Kubohara Yuzuru

クボハラユズル | Kubohara Yuzuru

Affiliation and department：
Other affiliations (1)：

Research field (4)： Pharmacology , Pharmaceuticals - health and biochemistry , Developmental biology , Cell biology

Research keywords (10)：創薬 , 抗腫瘍剤 , 生物化学 , 発生生物学 , 細胞生物学 , Drug development , Anti-tumor agent , Biochemistry , Developmental Biology , Cell Biology

Research theme for competitive and other funds (32)：

2022 - 2025 免疫系培養細胞を用いたセクリトーム解析による新規生物活性物質の網羅的探索
2019 - 2023 運動がアレルギー疾患を抑制する機序の解明
2019 - 2022 細胞性粘菌由来の生物活性物質をシードとした創薬〜新規抗がん剤と抗菌薬の開発
2020 - 2021 Development of novel anti-obesity and -diabetic drugs and analysis of the mecha-nism(s) underlying the actions of the drugs
2019 - 2020 新規肥満・糖尿病治療薬の開発とその作用機序解析

Show all

Papers (94)：

Takehiro Nishimura, Takuya Murotani, Hitomi Sasaki, Yoshinori Uekusa, Hiromi Eguchi, Hirotaka Ishigaki, Katsunori Takahashi, Yuzuru Kubohara, Haruhisa Kikuchi. Isolation and Structure Determination of New Pyrones from Dictyostelium spp. Cellular Slime Molds Coincubated with Pseudomonas spp. Molecules. 2024. 29. 9. 2143-2143
Naoko Yoshida, Haruhisa Kikuchi, Makoto Hirai, Betty Balikagala, Denis A Anywar, Hikari Taka, Naoko Kaga, Yoshiki Miura, Naoyuki Fukuda, Emmanuel I Odongo-Aginya, et al. A longer-chain acylated derivative of Dictyostelium differentiation-inducing factor-1 enhances the antimalarial activity against Plasmodium parasites. Biochemical pharmacology. 2024. 225. 116243-116243
Yuzuru Kubohara, Yuko Fukunaga, Ayako Shigenaga, Haruhisa Kikuchi. Dictyostelium Differentiation-Inducing Factor 1 Promotes Glucose Uptake via Direct Inhibition of Mitochondrial Malate Dehydrogenase in Mouse 3T3-L1 Cells. International Journal of Molecular Sciences. 2024. 25. 3. 1889-1889
Yuzuru Kubohara, Yuko Fukunaga, Haruhisa Kikuchi, Hidekazu Kuwayama. Pharmacological Evidence That Dictyostelium Differentiation-Inducing Factor 1 Promotes Glucose Uptake Partly via an Increase in Intracellular cAMP Content in Mouse 3T3-L1 Cells. Molecules. 2023. 28. 23. 7926-7926
Hidekazu Kuwayama, Haruhisa Kikuchi, Yuzuru Kubohara. Derivatives of Differentiation-Inducing Factor 1 Differentially Control Chemotaxis and Stalk Cell Differentiation in Dictyostelium discoideum. Biology. 2023. 12. 6. 873-873

ｍore...

MISC (18)：

石垣宏尚, 高橋克典, 久保原禅, 菊地晴久, 藤田清貴. 合成化合物を対象とした新規免疫制御剤の探索. 臨床化学. 2018. 47. Supple.1. 312-312
佐々木啓, 山本菜々子, 鈴木良雄, 飯泉恭一, 久保原禅. 生物活性物質DIF誘導体を用いたヒスタミン生成抑制技術の開発. 順天堂スポーツ健康科学研究. 2018. 9. Supple. 6-6
NAKAZATO Ryunosuke, IIZUMI Kyoichi, SASAKI Hiraku, SHIGENAGA Ayako, OGATA Makoto, AOKI Daichi, MISAWA Yoshinori, HOSOMI Osamu, KUBOHARA Yuzuru. Effects of a novel oligosaccharide, MelNH2, on human breast cancer cells. J. Health & Sports Science Juntendo. 2018. 9. 1. 1-10
KUBOHARA Yuzuru, KIKUCHI Haruhisa, OSHIMA Yoshiteru. Derivatives of Dictyostelium differentiation-inducing factors inhibit serum-dependent cell migration of murine osteosarcoma LM8 cells. Juntendo Medical Journal. 2018
佐々木啓, 馬場猛, 細見修, 久保原禅. 食物アレルギーの持続的抑制技術の開発. 順天堂スポーツ健康科学研究. 2016. 7. Suppl. 3-3

ｍore...

Patents (9)：

ｍore...

Books (6)：

ｍore...

Lectures and oral presentations (107)：

DIF-1による糖代謝促進作用とAMP kinase
(日本細胞性粘菌学会第10回例会 2020)
DIF誘導体の有する抗菌活性
(日本細胞性粘菌学会第9回例会 2019)
ハロゲン置換した DIF 誘導体の抗腫瘍作用
(日本細胞性粘菌学会第9回例会 2019)
粘菌は未利用創薬資源!?
(上智大学コロキウム 2018)
DIF-1とその誘導体が有する抗菌活性の研究
(日本細胞性粘菌学会第7回例会 2017)

ｍore...

Education (2)：

Professional career (2)：

Work history (4)：

2015/04 - 現在 Juntendo University Graduate School of Health & Sports Science Professor
1993/10 - 2015/03 Institute for Molecular and Cellular Regulation, Gunma University Assistant Professor/Associate Professor
1993/04 - 1993/09 Faculty of Integrated Human Studies, Kyoto University Lecturer (part-time)
1991/04 - 1993/03 日本学術振興会特別研究員

Committee career (2)：

Association Membership(s) (6)：

日本公衆衛生学会 , 日本発生生物学会 , 日本生化学会 , 日本細胞生物学会 , 日本細胞性粘菌学会 , International Dictyostelium Society

※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

Return to Previous Page