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J-GLOBAL ID：200901050726079892 Update date: Jan. 17, 2025

Dairi Tohru

ダイリトオル | Dairi Tohru

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Affiliation and department：
Job title： Professor
Homepage URL (1)： https://www.eng.hokudai.ac.jp/labo/tre/ABCLab_jp/

Research field (2)： Applied microbiology , Bioorganic chemistry

Research keywords (3)：生合成 , 天然物 , Natural product biosynthesis

Research theme for competitive and other funds (29)：

2022 - 2027 Dissecting biosynthetic machineries of natural peptides leading to structural and functional diversities.
2018 - 2022 Dissecting reaction mechanisms of novel peptide epimerases
2016 - 2021 Redesigning Biosynthetic Machineries (Project Team)
2016 - 2021 Studies on biosynthetic machinery of biologically active natural products
2016 - 2021 Redesigning Biosynthetic Machineries (International Activity Support Team)

2015 - 2018 Biosynthesis of the Carbonylmethylene Structure Found in a Class of Pseudotripeptides, Ketomemicins

2010 - 2016 Biosynthetic machinery: Deciphering and regulating the system for creating structural diversity of baioactive metabolites

2013 - 2015 Peptide synthesis cooperatively achieved by peptide ligase and ribosomes

2011 - 2015 Studies on biosynthetic machineries for cyclic terpenoids and nucleoside antibiotics

2012 - 2014 Study on a novel folate biosynthesis pathway on micoorganism

2012 - 2012 Estimation of an alternative biosynthetic pathway for co-factors by close investigation of genome databases.

2010 - 2012 Screening of natural products which inhibits a new menaquinone biosynthetic pathway

2011 - 2011 微生物が生産する環状テルペノイド生合成マシナリーの解明と再構築

2008 - 2009 病原菌が持つメナキノン新規生合成経路の全容解明と経路特異的阻害剤の探索

2007 - 2009 Studies on diterpene cyclases found in eubacteria

2006 - 2007 病原菌が持つメナキノン新規生合成経路の全容解明と経路特異的阻害剤の探索

2005 - 2007 Studies on a new biosynthetic pathway for menaquinone (vitamin K)

2004 - 2006 Studies on production and improvement of terpenoids using biosynthetic gene cluster in fungi and plants.

2004 - 2006 Studies on isoprenoid biosynthetic genes isolated from prokaryotes

2002 - 2003 Studies on diterpene cydases found in actinomycetes.

2001 - 2003 Scientific research on elucidation of terpene-cyclic reactions in the biosynthesis of bioactive microbial terpenoids.

2000 - 2001 Studies on the biosynthesis of terpenoids produced by streptomycetes.

1996 - 1998 Cloning and Analysis of Tautomycin Biosynthetic Genes

1996 - 1997 Reaction Mechanisms and Application of New Bacterial Enzymes

1995 - 1996 Development of Novel Lyases and Their Application to the Synthesis of Optically Active Compounds

1996 - Studies on biosynthesis of terpenoids produced by microorganisms

1994 - Studies on antibiotic biosynthesis

Studies on biosynthesis of natural product

Studies on biosynthetic genes and enzymes of isoprenoids produced by microorganisms

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Papers (150)：

Takeshi Tsunoda, Shunkichi Furumura, Haruka Yamazaki, Chitose Maruyama, Yoshimitsu Hamano, Yasushi Ogasawara, Tohru Dairi. Biosynthesis of lactacystin as a proteasome inhibitor. Communications chemistry. 2025. 8. 1. 9-9
Ning Shen, Yasuharu Satoh, Daisuke Koma, Hiroyuki Ohashi, Yasushi Ogasawara, Tohru Dairi. Optimization of tyrosol-producing pathway with tyrosine decarboxylase and tyramine oxidase in high-tyrosine-producing Escherichia coli. Journal of Bioscience and Bioengineering. 2024. 137. 2. 115-123
Shuhei Umetsu, Takeshi Tsunoda, Haruka Kiyanagi, Yuki Inahashi, Kenichi Nonaka, Tohru Dairi, Yasushi Ogasawara. Identification of a new oligomycin derivative as a specific inhibitor of the alternative peptidoglycan biosynthetic pathway. The Journal of antibiotics. 2024
Hinata Kato, Moeka Sakuta, Takeshi Tsunoda, Yu Nakashima, Hiroyuki Morita, Yasushi Ogasawara, Tohru Dairi. Peptide Epimerase Responsible for d-Amino Acid Introduction in Poly-γ-glutamic Acid Biosynthesis. Biomacromolecules. 2023. 25. 1. 349-354
Yu Nakashima, Atsushi Kawakami, Yasushi Ogasawara, Masatoshi Maeki, Manabu Tokeshi, Tohru Dairi, Hiroyuki Morita. Structure of lasso peptide epimerase MslH reveals metal-dependent acid/base catalytic mechanism. Nature Communications. 2023. 14. 1

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MISC (157)：

尾形海斗, 仲間陸, 小林飛悠, 角田毅, 丸山千登勢, 濱野吉十, 氏原哲朗, 小笠原泰志, 大利徹. Dissecting Ketosynthase Domains in Microalgal Polyunsaturated Fatty Acid Synthase. 日本農芸化学会大会講演要旨集(Web). 2024. 2024
川田智哉, 小林飛悠, 大塚慎, 角田毅, 丸山千登勢, 濱野吉十, 氏原哲朗, 小笠原泰志, 大利徹. Dissecting Dehydratase Domains in Microalgal Polyunsaturated Fatty Acid Synthase. 日本農芸化学会大会講演要旨集(Web). 2024. 2024
高橋佑大, 角田毅, 小笠原泰志, 大利徹. Biosynthetic Study of Antitumor Antibiotic Mitomycins. 日本農芸化学会大会講演要旨集(Web). 2024. 2024
西田壮吾, 成冨駿, 小倉勇輝, 山崎陽香, 角田毅, 勝山陽平, 勝山陽平, 小笠原泰志, 大利徹. Studies on biosynthesis of hydrazide-containing natural product. 日本農芸化学会大会講演要旨集(Web). 2024. 2024
梅澤朱理, 角田毅, 新宅一平, 小笠原泰志, 大利徹. Identification of Novel GTP Cyclohydrolase with Genome Mining. 日本農芸化学会大会講演要旨集(Web). 2024. 2024

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Patents (9)：

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Books (2)：

Isoprenoid Synthesis in Plants and Microorganisms
2013
Comprehensive Natural Products II Chemistry and BiologyMander, L., Lui, H.-W., Eds.volume 1, pp. 789-814.
2010

Education (4)：

- 1985 Nagoya University
- 1985 Nagoya University Graduate School, Division of Agriculture
- 1983 Nagoya University School of Agricultural Sciences
- 1983 Nagoya University Faculty of Agriculture

Professional career (1)：

Agriculture

Work history (5)：

2010/04 - 現在 Hokkaido University Faculty of Engineering
1994/04 - 2010/03 Toyama Prefectural University
1994/04 - 2010/03 - Biotechnology Research Center, Toyama Prefectural University
1985 - 1994 協和発酵工業(株)東京研究所
1985 - 1994 Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.

Committee career (7)：

2017 - 現在日本農芸化学会創立100周年記念事業組織委員会特別委員会委員
2016/04 - 現在バイオインダストリィー協会 B&I 編集幹事
2020/04 - 2024/03 日本放線菌学会学会長
2019/05 - 2021/04 日本生物工学会理事
2019/02 - 2021/02 日本農芸化学会広報委員長

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Awards (18)：

2023/03 - Japan Society for Bioscience, Biotechnology, and Agrochemistry (JSBBA) JSBBA Award Studies on biosynthetic enzymes leading structural and functional diversities to microbial natural products.
2022/03 - 日本農芸化学会トピックス賞微細藻類由来DHA合成酵素の炭素鎖伸長反応の解析
2021/03 - 日本農芸化学会トピックス賞ポリグルタミン酸生合成におけるエピメリ化酵素の同定
2019/03 - 日本農芸化学会トピックス賞 in vitro解析による多価不飽和脂肪酸生合成酵素の炭素鎖長制御機構の解明
2017/03 - 日本農芸化学会トピックス賞 An unprecedented glutamate epimerase for bacterial peptidoglycan biosynthesis

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Association Membership(s) (3)：

日本生物工学会 , 日本放線菌学会 , 日本農芸化学会

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