Rchr
J-GLOBAL ID：200901050726079892
Update date: Sep. 19, 2024
Dairi Tohru
ダイリ トオル | Dairi Tohru
Affiliation and department：
Job title：
Professor
Homepage URL (1)：
https://www.eng.hokudai.ac.jp/labo/tre/ABCLab_jp/
Research field (2)：
Applied microbiology
, Bioorganic chemistry
Research keywords (3)：
生合成
, 天然物
, Natural product biosynthesis
Research theme for competitive and other funds (29)：
- 2022 - 2027 Dissecting biosynthetic machineries of natural peptides leading to structural and functional diversities.
- 2018 - 2022 Dissecting reaction mechanisms of novel peptide epimerases
- 2016 - 2021 Redesigning Biosynthetic Machineries (Project Team)
- 2016 - 2021 Studies on biosynthetic machinery of biologically active natural products
- 2016 - 2021 Redesigning Biosynthetic Machineries (International Activity Support Team)
- 2015 - 2018 Biosynthesis of the Carbonylmethylene Structure Found in a Class of Pseudotripeptides, Ketomemicins
- 2010 - 2016 Biosynthetic machinery: Deciphering and regulating the system for creating structural diversity of baioactive metabolites
- 2013 - 2015 Peptide synthesis cooperatively achieved by peptide ligase and ribosomes
- 2011 - 2015 Studies on biosynthetic machineries for cyclic terpenoids and nucleoside antibiotics
- 2012 - 2014 Study on a novel folate biosynthesis pathway on micoorganism
- 2012 - 2012 Estimation of an alternative biosynthetic pathway for co-factors by close investigation of genome databases.
- 2010 - 2012 Screening of natural products which inhibits a new menaquinone biosynthetic pathway
- 2011 - 2011 微生物が生産する環状テルペノイド生合成マシナリーの解明と再構築
- 2008 - 2009 病原菌が持つメナキノン新規生合成経路の全容解明と経路特異的阻害剤の探索
- 2007 - 2009 Studies on diterpene cyclases found in eubacteria
- 2006 - 2007 病原菌が持つメナキノン新規生合成経路の全容解明と経路特異的阻害剤の探索
- 2005 - 2007 Studies on a new biosynthetic pathway for menaquinone (vitamin K)
- 2004 - 2006 Studies on production and improvement of terpenoids using biosynthetic gene cluster in fungi and plants.
- 2004 - 2006 Studies on isoprenoid biosynthetic genes isolated from prokaryotes
- 2002 - 2003 Studies on diterpene cydases found in actinomycetes.
- 2001 - 2003 Scientific research on elucidation of terpene-cyclic reactions in the biosynthesis of bioactive microbial terpenoids.
- 2000 - 2001 Studies on the biosynthesis of terpenoids produced by streptomycetes.
- 1996 - 1998 Cloning and Analysis of Tautomycin Biosynthetic Genes
- 1996 - 1997 Reaction Mechanisms and Application of New Bacterial Enzymes
- 1995 - 1996 Development of Novel Lyases and Their Application to the Synthesis of Optically Active Compounds
- 1996 - Studies on biosynthesis of terpenoids produced by microorganisms
- 1994 - Studies on antibiotic biosynthesis
- Studies on biosynthesis of natural product
- Studies on biosynthetic genes and enzymes of isoprenoids produced by microorganisms
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Papers (149)：
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Ning Shen, Yasuharu Satoh, Daisuke Koma, Hiroyuki Ohashi, Yasushi Ogasawara, Tohru Dairi. Optimization of tyrosol-producing pathway with tyrosine decarboxylase and tyramine oxidase in high-tyrosine-producing Escherichia coli. Journal of Bioscience and Bioengineering. 2024. 137. 2. 115-123
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Shuhei Umetsu, Takeshi Tsunoda, Haruka Kiyanagi, Yuki Inahashi, Kenichi Nonaka, Tohru Dairi, Yasushi Ogasawara. Identification of a new oligomycin derivative as a specific inhibitor of the alternative peptidoglycan biosynthetic pathway. The Journal of antibiotics. 2024
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Hinata Kato, Moeka Sakuta, Takeshi Tsunoda, Yu Nakashima, Hiroyuki Morita, Yasushi Ogasawara, Tohru Dairi. Peptide Epimerase Responsible for d-Amino Acid Introduction in Poly-γ-glutamic Acid Biosynthesis. Biomacromolecules. 2023. 25. 1. 349-354
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Yu Nakashima, Atsushi Kawakami, Yasushi Ogasawara, Masatoshi Maeki, Manabu Tokeshi, Tohru Dairi, Hiroyuki Morita. Structure of lasso peptide epimerase MslH reveals metal-dependent acid/base catalytic mechanism. Nature Communications. 2023. 14. 1
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Wanlu Xiao, Takeshi Tsunoda, Chitose Maruyama, Yoshimitsu Hamano, Yasushi Ogasawara, Tohru Dairi. Peptide epimerase-dehydratase complex responsible for biosynthesis of the linaridin class ribosomal peptides. Bioscience, biotechnology, and biochemistry. 2023. 87. 11. 1316-1322
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MISC (149)：
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SHEN Ning, SATOH Yasuharu, OGASAWARA Yasushi, DAIRI Tohru. Bioprocess for tyrosol production with bacterial phenylalanine hydroxylase. 日本栄養・食糧学会北海道支部大会講演要旨集. 2023. 53rd (CD-ROM)
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SHEN Ning, SATOH Yasuharu, KOMA Daisuke, OGASAWARA Yasushi, DAIRI Tohru. Engineering Escherichia coli for high production of tyrosol from phenylalanine. 日本生物工学会大会講演要旨集. 2023. 75th
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梅津秀平, 角田毅, 稲橋佑起, 野中健一, 小笠原泰志, 大利徹. Searching for Specific Inhibitors of the Alternative Pathway of Peptidoglycan Biosynthesis. 日本放線菌学会大会講演要旨集. 2023. 37th
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高橋佑大, 中川陽, 角田毅, 大利徹, 小笠原泰志. Biosynthetic Studies on Antitumor Antibiotic Mitomycins. 日本放線菌学会大会講演要旨集. 2023. 37th
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角田毅, 古村淳吉, 山崎陽香, 小笠原泰志, 大利徹. Biosynthetic studies on natural product containing α,α-disubstituted amino acid. 日本放線菌学会大会講演要旨集. 2023. 37th
ｍore...
Patents (9)：
Books (2)：
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Isoprenoid Synthesis in Plants and Microorganisms
2013
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Comprehensive Natural Products II Chemistry and BiologyMander, L., Lui, H.-W., Eds.volume 1, pp. 789-814.
2010
Education (4)：
- - 1985 Nagoya University
- - 1985 Nagoya University Graduate School, Division of Agriculture
- - 1983 Nagoya University School of Agricultural Sciences
- - 1983 Nagoya University Faculty of Agriculture
Professional career (1)：
Work history (5)：
- 2010/04 - 現在 Hokkaido University Faculty of Engineering
- 1994/04 - 2010/03 Toyama Prefectural University
- 1994/04 - 2010/03 - Biotechnology Research Center, Toyama Prefectural University
- 1985 - 1994 協和発酵工業(株)東京研究所
- 1985 - 1994 Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.
Committee career (7)：
Awards (18)：
- 2023/03 - Japan Society for Bioscience, Biotechnology, and Agrochemistry (JSBBA) JSBBA Award Studies on biosynthetic enzymes leading structural and functional diversities to microbial natural products.
- 2022/03 - 日本農芸化学会 トピックス賞 微細藻類由来DHA合成酵素の炭素鎖伸長反応の解析
- 2021/03 - 日本農芸化学会 トピックス賞 ポリグルタミン酸生合成におけるエピメリ化酵素の同定
- 2019/03 - 日本農芸化学会 トピックス賞 in vitro解析による多価不飽和脂肪酸生合成酵素の炭素鎖長制御機構の解明
- 2017/03 - 日本農芸化学会 トピックス賞 An unprecedented glutamate epimerase for bacterial peptidoglycan biosynthesis
- 2015/06 - 日本生物工学会 第23回生物工学論文賞 New gene responsible for para-aminobenzoate biosynthesis
- 2012 - 酵素応用シンポジウム運営委員会 酵素応用シンポジウム奨励賞
- 2011 - 長瀬財団 Nagase Foundation Award
- 2010 - 日本放線菌学会 日本放線菌学会 学会賞
- 2004 - 住木・梅澤記念賞
- 2004 - Sumiki & Umezawa Award from Japan Antibiotic Research Association
- 2002 - 日本農芸化学会論文賞
- 2000 - 日本農芸化学会奨励賞
- 2000 - Encouragement Award from Japan Society for Bioscience, Biotechnology, and Agrochemistry
- 1999 - とやま賞
- 1999 - TOYAMA Award from Toyama Hitodukuri Foundation
- 1998 - 日本放線菌学会浜田賞
- 1998 - Encouragement Award from The Society for Actinomycetes Japan
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Association Membership(s) (3)：
日本生物工学会
, 日本放線菌学会
, 日本農芸化学会
