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J-GLOBAL ID：200901046764938117 Update date: Apr. 10, 2025

Takeshima Tsuguhide

タケシマツグヒデ | Takeshima Tsuguhide

Affiliation and department：

Research field (4)： Tumor diagnostics and therapeutics , Cell biology , Immunology , Radiology

Research keywords (4)：放射線治療 , 腫瘍免疫 , 免疫治療 , 放射線生物学

Research theme for competitive and other funds (7)：

2022 - 2025 同所移植モデルによる難治性腫瘍免疫応答を誘導する免疫療法と放射線の併用戦略の検討
2019 - 2022 Improvement of conventional adoptive cell therapy for cancer utilized tumor-specific immune responses induced by radiation therapy
2019 - 2022 Quantitative evaluation of radiation-induced immunostimulating effect
2018 - 2019 放射線がん治療後に誘導される抗腫瘍免疫応答を利用した新規がん治療法の開発
2012 - 2015 がん細胞は自身の生存をかけ放射線域を逃れるべく上皮間葉移行をなしうるか

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Papers (33)：

Kazutaka Doi, Makoto Shinoto, Tetsuro Isozaki, Takashi Imai, Toshiki Aiba, Sumitaka Hasegawa, Tsuguhide Takeshima. Prognostic Significance of Plasma Soluble IL-6 Receptor in Carbon-ion Radiotherapy for Pancreatic Cancer. Anticancer Research. 2025. 45. 1. 209-217
Tsuguhide Takeshima, Sumitaka Hasegawa. Restoration of thymic T-cell development by bone marrow transplantation in mouse radiation lymphomagenesis. Journal of radiation research. 2024
Tsuguhide Takeshima, Ryoichi Hirayama, Sumitaka Hasegawa. Experimental evidence that carbon-ion radiotherapy utilizes cytotoxic T lymphocyte-mediated anti-tumor immunity for shrinking tumors compared to X-ray therapy. Biochemical and biophysical research communications. 2024. 718. 150058-150058
Liqiu Ma, Yoshimitsu Sakamoto, Ken Ando, Hidetoshi Fujita, Akihisa Takahashi, Tsuguhide Takeshima, Hiromi Otsuka, Daniel K Ebner, Kazuhiro Kakimi, Takashi Imai, et al. Th Balance-Related Host Genetic Background Affects the Therapeutic Effects of Combining Carbon-Ion Radiation Therapy With Dendritic Cell Immunotherapy. International journal of radiation oncology, biology, physics. 2022. 112. 3. 780-789
Tsuguhide Takeshima. Selective Targeting of Cancerous Mitochondria and Suppression of Tumor Growth Using Redox-Active Treatment Adjuvant. Oxidative Medicine and Cellular Longevity. 2020. 2020. 1-30

MISC (2)：

西岡健, 安田元昭, 武島嗣英, 芳賀永, 宮井優介, 柴田健一郎, 山崎理衣, 白土博樹, 手塚正博, 伊達広行. 放射線により誘発されるがん細胞の再増殖 : 移植可能なマウス肉腫細胞を用いた実験から類推されるメカニズム. 北海道醫學雜誌 = Acta medica Hokkaidonensia. 2012. 87. 4. 192-192
T. Nishioka, K. Tsutsumi, T. Takeshima, H. Shirato, M. Yasuda. Matrix Metalloproteinase's Are Up-regulated in Sub-clones That Survived 10Gy Irradiation: A Possible Role of Hypoxic-inducible Factor-alpha (HIF1a). INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS. 2010. 78. 3. S631-S631

Patents (2)：

Education (3)：

Professional career (1)：

Work history (9)：

2018 - 現在 National Institutes for Quantum and Radiological Science and Technology
2017 - 2018 National Institutes for Quantum and Radiological Science and Technology
2013 - 2017 米国テキサス大学サウスウエスタン医学センター Instructor
2011 - 2013 米国テキサス大学サウスウエスタン医学センター Assistant Instructor
2008 - 2011 Hokkaido University Graduate School of Medicine

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