Ariga Sanae

Affiliation and department：
Job title： Professor, Vice-Executive
Homepage URL (1)： http://www.agr.hokudai.ac.jp/emolb/

Research field (5)： Medical biochemistry , Molecular biology , Cell biology , Applied molecular and cellular biology , Neuroscience - general

Research keywords (24)： PARK7 , protooncogenes , SUMO-1 , spermatogenesis , hsp70 , tyrosine hydroxylase , neurodegenerative diseases , oxidation , MM-1 , protease , Pim-1 , transcriptional regulation , transcription factor , reactive oxygen species (ROS) , oxidative stress , Parkinson's disease , mitochondria , apoptosis , cell cycle , tumor suppressor genes , DNA replication , DJ-1 , oncogenes , c-myc

Research theme for competitive and other funds (38)：

2012 - 2014 DJ-1結合化合物による神経変性疾患根本的治療薬の開発
2011 - 2013 DJ-1の酸化修飾によるシグナル変動とパーキンソン病、細胞癌化
2010 - 2012 Pathogenic mechanisms of Parkinson's disease via DJ-1 and targeted drug development
2008 - 2009 パーキンソン病PARK7の原因遺伝子DJ-1の機能解析
2006 - 2007 網膜性色素変性症RP9の原因遺伝子PAP-1の機能と治療薬の確立

2006 - 2007 Function of DJ-1, a causative gene for familial Parkinson's disease PARK7

2006 - 2007 Function of DJ-1, a causative gene for familial Parkinson's disease PARK7 and oncogene

2006 - 2007 パーキンソン病PARK7の原因遺伝子DJ-1の機能解析

2005 - 2005 パーキンソン病PARK7の原因遺伝子DJ-1の機能解析

2004 - 2005 内分泌かく乱物質による精子形成不全と協調するタンパク質DJ-1

2004 - 2005 Function of DJ-1, a causative gene for familial Parkinson's disease PARK7

2004 - 2004 パーキンソン病PARK7の原因遺伝子DJ-1の構造と機能

2003 - 2003 新規c-Myc結合タンパク質MM-1のがん抑制遺伝子産物としての機能

2002 - 2003 内分泌かく乱物質による精子形成不全と協調するタンパク質DJ-1

2002 - 2003 Functions of Myc and c-Myc-binding proteins

2002 - 2003 Function of PAP-1,a causative gene for retinitis pigmentosa

2002 - 2003 内分泌攪乱物質のターゲットタンパク質DJ-1の機能解析

2002 - 2002 新規c-Myc結合タンパク質MM-1のがん抑制遺伝子産物としての機能

2001 - 2001 内分泌かく乱物質による精子形成不全と協調するタンパク質DJ-1

2001 - 2001 新規C-Myc結合タンパク質MM-1がん抑制遺伝子産物としての機能

2000 - 2001 Regulation of cell-cycle movement and cell transformation by c-Myc and its binding proteins

2000 - 2000 新規c-Myc結合タンパク質MM-1のがん抑制遺伝子産物としての機能

1998 - 1999 Regulation of cell-cycle movement and cell transformation by nuclear oncogenes.

1998 - 1999 Mechanism of Functional Switching of C-MYC: Formation of Different Protein Complexes and Expression of Activities in DNA Replication, Transcription and Apoptosis Induction during the Cell Cycle.

1996 - 1997 Molecular mechanism of cell proliferation and appoptosis by the actions of transcription/replication factors in mammalian cells.

1995 - 1997 Establishment of gene therapy vector by using DNA replication origin and virus vector

1995 - 1997 MOLECULAR MECHANISMS OF THE CELL CYCLE REGULATION BY REPLICATION/TRANSCRIPTION FACTORS,MSSP

1996 - 1996 転写・複製因子MYCとその結合タンパク質による細胞周期と細胞死の調節

1995 - 1995 転写・複製因子mycタンパク質による細胞周期と細胞死の調節

1994 - 1994 mycタンパク質によるDNA複製開始、転写、細胞死の分子機構

1994 - 1994 神経細胞死とmyc

1993 - 1993 核内癌遺伝子産物によるDNA複製開始と転写の調節機構

1993 - 1993 ヒト熱ショックタンパク質70(HSP70)遺伝子の発現調節と産物タンパク質の機能

1992 - 1993 Construction of expression vectors using initiation sites of DNA replication and their application to gene therapy

1991 - 1993 Function of lipid transfer protein and its homologus proteins in plant cells

1991 - 1992 Concerted mechanism of DNA replication initiation and transcription in mammalian cells

1990 - 1990 細胞性癌遺伝子mycタンパク質の機能と細胞内情報伝達系における役割

1987 - 1987 DNA複製開始部位とDNA複製タンパクとの相互作用

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Papers (75)：

Kentaro Ozawa, Hiroki Tsumoto, Yuri Miura, Junji Yamaguchi, Sanae M M Iguchi-Ariga, Tetsushi Sakuma, Takashi Yamamoto, Yasuo Uchiyama. DJ-1 is indispensable for the S-nitrosylation of Parkin, which maintains function of mitochondria. Scientific reports. 2020. 10. 1. 4377-4377
Takeshi Niki, Jinro Endo, Kazuko Takahashi-Niki, Tatsuki Yasuda, Asami Okamoto, Yoshiro Saito, Hiroyoshi Ariga, Sanae M M Iguchi-Ariga. DJ-1-binding compound B enhances Nrf2 activity through the PI3-kinase-Akt pathway by DJ-1-dependent inactivation of PTEN. Brain research. 2020. 1729. 146641-146641
Tatsuki Yasuda, Takeshi Niki, Hiroyoshi Ariga, Sanae M M Iguchi-Ariga. Free radicals impair the anti-oxidative stress activity of DJ-1 through the formation of SDS-resistant dimer. Free radical research. 2017. 51. 4. 397-412
Hiroyoshi Ariga, Sanae M M Iguchi-Ariga. Introduction/Overview. Advances in experimental medicine and biology. 2017. 1037. 1-4
Kazuko Takahashi-Niki, Takeshi Niki, Sanae M M Iguchi-Ariga, Hiroyoshi Ariga. Transcriptional Regulation of DJ-1. Advances in experimental medicine and biology. 2017. 1037. 89-95

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MISC (29)：

Dysfunction of the anti-oxidative stress system and Parkinson's disease. 2010. 232. 6. 691-696
Shizuma Ishikawa, Takahiro Taira, Kazuko Takahashi-Niki, Takeshi Niki, Hiroyoshi Ariga, Sanae M. M. Iguchi-Ariga. Human DJ-1-specific transcriptional activation of the tyrosine hydroxylase gene. NEUROSCIENCE RESEARCH. 2010. 68. E305-E306
Izumi Kato, Hiroshi Maita, Sanae M. M. Iguchi-Ariga, Hiroyoshi Ariga. Oxidative status of DJ-1-dependent regulation of the p53 signaling. NEUROSCIENCE RESEARCH. 2010. 68. E307-E307
Function of DJ-1 as an anti-oxidative stress factor and Parkinson's disease. 2008. 225. 5. 445-449
IGUCHI ARIGA SANAE M. M., SANAE M.M. IGUCHI-ARIGA, Support Office for Female Researchers:Graduate School of Agriculture Hokkaido University. Aspects and perspective of female researchers in Hokkaido University(Aspects and perspective of female researchers in the field of fisheries sciences,Mini-Symposium). NSUGAF. 2008. 74. 2. 273-274

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Professional career (1)：

Work history (17)：

2010 - 北海道大学 (連合)農学研究科(研究院) 教授
2007 - 2008 北海道大学大学院・農学研究院教授
2004 - 2007 北海道大学 (連合)農学研究科(研究院) 教授
2007 - 北海道大学大学院・農学研究科教授
2007 - 北海道大学大学院医学研究科・教授

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Awards (1)：

2009/12 - National Institute of Science and Technology Policy Distinguished Contribution to Science and Technology 2009 (Nice Step Researcher) Environmental improvement and promotion of recruiting female researchers for women’s participation and advancement in science and technology

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