Tsuzuki Teruhisa

ツヅキテルヒサ | Tsuzuki Teruhisa

Affiliation and department：
Job title： Professor
Homepage URL (2)： http://hyoka.ofc.kyushu-u.ac.jp/search/details/K002228/index.html , http://www.med.kyushu-u.ac.jp/biophys/

Research field (4)： Molecular biology , Environmental effects of chemicals , Environmental effects of radiation , Laboratory animal science

Research keywords (5)：分子腫瘍学 , 環境影響評価(含放射線生物学) , 分子遺伝学 , Environmental Influence Assessment (including Radiobiology) , Molecular Genetics

Research theme for competitive and other funds (16)：

2013 - 2017 ゲノム損傷応答系の不全による変異誘発と発がんに関する研究
2010 - 2013 疾患モデル動物を用いた環境発がんの初期過程の分子機構および感受性要因の解明とその臨床応用に関する研究
2009 - 2011 食品添加物等における遺伝毒性発がん物質の評価法に関する研究
2008 - 2010 DNA修復系遺伝子欠損マウスを用いた変異原性・発がん性の高感度評価系の開発
2006 - 2009 酸化ストレス誘発発がんの抑制に関与する分子機構の解明

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Papers (16)：

Mizuki Ohno, Kunihiko Sakumi, Ryutaro Fukumura, Masato Furuichi, Yuki Iwasaki, Masaaki Hokama, Toshimichi Ikemura, Teruhisa Tsuzuki, Yoichi Gondo, Yusaku Nakabeppu. 8-oxoguanine causes spontaneous de novo germline mutations in mice. SCIENTIFIC REPORTS. 2014. 4
Jingshu Piao, Yoshimichi Nakatsu, Mizuki Ohno, Ken-ichi Taguchi, Teruhisa Tsuzuki. Mismatch Repair Deficient Mice Show Susceptibility to Oxidative Stress-Induced Intestinal Carcinogenesis. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES. 2014. 10. 1. 73-79
Takuro Isoda, Yoshimichi Nakatsu, Kazumi Yamauchi, Jingshu Piao, Takashi Yao, Hiroshi Honda, Yusaku Nakabeppu, Teruhisa Tsuzuki. Abnormality in Wnt Signaling is Causatively Associated with Oxidative Stress-Induced Intestinal Tumorigenesis in MUTYH-Null Mice. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES. 2014. 10. 8. 940-947
Teik How Lim, Ryosuke Fujikane, Shiori Sano, Ryuji Sakagami, Yoshimichi Nakatsu, Teruhisa Tsuzuki, Mutsuo Sekiguchi, Masumi Hidaka. Activation of AMP-activated protein kinase by MAPO1 and FLCN induces apoptosis triggered by alkylated base mismatch in DNA. DNA REPAIR. 2012. 11. 3. 259-266
Teik How Lim, Ryosuke Fujikane, Shiori Sano, Ryuji Sakagami, Yoshimichi Nakatsu, Teruhisa Tsuzuki, Mutsuo Sekiguchi, Masumi Hidaka. Activation of AMP-activated protein kinase by MAPO1 and FLCN induces apoptosis triggered by alkylated base mismatch in DNA. DNA REPAIR. 2012. 11. 3. 259-266

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MISC (89)：

Tsuzuki, T, Piao, J, Isoda, T, Sakumi, K, Nakabeppu, Y, Nakatsu, Y. Oxidative stress-induced tumorigenesis in the small intestine of various types of DNA repair-deficient mice. Health Physics. 2011. 100. 3. 293-294
Hiroyuki Kamiya, Masayuki Uchiyama, Yoshimichi Nakatsu, Teruhisa Tsuzuki, Hideyoshi Harashima. Effects of target sequence and sense versus anti-sense strands on gene correction with single-stranded DNA fragments. JOURNAL OF BIOCHEMISTRY. 2008. 144. 4. 431-436
Hiroyuki Tsuchiya, Masayuki Uchiyarna, Kazuhiro Hara, Yoshimichi Nakatsu, Teruhisa Tsuzuki, Hideo Inoue, Hideyoshi Harashima, Hiroyuki Kamiya. Improved gene correction efficiency with a tailed duplex DNA fragment. BIOCHEMISTRY. 2008. 47. 33. 8754-8759
Masayuki Sanada, Masumi Hidaka, Yasumitsu Takagi, Tomoko Y. Takano, Yoshimichi Nakatsu, Teruhisa Tsuzuki, Mutsuo Sekiguchi. Modes of actions of two types of anti-neoplastic drugs, dacarbazine and ACNU, to induce apoptosis. CARCINOGENESIS. 2007. 28. 12. 2657-2663
Katsumi Sakamoto, Yohei Tominaga, Kazumi Yamauchi, Yoshimichi Nakatsu, Kunihiko Sakumi, Kaoru Yoshiyama, Akinori Egashira, Shinobu Kura, Takashi Yao, Masazumi Tsuneyoshi, et al. MUTYH-null mice are susceptible to spontaneous and oxidative stress-induced intestinal tumorigenesis. CANCER RESEARCH. 2007. 67. 14. 6599-6604

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Patents (2)：

Bacteriophage Vectors Generated by Bacteriophage/Plasmid Recombination
Bacteriophage Vectors Generated by Bacteriophage/Plasmid Recombination

Books (7)：

Oxidative DNA damege-induced intestinal tumorigenesis
2015
「放射線医科学 -生体と放射線・電磁波・超音波-(監修大西武雄)」第2章 2.8 放射線による発がん
学会出版センター 2007
DNA修復酵素遺伝子-2-酸化的DNA損傷の防止・修復系を中心として-(共著)
モデル動物の作製と維持(単行本)[(株)エル・アイ・シー] 2004
Spontaneous tumorigenesis and mutagenesis in mice defective in the <i>MTH1</i> gene encoding 8-oxo-dGTPase.
International Congress Series 2002
酸化的損傷ヌクレオチドにより誘発される変異の防御システム
別冊医学のあゆみ酸化ストレス-フリーラジカル医学生物学の最前線 2001

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Lectures and oral presentations (15)：

Oxidative stress-induced intestinal tumors in Mutyh-deficient mice treated with low doses of potassium bromate.
(4th Asian Conference on Environmental Mutagen 2014)
Oxidative stress-induced intestinal tumors in Mutyh-deficient mice treated with low doses of potassium bromate.
(5th US-Japan DNA Repair Meeting 2014)
Current Issues of Radiation Risk Education in Japanese Universtities, especially Medical Schools
(FMU-IAEA International Academic Conference, Radiation, Health, and Society: Post-Fukushima Implications for Health Professional Education 2013)
Oxidative stress-induced tumorigenesis in the small intestines of Mutyh-deficient mice: the effect of low-level exposure to KBrO3
(11th International Conference on Environmental Mutagens 2013)
Oxidative stress-induced tumorigenesis in the small intestine of Mutyh-deficient mice: the effect of low-level exposure to KBrO3
(2013)

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Works (5)：

発がん性予測候補遺伝子セットの生物学的解析
2005 -
放射線によるゲノム荷重回避の分子制御機構
1999 -
Radiation Induced DNA Damage and Its Defence Mechanism
1999 -
標的遺伝子組換えの迅速・簡便法の開発
1996 -
Exploiting Bacteriophage Genetics for High Throughput Functional Genomics
1996 -

Education (4)：

- 1981 Kyushu University
- 1981 Kyushu University Graduate School of Science, Biology(Molecular Genetics)
- 1975 Kyushu University School of Sciences
- 1975 Kyushu University Faculty of Science

Professional career (2)：

Doctor of Science (Kyushu University)
Master of Science (Kyushu University)

Work history (13)：

2017/04 - 2019/03 Fukuoka Dental College Advanced Science Research Center Guest Professor
2000/02 - 2017/03 - 九州大学大学院医学研究院教授
2007 - - 九州大学医学部生命科学科長
2007 - - Department of Biomedical Science, School of Medicine, Kyushu University, Head
1998 - 2000 Kyushu University School of Medicine

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Committee career (16)：

2017/10 - 現在日本学術会議連携会員, 環境リスク分科会
2017/10 - 現在日本学術会議連携会員, ICLAS分科会幹事
2017/10 - 現在日本学術会議連携会員, 放射線防護・リスクマネジメント分科会副委員長
2011/10 - 現在日本学術会議連携会員, ICLAS分科会委員
2012/01 - 2019/12 日本環境変異原学会評議員

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Awards (2)：

2017/11 - The Japanese Environmental Mutagen Society JEMS Award
2014/05 - Asian Association for Radiation Research AARR Award (Medicine) Prevention of Oxidative Tumorigenesis by DNA Repair Enzymes: Implication in Human Cancer

Association Membership(s) (8)：

日本環境変異原学会 , 日本放射線影響学会 , アメリカ癌学会(American Association for Cancer Research) , 日本癌学会 , 日本分子生物学会 , American Association for the Advancement of Science , American Society for Microbiology , American Association for Cancer Research

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