- 2024 - 2027 Investigation on phase separation-mediated regulation of cell differentiation by droplet transpricptomics
- 2023 - 2027 Development of dropletomics that clarifies transcriptional regulation under liquid-liquid phase separation
- 2024 - 2027 糖代謝障害が招く軟骨肥大性細胞老化を介したO Aの発症機構の解明とC C N2の役割
- 2023 - 2026 Intracellular proteostatic function of CCN2 in chondrocytes during endochondral ossification
- 2022 - 2025 象牙芽細胞の表面に突き出た細胞小器官の機能解析と象牙質再生への応用
- 2022 - 2025 S-アデノシルメチオニンによる軟骨基質産生の新制御機構の解明-ポリアミンを中心に
- 2022 - 2025 非コードRNAを介した新たな軟骨ホメオスタシスとその変性メカニズムの解明
- 2021 - 2025 Regulation of skeletogenesis by long noncoding RNAs through CCN2
- 2020 - 2024 Pioneering chondroneutrigenomics research and its development into chondroneutrigenetics
- 2021 - 2023 Inverse genetics: A new methodology for the identification of key genes of somatic cell differentiation
- 2020 - 2023 CCN2の転写因子様機能を介した線維症のキープレイヤー筋線維芽細胞分化機構の解明
- 2019 - 2023 細胞アンテナによる象牙質再生への道を拓く基礎研究
- 2019 - 2023 CD302の新機能:破骨細胞の分化制御とその機構及び骨・軟骨代謝研究への展開
- 2019 - 2023 Intracellular function and new extracellular signaling pathways of CCN proteins and their common molecular base
- 2018 - 2022 Analysis of mechanism of regulation of CTGF/CCN2 by RUNX2 in tooth formation
- 2018 - 2022 The study of the regulatory mechanisms of cancer bone destruction metabolism and immunity in Hedgehog signaling
- 2019 - 2021 Regulation of CCN2 by an endogenous UTR blocker and its biological significance
- 2017 - 2020 Neutrigenomics studies on endochondral ossification and articular cartilage mainteinance/regeneration
- 2017 - 2020 Mechanism of onset of osteoarthritis caused by obesity and regulatory effects of CCN2
- 2016 - 2020 The investigation of the mechanism of regular arrangement of odontoblasts via extracellular environment sensing sensors
- 2017 - 2019 Novel regulatory mechanism of endochondral ossification via CCN2-VASH1 axis
- 2017 - 2019 New potential of CCN2: Functional evaluation as a Warburg effector
- 2016 - 2019 Roles of CCN2 and Rab14 in the formation of extracellular matrix
- 2015 - 2018 Differential analysis and application at the molecular level of the immunosuppressant action base seen from cartilage tissue
- 2015 - 2018 Analysis of the CTGF/CCN2 expression promotion system which classified cartilage regenerative therapy into the field
- 2015 - 2018 Study on adhesion system for composite CAD/CAM blocks using molecular control technology
- 2015 - 2018 Mechanism and expression of CD302 as a new regulator of osteoclast maturation
- 2015 - 2018 Establishment of molecular basis of CCN family proteins for therapeutic use and its related translational research
- 2014 - 2017 Effect of CCN2 on the osteocyte function regulating the osteoclast formation, and its possibility as a novel drug of osteoporosis
- 2014 - 2017 CCN2個別モジュールの機能解明と変形性関節症治療薬開発に向けた橋渡し研究
- 2013 - 2016 Novel function of CCN3: A regulator of endochondral ossification
- 2013 - 2016 Investigation on the biological diarchy by CCN2 and CCN3 for integrated tissue development
- 2014 - 2016 The presence and its significance of non-canonical action of decoy receptors
- 2013 - 2016 軟骨細胞分化の運命決定と関節防御ーCCN3分子機能の新局面
- 2012 - 2015 Elucidation of molecular basis of CCN family action as masterminds and its medical application
- 2010 - 2014 The technological development of bioengineered regenerated tooth, based on the mechanism of development
- 2011 - 2013 Analysis of molecular mechanism of muscle heterotopic ossification by forming a network with CCN family proteins
- 2011 - 2013 Functional analysis of CCN2 as a metabolic supporter and potential clinical applications in chondrocyte regeneration
- 2011 - 2012 A new protein transport system in cartilage: Multilayered transcytosis
- 2010 - 2011 The analysis of binding of CTGF/CCN2 to RANK and its effects on RANK/RANKL signaling
- 2009 - 2011 Development and medical application of peptide and RNA aptamers that bind to CCN2
- 2009 - 2011 Role of a ubiquitin ligase for Sox9 on endochondral ossification and neurological disorder
- 2007 - 2011 Comprehensive study on molecular basis of actions of CCN family proteins as novel signal conductors and its translational application
- 2008 - 2010 Clarification of molecular mechanism on the osteoclastogenesis promoted by CCN family 2/connective tissue growth factor
- 2007 - 2008 付着歯肉の分化に関連した特異的遺伝子・蛋白の同定とその機能解析
- 2007 - 2008 Regulation of CCN family gene expression via micro RNA regulatory network and its Biological signficance
- 2007 - 2008 Analysis of the role of cartilage-specific gene in endochondral bone formation using BAC (bacterial artificial chromosome)-transgenic mice
- 2007 - 2008 MMPの新機能:マトリクス合成促進因子の転写因子としての役割
- 2005 - 2008 Establishment of Information Basis for Tooth Regeneration
- 2006 - 2007 結合組織成長因子(CCN2/CTGF)を用いた顎顔面領域の三次元軟骨再生
- 2005 - 2006 Role of CCN2 as a trans-modulator in the integrated development of bone, cartilage and hematopoietic systems
- 2003 - 2006 The role of CTGF as a novel tissue-regenerating factor, regenerin, and its application for medical and dental tissue engineering
- 2004 - 2005 RNA干渉を用いたCCN遺伝子ファミリーの包括的機能解析とその応用
- 2004 - 2005 Establishment of an autologous cell transplantion method using mesenchymal stem cells for alveolus bone regeneration.
- 2003 - 2005 Cloning, Expression and Identification of Specific Genes related Osseointegration to Titanium.
- 2003 - 2004 口腔インプラントの骨結合獲得難易度を予測する生物学的診断法の開発
- 2003 - 2004 間葉系幹細胞の遺伝子発現プロファイル解析と硬組織再生への応用
- 2002 - 2004 Establishment of a autologous cell transplantion method using mesenchymal stem cells for perio-dontal tissue and alveolus bone regeneration.
- 2002 - 2004 Study of a key factor in chondrogenic differentiation for craniofacial skeletal regeneration
- 2002 - 2003 Development of the methods for application of the factors that biologically accelerate reparative dentin formation
- 2002 - 2003 Molecular mechanism of temporomandibular joint osteoarthritis and gene therapy for degraded, cartilage
- 2002 - 2003 Functional dissection and medical application of the 4 modules in the chondrocyte-derived growth factor, ecogenin/CTGF.
- 2001 - 2002 軟骨成長因子エコジェニン/CTGFによる生体デザインを目指す研究
- 2001 - 2002 Investigation of mechanism of connective tissue growth factor (CTGF) as a molecular target against cancer-induced bone destruction
- 2001 - 2002 MMP-3転写調節部位遺伝子多型からみた顎関節症の予後に関する分子遺伝学的研究
- 2001 - 2002 Functional analysis of the cartilage-derived multifunctional growth factor ecogenin/CTGF by using mutant animals
- 2000 - 2002 Gene therapy for temporomandibular joint osteoarthritis
- 2000 - 2001 Investigation of the intracellular function of human ecogenin/CTGF, a chondrocyte-derived growth factor.
- 2000 - 2001 Analysis of gene expression in chondrocytes using DNA microarrays (DNA chips)
- 2000 - 2001 Development of analytical method for each domain of CTGF/ecogenin and its clinical application.
- 2000 - 2001 Ex Vivo Gene Delivery Using an Adenovirus Vector in Treatment for Dental Implant
- 2000 - 2001 Molecular cloning of the factors that biologically accelerate reparative dentin formation
- 1999 - 2001 アデノウイルスベクター法を用いた早期osseointegrationの獲得
- 1999 - 2001 Investigation of the regulatory mechanism of gene expression of human ecogenin/CTGF, a chondrocyte-derived growth factor.
- 1999 - 2000 軟骨由来成長因子エコジェニン/CTGFを用いた歯周組織再建への試み
- 1998 - 2000 Studies on the mechanism of actions of a cartilage-derived pleiotrophic growth factor, ecogenin/CTGF - Molecular cloning of its receptors and mechanism of inter- and intra signal transduction -
- 1998 - 1999 Development of inhibitors for a angiogenesis factor CTGF and its application for angiogenetic diseases
- 1998 - 1999 The cloning and application of growth factors in restorative dentine
- 1998 - 1999 Effect of mechanical stress on chondrocytes metabolism
- 1997 - 1999 Molecular cloning of the receptors for chondrosarcoma-derived chondrocyte growth factor Ecogenin/CTGF
- 1997 - 1999 INVESTIGATION OF MECHANISM OF BONE METTASTASIS AND MOLECULAR CLONING OF BONE METASITASIS RELATED GENE
- 1997 - 1998 アデノウイルスベクターを用いた遺伝子導入法による顎関節症の遺伝子治療の試み
- 1997 - 1998 Basic Research of Gene Therapy for Joint Diseases
- 1996 - 1997 Regulation of IGF-2 gene expression in human chondrosarcoma derived cell lines : HCS-2/8 and -2/A
- 1996 - 1997 Molecular cloning of novel osteoneurotrophins and their application as therapeutic agents for bone and cartilage diseases
- 1996 - 1997 The role of hcs-24, a newly isolated hypertrophic chondrocyte-specific gene, in endochondral ossification
- 1994 - 1995 Expression and promoter-alternation of osteoblastic insulin-like growth factors
- 1994 - 1995 Cloning and functional analysis of novel genes related to chondrocyte differentiation using the human chondrocytic cell lines
- 1991 - 1992 Studies on the mechanism of endochondral ossification using a clonal chondrocyte like cell line newly established from a human chondrosarcoma - approach using the methods of cellular and molecular biology
- 1989 - 1990 Purification of Receptors to Parathyroid Hormone from Cultured Chondrocytes and the Mechanism of its Signal Transduction
- 1988 - 1989 Studies on mechanisms of proliferation, differentiation and calcification of chondrocytes using established clonal cell lines.
- 1986 - 1987 Purification of cartilage-derived anti-tumor factor (CATF) and establishment of cell lines which produce CATF
- 1985 - 1987 Bioassays for parathyrois hormone using clutures chondrocytes
- 1986 - 1986 軟骨細胞の増殖・分化と骨形成におけるビタミンDの作用機作
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- 2021/04 - 現在 岡山大学 学術研究院医歯薬学域 歯学部先端領域研究センター 教授(副センター長)
- 2014 - 現在 Okayama University
- 2019/04 - 2021/03 Okayama University Graduate School of Medicine , Dentistry and Pharmaceutical Sciences
- 2014 - 2019 Okayama University Graduate School of Medicine , Dentistry and Pharmaceutical Sciences
- 2011 - 2017 日本学術会議連携会員
- 2005 - 2014 Okayama University Graduate School of Medicine , Dentistry and Pharmaceutical Sciences
- 2006 - 2008 Okayama University
- 2001 - 2005 Okayama University
- 1994 - 2005 Professor,School of Dentistry,Dental School,Okayama University
- 2005 - - Professor,School of Dentistry,Dental School,Okayama University
- 2005 - - Professor,Science of Functional Recovery and Reconstruction,Graduate School of Medicine, Dentistry and Pharmaceutical Sciences,Okayama University
- 2000 - 2002 Okayama University
- 1994 - 2001 Okayama University Dental School
- 1991 - 1994 Osaka University School of Dentistry
- 1991 - 1994 Associate Professor, Osaka University Dental School
- 1981 - 1991 Osaka University School of Dentistry
- 1981 - 1991 Senior Assistant Professor,1981-1991 Assitant Professor, Osaka University Dental School
- 1980 - 1982 米国ウイスコンシン大学 マッカードル癌研究所 博士研究員
- 1980 - 1982 Researcher,University of Wisconsin
- 1977 - 1981 Osaka University School of Dentistry
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日本軟骨代謝学会
, 日本癌学会
, 日本骨代謝学会
, American Society for Biochemistry and Molecular Biology
, International CCN Society
, 歯科基礎医学会
, 日本再生医療学会
, 岡山歯学会
, 大阪大学歯学会
, 日本血管細胞生物学会
, 日本リウマチ学会
, 日本結合組織学会
, 日本分子生物学会
, 日本生化学会
, American Association for Cancer Research
, American Association for the Advancement of Science
, International Bone and Mineral Society
, American Society for Bone and Mineral Research