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J-GLOBAL ID：200901045905746199 Update date: Mar. 05, 2025

Tanaka Hiromitsu

タナカヒロミツ | Tanaka Hiromitsu

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Affiliation and department：
Job title： Associate Professor
Homepage URL (1)： https://www1.niu.ac.jp/about/teacher/detail.html?tid=189

Research field (8)： Genomics , Laboratory animal science , Urology , Pharmacology , Pharmaceuticals - health and biochemistry , Developmental biology , Molecular biology , Genetics

Research keywords (16)：がん , 幹細胞 , 減数分裂 , 精子形成 , 精細胞分化 , 半数体 , 生殖細胞 , 精巣 , spermiogenesis , Spermatogenesis , Experssion , Haploid , Germ , Testis , Gene , Histone

Research theme for competitive and other funds (30)：

2022 - 2025 Clinical significance of serum zinc for spermatogenesis and testosterone secretion
2021 - 2024 Study of HASPIN Kinase Inhibitors to Suppress Prostate Cancer
2017 - 2020 Study on mechanism of Notch signaling in testiculara germ cell and its clinical role in human
2016 - 2019 The analysis of function of the flavonoids which is active on the fertility rate of IVF.
2013 - 2016 Effective compounds for male infertility patients with reference data for a noninvasive genetic diagnosis

2012 - 2015 Identification and analysis of antigen for TRA98 which specifically recognizes germ cells

2011 - 2012 受精・発生を支える精子細胞特異的に発現する遺伝子の欠失マウスの解析

2010 - 2012 Exploitation of noninvasive genetic diagnosis for therapy of male infertility

2009 - 2010 受精・発生を支える精子細胞特異的に発現する遺伝子の欠失マウスの解析

2006 - 2008 Development of a novel diagnostic method for male infertility

2006 - 2007 初期発生を支える精子細胞クロマチン構造におけるエピジェネティクス

2005 - 2007 Development of diagnosis and treatment method of man sterility based on analyses of spermatogenesis-assaciatal genes

2004 - 2005 精子細胞分化・初期発生とエピジェネシス

2004 - 2005 精巣型アクチンキャッピング蛋白に関する研究

2003 - 2004 I Identification and characterization of genes and mechanism of human male infertility

2002 - 2003 Isolation and characterization of sperm associated genes

2000 - 2001 半数体精子細胞の分裂を調節するSer/Thrキナーゼ遺伝子haspinの解析

2000 - 2001 Effects of endocrine disrupter on haploid spermatids and heterozygous mice with germ cell deficiency

2000 - 2000 マウス半数体精子細胞特異的に発現する遺伝子群の解析

1999 - 1999 マウス半数体精子細胞特異的に発現する遺伝子群の解析

1999 - 1999 分子シャペロン-カルメジンの機能解析

1998 - 1999 ローカリゼーションシグナルトラップ法の開発と、細胞分化に関する遺伝子群の解析

1998 - 1998 マウス半数体精子細胞特異的に発現される遺伝子群の解析

1998 - 1998 分子シャペロン-カルメジンの機能解析

1997 - 1998 Cloning and Characterization of Genes Specifically Expressed in Haploid Germ Cells

1997 - 1998 The Mechanism of Sperm/egg interaction and involved factors.

1995 - 1995 生殖細胞の発生と分化に特異的発現をする遺伝子の解析

1995 - 1995 血管障害後の新生内膜肥厚におけるTGF-βと転写因子の発現に関する研究

精細胞の分化と遺伝子発現

Development and Gene Expression in Germ Cells

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Papers (174)：

Hiromitsu Tanaka, Shunsuke Matsuyama, Tomoe Ohta, Keisuke Kakazu, Kazutoshi Fujita, Shinichiro Fukuhara, Tetsuji Soda, Yasushi Miyagawa, Akira Tsujimura. The Natural HASPIN Inhibitor Coumestrol Suppresses Intestinal Polyp Development, Cachexia, and Hypogonadism in a Mouse Model of Familial Adenomatous Polyposis (ApcMin/+). Biology. 2024. 13. 9
Hiromitsu Tanaka, Keizo Tokuhiro. A Haspin promoter element induces tissue-specific methylation of a transcription region and the regulation of gene expression in mouse ova. Cell journal. 2022. 24. 9. 552-554
Hiromitsu Tanaka, Hisayo Nishida-Fukuda, Morimasa Wada, Keizo Tokuhiro, Hiroaki Matsushita, Yukio Ando. Inhibitory Effect of the HASPIN Inhibitor CHR-6494 on BxPC-3-Luc, A Luciferase-Expressing Pancreatic Cancer Cell Line. Cell journal. 2022. 24. 4. 212-214
Tomoe Ohta, Takuhiro Uto, Yukihiro Shoyama, Maxwell Mamfe Sakyiamah, Alfred Ampomah Appiah, Hiromitsu Tanaka. In vitro fertilization using sperm activated by ML-2-3 isolated from Morinda lucida Bentham leaves. Reproductive Medicine and Biology. 2022. 21. 1
Takafumi Matsumura, Takuya Sato, Takeru Abe, Hiroyuki Sanjo, Kumiko Katagiri, Hiroshi Kimura, Teruo Fujii, Hiromitsu Tanaka, Masumi Hirabayashi, Takehiko Ogawa. Rat in vitro spermatogenesis promoted by chemical supplementations and oxygen-tension control. Scientific Reports. 2021. 11. 1

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MISC (76)：

Hiromitsu Tanaka, Akira Tsujimura. Pervasiveness of intronless genes expressed in haploid germ cell differentiation. Reproductive Medicine and Biology. 2021. 20. 3. 255-259
田中宏光, 福田枝里子, 山口圭, 高坂美恵子, 河村義史, 奥田英伸, 磯谷綾子, 伊川正人, SMITH Shapiro Virginia, 土田順司, et al. 生殖細胞を特異的に認識するモノクローナル抗体TRA98の抗原同定とその機能の解析. 日本アンドロロジー学会総会記事. 2021. 40th
宮川康, 福原慎一郎, 藤田和利, 木内寛, 田中宏光, 辻村晃. 精子を知る,見る,作る精子研究の臨床応用. 日本生殖医学会雑誌. 2018. 63. 3. 240-240
Tanaka H, Wada M, Tung HN, Fujii S, Uto T, Shoyama Y. In Vitro Fertilization Activators for Future. Biological Activities and Action Mechanisms of Licorice Ingredients. 2017
正山征洋, 田中宏光. 「甘草の神秘~人口減少時代の到来に向けての福音~」. 自費出版. 2017

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Patents (16)：

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Professional career (1)：

博士(薬学) (京都薬科大学)

Awards (3)：

1999 - 2. Poster Award of the XVth Testis workshop, 1999
1997 - Congress of Androgy, 1997
1900 - 1. Poster Award of The Jury of the sixth International

Association Membership(s) (6)：

日本失疾モデル学会 , 日本発生生物学会 , 日本分子生物学会 , Japanese Society of Animal Models for Human Diseases , Japanese Society of Developmental Biology , Japanese Society of Molecular Biology

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