hiroshi Ooyama, Keiko Ooyama, Toru Shimizu, et al. Genome-wide meta-analysis between renal overload type and renal underexcretion type of clinically defined gout in Japanese populations. Molecular genetics and metabolism. 2022. 136. 3. 186-189
- Yuya Shirai, Akiyoshi Nakayama, Yusuke Kawamura, Yu Toyoda, Masahiro Nakatochi, Seiko Shimizu, Nariyoshi Shinomiya, Yukinori Okada, Hirotaka Matsuo. Coffee Consumption Reduces Gout Risk Independently of Serum Uric Acid Levels: Mendelian Randomization Analyses Across Ancestry Populations. ACR open rheumatology. 2022. 4. 6. 534-539
- Akiyoshi Nakayama, Yusuke Kawamura, Yu Toyoda, Seiko Shimizu, Makoto Kawaguchi, Yuka Aoki, Kenji Takeuchi, Rieko Okada, Yoko Kubo, Toshihiko Imakiire, et al. Genetic epidemiological analysis of hypouricaemia from 4993 Japanese on non-functional variants of URAT1/SLC22A12 gene. Rheumatology (Oxford, England). 2022. 61. 3. 1276-1281
- Shun-Jen Chang, Yu Toyoda, Yusuke Kawamura, Takahiro Nakamura, Masahiro Nakatochi, Akiyoshi Nakayama, Wei-Ting Liao, Seiko Shimizu, Tappei Takada, Kenji Takeuchi, et al. A meta-analysis of genome-wide association studies using Japanese and Taiwanese has revealed novel loci associated with gout susceptibility. Human cell. 2022. 35. 2. 767-770
- Yu Toyoda, Yusuke Kawamura, Akiyoshi Nakayama, Keito Morimoto, Seiko Shimizu, Yuki Tanahashi, Takashi Tamura, Takaaki Kondo, Yasufumi Kato, Kimiyoshi Ichida, et al. OAT10/SLC22A13 Acts as a Renal Urate Re-Absorber: Clinico-Genetic and Functional Analyses With Pharmacological Impacts. Frontiers in pharmacology. 2022. 13. 842717-842717
- 中山 昌喜, 中杤 昌弘, 河村 優輔, 清水 聖子, 東野 俊英, 清水 徹, 大山 恵子, 大山 博司, 長瀬 満夫, 日高 雄二, et al. ゲノムワイド関連解析による病型特異的な痛風関連遺伝子の同定と日本人の適応進化. 痛風と尿酸・核酸. 2021. 45. 2. 196-196
- 河村 優輔, 東野 俊英, 中山 昌喜, 清水 聖子, 四ノ宮 成祥, 高田 龍平, 松尾 洋孝, 豊田 優, 大西 卓磨, 久富 隆太郎, et al. 腎性低尿酸血症1型の新規病因変異である機能低下型スプライシング変異の同定 日本人2家系のURAT1/SLC22A12遺伝子の解析より. 痛風と尿酸・核酸. 2021. 45. 2. 214-214
- Yu Toyoda, Yusuke Kawamura, Akiyoshi Nakayama, Hirofumi Nakaoka, Toshihide Higashino, Seiko Shimizu, Hiroshi Ooyama, Keito Morimoto, Naohiro Uchida, Ryuichiro Shigesawa, et al. Substantial anti-gout effect conferred by common and rare dysfunctional variants of URAT1/SLC22A12. Rheumatology (Oxford, England). 2021. 60. 11. 5224-5232
- Masatsune Ogura, Yu Toyoda, Masayuki Sakiyama, Yusuke Kawamura, Akiyoshi Nakayama, Yoshihide Yamanashi, Tappei Takada, Seiko Shimizu, Toshihide Higashino, Mayuko Nakajima, et al. Increase of serum uric acid levels associated with APOE ε2 haplotype: a clinico-genetic investigation and in vivo approach. Human cell. 2021. 34. 6. 1727-1733
- Yusuke Kawamura, Akiyoshi Nakayama, Seiko Shimizu, Yu Toyoda, Yuichiro Nishida, Asahi Hishida, Sakurako Katsuura-Kamano, Kenichi Shibuya, Takashi Tamura, Makoto Kawaguchi, et al. A Proposal for Practical Diagnosis of Renal Hypouricemia: Evidenced from Genetic Studies of Nonfunctional Variants of URAT1/SLC22A12 among 30,685 Japanese Individuals. Biomedicines. 2021. 9. 8
- Makoto Kawaguchi, Akiyoshi Nakayama, Yuka Aoyagi, Takahiro Nakamura, Seiko Shimizu, Yusuke Kawamura, Mikiya Takao, Takashi Tamura, Asahi Hishida, Mako Nagayoshi, et al. Both variants of A1CF and BAZ1B genes are associated with gout susceptibility: a replication study and meta-analysis in a Japanese population. Human cell. 2021. 34. 2. 293-299
- Saki Takihata, Kunio Mizutari, Ichiro Morita, Hirotaka Matsuo, Akiyoshi Nakayama, Seiko Shimizu, Miki Ueno, Toshimitsu Ito, Nariyoshi Shinomiya, Akihiro Shiotani. The influence of a noisy environment on hearing impairment and tinnitus: The hearing outcomes of 50-year-old male Japan ground self-defense force personnel. Auris, nasus, larynx. 2020. 47. 6. 931-937
- Yusuke Kawamura, Yu Toyoda, Takuma Ohnishi, Ryutaro Hisatomi, Toshihide Higashino, Akiyoshi Nakayama, Seiko Shimizu, Masato Yanagi, Isamu Kamimaki, Rika Fujimaru, et al. Identification of a dysfunctional splicing mutation in the SLC22A12/URAT1 gene causing renal hypouricaemia type 1: a report on two families. Rheumatology (Oxford, England). 2020. 59. 12. 3988-3990
- Yu Toyoda, Tappei Takada, Hiroshi Miyata, Hirotaka Matsuo, Hidetoshi Kassai, Kazuki Nakao, Masahiro Nakatochi, Yusuke Kawamura, Seiko Shimizu, Nariyoshi Shinomiya, et al. Identification of GLUT12/SLC2A12 as a urate transporter that regulates the blood urate level in hyperuricemia model mice. Proceedings of the National Academy of Sciences of the United States of America. 2020. 117. 31. 18175-18177
- 赤司 藍理, 中山 昌喜, 東野 俊英, 清水 聖子, 河村 優輔, 川口 真, 高尾 幹也, 高田 龍平, 市田 公美, 大山 博司, et al. LDL receptor gene familyのひとつであるLRP2遺伝子の一塩基多型rs2544390は痛風発症と関連する 日本人男性におけるメタ解析. 痛風と尿酸・核酸. 2020. 44. 1. 87-87
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