| 詳細情報 |  |
|---|---|
| 関連リンク |  |
| 探す |  |
論文 (51件)
- Yu Miyajima, Tomomi Noguchi-Yachide, Kotaro Ochiai, Shinya Fujii. Physicochemical characterization of B-hydroxyphenyl phosphine borane derivatives and their evaluation as nuclear estrogen receptor ligands. RSC Medicinal Chemistry. 2023. 15. 1. 119-126
- Nao Namba, Tomomi Noguchi-Yachide, Yuichiro Matsumoto, Yuichi Hashimoto, Shinya Fujii. Design, synthesis and structure-activity relationship of 4-(1,1,1,3,3,3-hexafluoro-2-hydroxyisoprop-2-yl)phenylsilane derivatives as liver X receptor agonists. Bioorganic and Medicinal Chemistry. 2022. 66
- Ryuta Shioi, Fumika Karaki, Hiromasa Yoshioka, Tomomi Noguchi-Yachide, Minoru Ishikawa, Kosuke Dodo, Yuichi Hashimoto, Mikiko Sodeoka, Kenji Ohgane. Image-based screen capturing misfolding status of Niemann-Pick type C1 identifies potential candidates for chaperone drugs. PLoS ONE. 2020. 15. 12 December
- Shun Nanjyo, Kenji Ohgane, Hiromasa Yoshioka, Makoto Makishima, Yuichi Hashimoto, Tomomi Noguchi-Yachide. Structure-activity relationship study of estrogen receptor down-regulators with a diphenylmethane skeleton. Bioorganic and Medicinal Chemistry. 2019. 27. 10. 1952-1961
- Tomomi Noguchi-Yachide. Regulators of Histone Acetylation: Bromodomain Inhibitors. Pharmacoepigenetics. 2019. 463-473
- Ryo Eto, Takashi Misawa, Tomomi Noguchi-Yachide, Nobumichi Ohoka, Masaaki Kurihara, Mikihiko Naito, Masakazu Tanaka, Yosuke Demizu. Design and synthesis of estrogen receptor ligands with a 4-heterocycle-4-phenylheptane skeleton. Bioorganic and Medicinal Chemistry. 2018. 26. 8. 1638-1642
- Ryuta Shioi, Yosuke Toyota, Tomomi Noguchi-Yachide, Minoru Ishikawa, Takao Yamaguchi, Makoto Makishima, Yuichi Hashimoto, Kenji Ohgane. Unexpected emergence of luciferase-inhibitory activity during structural development study of phenyloxadiazole-based PPAR ligands. Heterocycles. 2018. 97. 2. 854-864
- Hiromitsu Fukuda, Fumika Karaki, Kosuke Dodo, Tomomi Noguchi-Yachide, Minoru Ishikawa, Yuichi Hashimoto, Kenji Ohgane. Phenanthridin-6-one derivatives as the first class of non-steroidal pharmacological chaperones for Niemann-Pick disease type C1 protein. Bioorganic and Medicinal Chemistry Letters. 2017. 27. 12. 2781-2787
- Seika Amemiya, Takao Yamaguchi, Yuichi Hashimoto, Tomomi Noguchi-Yachide. Synthesis and evaluation of novel dual BRD4/HDAC inhibitors. Bioorganic and Medicinal Chemistry. 2017. 25. 14. 3677-3684
- Ryuta Shioi, Shogo Okazaki, Tomomi Noguchi-Yachide, Minoru Ishikawa, Makoto Makishima, Yuichi Hashimoto, Takao Yamaguchi. Switching subtype-selectivity: Fragment replacement strategy affords novel class of peroxisome proliferator-activated receptor α/δ (PPARα/δ) dual agonists. Bioorganic and Medicinal Chemistry Letters. 2017. 27. 14. 3131-3134
- Seika Amemiya, Takao Yamaguchi, Yuichi Hashimoto, Tomomi Noguchi-Yachide. Development of N6-(Heteroarylcarbonyl) adenines as BRD4 inhibitors. Heterocycles. 2017. 94. 6. 1107-1114
- Seika Amemiya, Takao Yamaguchi, Taki Sakai, Yuichi Hashimoto, Tomomi Noguchi-Yachide. Structure-activity relationship study of N N6-benzoyladenine-type BRD4 inhibitors and their effects on cell differentiation and TNF-α production. Chemical and Pharmaceutical Bulletin. 2016. 64. 9. 1378-1383
- Shogo Okazaki, Tomomi Noguchi-Yachide, Taki Sakai, Minoru Ishikawa, Makoto Makishima, Yuichi Hashimoto, Takao Yamaguchi. Discovery of N-(1-(3-(4-phenoxyphenyl)-1,2,4-oxadiazol-5-yl)ethyl)acetamides as novel acetyl-CoA carboxylase 2 (ACC2) inhibitors with peroxisome proliferator-activated receptor α/δ (PPARα/δ) dual agonistic activity. Bioorganic and Medicinal Chemistry. 2016. 24. 21. 5258-5269
- Shogo Okazaki, Ryuta Shioi, Tomomi Noguchi-Yachide, Minoru Ishikawa, Makoto Makishima, Yuichi Hashimoto, Takao Yamaguchi. Structure-activity relationship studies of non-carboxylic acid peroxisome proliferator-activated receptor α/δ (PPARα/δ) dual agonists. Bioorganic and Medicinal Chemistry. 2016. 24. 21. 5455-5461
- Takashi Misawa, Momoko Yorioka, Yosuke Demizu, Tomomi Noguchi-Yachide, Nobumichi Ohoka, Megumi Kurashima-Kinoshita, Hitomi Motoyoshi, Hisao Nojiri, Atsushi Kittaka, Makoto Makishima, et al. Effects of alkyl side chains and terminal hydrophilicity on Vitamin D receptor (VDR) agonistic activity based on the diphenylpentane skeleton. Bioorganic and Medicinal Chemistry Letters. 2015. 25. 22. 5362-5366
- Tomomi Noguchi-Yachide, Taki Sakai, Yuichi Hashimoto, Takao Yamaguchi. Discovery and structure-activity relationship studies of N6-benzoyladenine derivatives as novel BRD4 inhibitors. Bioorganic and Medicinal Chemistry. 2015. 23. 5. 953-959
- Jun Ichi Yamaguchi, Tomomi Noguchi-Yachide, Yuka Sakaguchi, Chiaki Shibata, Shinnosuke Kanuma, Akiko Yoshizaki, Yuka Takizawa, Yuichi Hashimoto. Synthesis of new hydantoins bearing glutarimide or succinimide moiety and their evaluation for cell differentiation-inducing and anti-angiogenic activities. Heterocycles. 2015. 91. 4. 764-781
- Kenji Ohgane, Fumika Karaki, Tomomi Noguchi-Yachide, Kosuke Dodo, Yuichi Hashimoto. Structure-activity relationships of oxysterol-derived pharmacological chaperones for Niemann-Pick type C1 protein. Bioorganic and Medicinal Chemistry Letters. 2014. 24. 15. 3480-3485
- Yusuke Mita, Kosuke Dodo, Tomomi Noguchi-Yachide, Yuichi Hashimoto, Minoru Ishikawa. Structure-activity relationship of benzodiazepine derivatives as LXXLL peptide mimetics that inhibit the interaction of vitamin D receptor with coactivators. Bioorganic and Medicinal Chemistry. 2013. 21. 4. 993-1005
- Yusuke Mita, Tomomi Noguchi-Yachide, Minoru Ishikawa, Yuichi Hashimoto. Small-molecular, non-peptide, non-ATP-competitive polo-like kinase 1 (Plk1) inhibitors with a terphenyl skeleton. Bioorganic and Medicinal Chemistry. 2013. 21. 3. 608-617
前のページに戻る
